Chronic Microelectrode Investigations of Normal Human Brain Physiology Using a Hybrid Depth Electrode

Howard, Matthew A.; Volkov, I. O.; Noh, Myounggyu; Granner, Mark A.; Mirsky, Roman; Garell, P. Charles

doi:10.1159/000099931

Cited by 11 publications

(8 citation statements)

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“…Beside the costs, some centers are cautious about microelectrode recordings as it has been discussed whether the use of many small microwires instead of one macroelectrode may induce additional neuronal damage during the implantation. So far however these concerns were not confirmed (Howard et al, 1997; Ulbert et al, 2001). …”

Section: Clinical Aspects Of Hfos In Epilepsymentioning

confidence: 94%

High-frequency oscillations (HFOs) in clinical epilepsy

Jacobs

Staba

Asano

et al. 2012

Progress in Neurobiology

374

349

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Section: Clinical Aspects Of Hfos In Epilepsymentioning

confidence: 94%

High-frequency oscillations (HFOs) in clinical epilepsy

Jacobs

Staba

Asano

et al. 2012

Progress in Neurobiology

374

349

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“…The hidden supratemporal plane can be visualized on the surface that results from an oblique horizontal sectioning, perpendicular to the lateral hemisphere ( Fig 1B ). Chronically implanted electrodes in human subjects [ 5 ] have been used to identify a portion of Heschl’s gyrus ( Fig 1B and 1C ) on the supratemporal plane that is consistent with it being the primary and primary-like (core) auditory cortex [ 6 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Sparse Spectro-Temporal Receptive Fields Based on Multi-Unit and High-Gamma Responses in Human Auditory Cortex

et al. 2015

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Spectro-Temporal Receptive Fields (STRFs) were estimated from both multi-unit sorted clusters and high-gamma power responses in human auditory cortex. Intracranial electrophysiological recordings were used to measure responses to a random chord sequence of Gammatone stimuli. Traditional methods for estimating STRFs from single-unit recordings, such as spike-triggered-averages, tend to be noisy and are less robust to other response signals such as local field potentials. We present an extension to recently advanced methods for estimating STRFs from generalized linear models (GLM). A new variant of regression using regularization that penalizes non-zero coefficients is described, which results in a sparse solution. The frequency-time structure of the STRF tends toward grouping in different areas of frequency-time and we demonstrate that group sparsity-inducing penalties applied to GLM estimates of STRFs reduces the background noise while preserving the complex internal structure. The contribution of local spiking activity to the high-gamma power signal was factored out of the STRF using the GLM method, and this contribution was significant in 85 percent of the cases. Although the GLM methods have been used to estimate STRFs in animals, this study examines the detailed structure directly from auditory cortex in the awake human brain. We used this approach to identify an abrupt change in the best frequency of estimated STRFs along posteromedial-to-anterolateral recording locations along the long axis of Heschl’s gyrus. This change correlates well with a proposed transition from core to non-core auditory fields previously identified using the temporal response properties of Heschl’s gyrus recordings elicited by click-train stimuli.

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“…The hybrid nature of the microelectrode and macroelectrode recording allowed detection of multiunit neuronal activity. Detection of multiunit activity on the high impedance microcontacts throughout the recording period suggests viable cortex within ~ 100 μm of the electrode shaft 4,5…”

Section: Resultsmentioning

confidence: 99%

A method for placing Heschl gyrus depth electrodes

Reddy

Dahdaleh

Albert

et al. 2010

JNS

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A wide range of devices is used to obtain intracranial electrocorticography recordings in patients with medically refractory epilepsy, including subdural strip and grid electrodes and depth electrodes. Penetrating depth electrodes are required to access some brain regions, and 1 target site that presents a particular technical challenge is the first transverse temporal gyrus, or Heschl gyrus (HG). The HG is located within the supratemporal plane and has an oblique orientation relative to the sagittal and coronal planes. Large and small branches of the middle cerebral artery abut the pial surface of the HG and must be avoided when planning the electrode trajectory. Auditory cortex is located within the HG, and there are functional connections between this dorsal temporal lobe region and medial sites commonly implicated in the pathophysiology of temporal lobe epilepsy. At some surgical centers, depth electrodes are routinely placed within the supratemporal plane, and the HG, in patients who require intracranial electrocorticography monitoring for presumed temporal lobe epilepsy. Information from these recordings is reported to facilitate the identification of seizure patterns in patients with or without auditory auras. To date, only one implantation method has been reported to be safe and effective for placing HG electrodes in a large series of patients undergoing epilepsy surgery. This well-established approach involves inserting the electrodes from a lateral trajectory while using stereoscopic stereotactic angiography to avoid vascular injury. In this report, the authors describe an alternative method for implantation. They use frameless stereotaxy and an oblique insertion trajectory that does not require angiography and allows for the simultaneous placement of subdural grid arrays. Results in 19 patients demonstrate the safety and efficacy of the method.

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Chronic Microelectrode Investigations of Normal Human Brain Physiology Using a Hybrid Depth Electrode

Cited by 11 publications

References 0 publications

High-frequency oscillations (HFOs) in clinical epilepsy

High-frequency oscillations (HFOs) in clinical epilepsy

Sparse Spectro-Temporal Receptive Fields Based on Multi-Unit and High-Gamma Responses in Human Auditory Cortex

A method for placing Heschl gyrus depth electrodes

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