Chronic Medical Illness in Patients With Recurrent Major Depression

Miller, Mark D.; Paradis, Cynthia F.; Houck, Patricia R.; Rifai, A. Hind; Mazumdar, Sati; Pollock, Bruce G.; Perel, James M.; Frank, Ellen; Reynolds, Charles F.

doi:10.1097/00019442-199600440-00002

Cited by 18 publications

(15 citation statements)

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“…However, consistent with our hypothesis, subthreshold symptoms of depressed mood predicted longitudinal progression of white matter disease in older men but not women. Numerous studies have shown that individuals with vascular disease are at an increased risk of developing depression (Katz et al, 1994;Lyness et al, 1996;Miller et al, 1996;Kumar et al, 1997;Krishnan et al, 2002;Tiemeier et al, 2004). Longitudinal neuroimaging studies have shown that WMHs are associated with response to treatment, chronicity of symptoms, cognitive deficits, and functional outcomes in depressed older adults (Hickie et al, 1997;O'Brien et al, 1998;Lavretsky et al, 1999;Steffens et al, 2002;Taylor et al, 2003b;Kales et al, 2005;Steffens et al, 2007;Teodorczuk et al, 2007;Teodorczuk et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…A relationship between late-life depression and vascular disease has been widely reported (Musselman et al, 1998;Thomas et al, 2004;Kales et al, 2005). Patients with vascular diseases such as hypertension, diabetes, and coronary artery disease have disproportionately higher rates of depression compared to the general population and individuals with other medical conditions (Katz et al, 1994;Lyness et al, 1996;Miller et al, 1996;Kumar et al, 1997;Krishnan et al, 2002;Tiemeier et al, 2004). High rates of depression following a stroke (Folstein et al, 1977;Burvill et al, 1995;Pohjasvaara et al, 1998;Angelelli et al, 2004;Whyte et al, 2004) and coronary artery bypass grafting (Reichenberg et al, 2007) also suggest a link between vascular disease and depression.…”

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confidence: 99%

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Temporal relationships between depressive symptoms and white matter hyperintensities in older men and women

Dotson

Zonderman

Kraut

et al. 2012

Int J Geriat Psychiatry

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Objective Associations between vascular disease and depression in late life, including increased white matter hyperintensities (WMHs), have been reported. Whether depression is an etiology or a consequence of vascular disease is still unknown. We investigated the temporal relationship between depressive symptoms and WMHs in older men and women. Methods We utilized data from 90 dementia-free older adults (39 women, 51 men), 57 years of age and older at baseline, from the neuroimaging substudy of the Baltimore Longitudinal Study of Aging. Participants were followed for up to 8 years. Ratings of white matter disease burden were available for the first, last, and at least one interim visit, and participants completed the Center for Epidemiologic Studies Depression Scale (CES-D) annually. Statistical models, performed separately in men and women, examined whether depressive symptoms predicted subsequent WMH ratings or WMHs predicted subsequent depressive symptoms. Results The total CES-D score was not associated with WMHs in men or women. In men, the CES-D depressed mood subscale predicted accelerating longitudinal increases in WMHs at older ages, but WMHs did not predict subsequent depressive symptoms. In women, there were no significant associations between the CES-D depressed mood subscale and WMHs. Conclusions White matter disease may be a consequence of depressed mood in men but not in women. Intervention strategies for depression may slow the progression of white matter disease in older men. These results add to previous findings documenting sex differences in the correlates of depressive disorders in late life.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Temporal relationships between depressive symptoms and white matter hyperintensities in older men and women

Dotson

Zonderman

Kraut

et al. 2012

Int J Geriat Psychiatry

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“…Until now, the number of studies investigating depression as a potential risk factor for developing somatic disease, however, is limited. The association between depression and chronic illness in general (6–8), as well as the relation between depression and diabetes mellitus (DM) have been described before (9). The underlying mechanism for this association is, however, less clear.…”

Section: Introductionmentioning

confidence: 99%

“…Most studies have evaluated the cross‐sectional relationship between depression and DM (6, 13, 14), the presence of depression in diabetics (9, 15–18), or the presence of DM in depressed subjects without comparing it with a control group (8, 19). A meta‐analysis by Anderson et al.…”

Section: Introductionmentioning

confidence: 99%

Is depression related to subsequent diabetes mellitus?

Akker

Schuurman

Metsemakers

et al. 2004

Acta Psychiatr Scand

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“…Following the success of early trials, IPT has been helpful for diverse and low-income patient populations (Brown, Schulberg, Sacco, Perel, & Houck, 1999; Rossello & Bernal, 1999; Spinelli & Endicott, 2003) and in a variety of clinical contexts, including medical settings (Grote, Bledsoe, Swartz, & Frank, 2004; Schulberg, et al, 1996; Zlotnick, Johnson, Miller, Pearlstein, & Howard, 2001). More recent studies have demonstrated that IPT is effective in treating depression among patients with chronic illnesses, including pain (Karp, et al, 2005), coronary disease (Koszychi, Lafontaine, Frasure-Smith, Swenson, & Lesperance, 2004), HIV+ (Markowitz, et al, 1998), and medically frail older adults (Miller, et al, 1996). IPT has generally required minimal adaptation to fit the needs of different patient populations, and has demonstrated good adherence and treatment satisfaction (Grote, et al, 2004; Koszychi, et al, 2004; Swartz, et al, 2004; Zlotnick, et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Interpersonal psychotherapy for co-occurring depression and chronic pain.

Poleshuck

Gamble

Cort

et al. 2010

Professional Psychology: Research and Practice

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Up to 37% of individuals experience chronic pain during their lifetimes. Approximately onefourth of primary care patients with chronic pain also meet criteria for major depression. Many of these individuals fail to receive psychotherapy or other treatment for their depression; moreover when they do, physical pain is often not addressed directly. Women, socioeconomically disadvantaged individuals, African Americans and Latinos all report higher rates of pain and depression compared to other groups. This article describes a version of Interpersonal Psychotherapy tailored for patients with comorbid depression and chronic pain, Interpersonal Psychotherapy for Depression and Pain (IPT-P). While IPT-P potentially could be delivered to many different patient populations in a range of clinical settings, this article focuses on its delivery within primary care settings for socioeconomically disadvantaged women. Adaptations include a brief 8-session protocol that incorporates strategies for anticipating barriers to psychotherapy, accepting patients' conceptualization of their difficulties, encouraging patients to consider the impact of their pain on their roles and relationships, emphasizing self-care, incorporating pain management techniques, and flexible scheduling. In addition, IPT-P is designed as an adjunct to usual medical pain treatment, and seeks to engage non-treatment seeking patients in psychotherapy by focusing on accessibility and relevance of the intervention to concerns common among patients with pain. Identifying patients with comorbid depression and chronic pain and offering IPT-P as a treatment option has the potential to improve clinical outcomes for individuals with depression and chronic pain.

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Chronic Medical Illness in Patients With Recurrent Major Depression

Cited by 18 publications

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Temporal relationships between depressive symptoms and white matter hyperintensities in older men and women

Temporal relationships between depressive symptoms and white matter hyperintensities in older men and women

Is depression related to subsequent diabetes mellitus?

Interpersonal psychotherapy for co-occurring depression and chronic pain.

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