Chronic medical conditions and reproducibility of self-reported age at menopause among community-dwelling women

Vries, Heather F. de; Northington, Gina M.; Kaye, Elise M.; Bogner, Hillary R.

doi:10.1097/gme.0b013e31821f92f2

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…During the perimenopausal period, the menstrual cycle duration becomes more inconsistent and women may skip periods 16 . Hence, it is quite likely that women find it increasingly hard to recall the time of their last menses accurately with length of time since menopause occurred: inconsistencies between reported menopausal age from repeated interviews supports this 17‐19 . Misreporting and missing values for age at menopause or menarche are unlikely to be random events and are more likely in case–control studies of aging‐related outcomes as this information is often collected many years after the menopausal transition occurred.…”

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confidence: 99%

Increased Menopausal Age Reduces the Risk of Parkinson's Disease: A Mendelian Randomization Approach

et al. 2021

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A BS TRACT: Background: Studies of Parkinson's disease (PD) and the association with age at menarche or menopause have reported inconsistent findings. Mendelian randomization (MR) may address measurement errors because of difficulties accurately reporting the age these life events occur. Objective: We used MR to assess the association between age at menopause and age at menarche with PD risk. Methods: We performed inverse variant-weighted (IVW) MR analysis using external genome-wide association study (GWAS) summary data from the United Kingdom biobank, and the effect estimates between genetic variants and PD among two population-based studies (Parkinson's disease in Denmark (PASIDA) study, Denmark, and Parkinson's Environment and Gene study [PEG], United States) that enrolled 1737 female and 2430 male subjects of European ancestry. We, then, replicated our findings for age at menopause using summary statistics from the PD consortium (19 773 women), followed by a meta-analysis combining all summary statistics.Results: For each year increase in age at menopause, the risk for PD decreased (odds ration [OR], 0.84; 95% confidence interval [CI], 0.73-0.98; P = 0.03) among women in our study, whereas there was no association among men (OR, 0.98; 95% CI, 0.85-1.11; P = 0.71). A replication using summary statistics from the PD consortium estimated an OR of 0.94 (95% CI, 0.90-0.99; P = 0.01), and we calculated a meta-analytic OR of 0.93 (95% CI, 0.89-0.98; P = 0.003). There was no indication for an association between age at menarche and PD (OR, 0.75; 95% CI, 0.44-1.29; P = 0.29). Conclusions: A later age at menopause was associated with a decreased risk of PD in women, supporting the hypothesis that sex hormones or other factors related to late menopause may be neuroprotective in PD.

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confidence: 99%

Increased Menopausal Age Reduces the Risk of Parkinson's Disease: A Mendelian Randomization Approach

et al. 2021

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“…Demographic and clinical information including age, menstrual status, and gravidity were documented for each patient. Perimenopausal status was defined as age 48-51 and post-menopausal status was defined as ages 53 and above [13,14].…”

Section: Methodsmentioning

confidence: 99%

Ovarian Torsion: Time Limiting Factors for Ovarian Salvage

Gh¹,

ehari²,

Kahn³

et al. 2015

Emerg Med (Los Angel)

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Aim: Analysis of the timelines in the diagnosis and management of surgically treated ovarian torsion will provide novel information on significant time intervals that may be amenable to future improvement which will optimize ovarian salvage rates. Methods: A retrospective review was performed of all patients who had surgically confirmed adnexal torsion over 12 years. The following four times were extracted for each patient (1) Emergency Department (ED) Triage (2) ED physician assessment (3) Generation of ultrasound report (4) Operating room (OR) start time. Overall time from ED triage to surgery and ovarian salvage rates were also documented. Results: Of 86 surgically proven ovarian torsion cases, 63 (73%) had documentation of all timelines and were included in the study. The overall median time from ED triage to surgery was 14.8 hours. Individual median times were as follows: from ED triage to ED physician assessment 1.3 hours; ED physician assessment to ultrasound imaging report provision 3 hours and imaging report provision to surgical intervention 6.8 hours. Overall ovarian salvage with detorsion occurred in 34 (54%) of cases. Lengthier time delays to surgery were associated with lower ovarian salvage rates. Conclusion: This study is the first to quantify the time contribution of four major steps in a patient's journey from ED triage to surgical intervention thus providing an opportunity to identify potential targets for quality improvements and serve as a baseline for measuring future improvements. The study confirms that lengthier time delays to surgery are associated with lower ovarian salvage rates.

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“…The questionnaire included questions that asked, after menopause, “Have you ever taken estrogen pills for any reason?” and “How long did you take estrogen pills?” Duration of estrogen use in 1993 was characterized into 3 broad categories (never use, estrogen use < 5 years, estrogen use ≥ 5 years) consistent with Hendrix et al 5 Additional information in 1993 was obtained by standard questions about parity, menopausal duration, and type of menopause (surgical versus nonsurgical). 15 …”

Section: Methodsmentioning

confidence: 99%

Self-reported estrogen use and newly incident urinary incontinence among postmenopausal community-dwelling women

Northington

Vries²,

Bogner³

2012

Menopause

Self Cite

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OBJECTIVE To examine the relationship between self-reported estrogen use and newly-incident urinary incontinence (UI) among community-dwelling postmenopausal women. METHOD A population based longitudinal survey of postmenopausal women who did not report UI in 1993 and for whom complete data were available. Women were classified as having newly-incident UI if they reported uncontrolled urine loss within 12 months of the 2004 interview. Condition-specific functional loss secondary to UI was assessed by questions on participants’ inability to engage in certain activities due to UI. Duration of hormone therapy containing estrogen was obtained in 1993 using a structured questionnaire. RESULTS Among 167 postmenopausal women who did not report UI in 1993, 47 (28.1%) reported newly-incident UI and 31 (18.6%) reported newly-incident UI with condition-specific functional loss in 2004. Of the 167 postmenopausal women, 46 (27.5%) reported ever using hormone therapy containing estrogen and 14 (8.3%) women reported using hormone therapy containing estrogen for 5 years or more in 1993. Estrogen use for 5 years or more was significantly associated with newly-incident UI with condition-specific functional loss compared to estrogen use for less than 5 years or no reported history of estrogen (adjusted relative odds (RO) = 3.97, 95% confidence interval (CI) [1.02, 15.43]) in multivariate models controlling for potentially influential characteristics. CONCLUSIONS Postmenopausal community-dwelling women with a history of estrogen use for 5 years or more were more likely to report newly-incident UI with condition-specific functional loss after 10 years of follow-up.

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Chronic medical conditions and reproducibility of self-reported age at menopause among community-dwelling women

Cited by 4 publications

References 26 publications

Increased Menopausal Age Reduces the Risk of Parkinson's Disease: A Mendelian Randomization Approach

Increased Menopausal Age Reduces the Risk of Parkinson's Disease: A Mendelian Randomization Approach

Ovarian Torsion: Time Limiting Factors for Ovarian Salvage

Self-reported estrogen use and newly incident urinary incontinence among postmenopausal community-dwelling women

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