Chronic Marginal Iron Intakes during Early Development in Mice Result in Persistent Changes in Dopamine Metabolism and Myelin Composition

Kwik‐Uribe, Catherine; Gietzen, Dorothy W.; German, J. Bruce; Golub, Mari S.; Keen, Carl L.

doi:10.1093/jn/130.11.2821

Cited by 146 publications

(94 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Disruptions in iron processing, storage, or availability affect myelin quantity, quality, composition, and compaction (43,44), with alterations that persist even if the iron content of the myelin achieves normal levels after iron supplementation (45). As suggested previously in the same sample (4), the slower transmission in both auditory and visual systems likely arises from iron's role in myelination.…”

Section: Discussionmentioning

confidence: 67%

Iron Deficiency Anemia in Infancy Is Associated with Altered Temporal Organization of Sleep States in Childhood

et al. 2007

View full text Add to dashboard Cite

ABSTRACT:The highest prevalence of iron deficiency anemia (IDA) in infancy coincides with a time of rapid changes in sleep organization. Since IDA in infancy is associated with long-lasting neurofunctional effects despite iron treatment, the normal development of sleep patterns might be affected. Night polysomnographic recordings were performed in 55 healthy 4-y-old children (former IDA ϭ 27, nonanemic controls ϭ 28). Both groups were followed from infancy and were similar in background characteristics. The duration of each waking episode was measured, as was the duration of each episode of nonrapid eye movement (NREM) sleep stages 1 (NREM1), 2 (NREM2), and 3-4 (SWS), and rapid eye movement (REM) sleep. The data were analyzed according to the successive thirds of the total sleep time (TST). Relative to controls, former IDA children showed: a) longer duration of REM sleep episodes in the first third and shorter in the last third; b) more REM sleep episodes in the first third and fewer in the second third; and c) shorter latency to the first REM sleep episode and shorter NREM stage 2 and SWS episodes within the first sleep cycle. The results show that early IDA is associated with long-lasting alterations in the temporal organization of sleep patterns. T his study considered the long-lasting impact of iron deficiency anemia (IDA) in infancy on the organization of sleep states. Iron deficiency-the most common preventable nutritional deficiency in the world and a major cause of anemia-is associated with alterations in development and behavior, particularly during infancy and toddlerhood when there is rapid growth and high need for iron (1,2). We previously reported that infants with IDA showed alterations in sensory pathway functioning and motor activity patterns, with some differences persisting despite timely correction of anemia with carefully supervised iron therapy (3-6). Other studies find poorer mental, motor, and social-emotional functioning in IDA infants, again with differences observed years after iron treatment (2,7). Additionally, animal studies show that rodents that experience early iron deficiency also have persisting behavioral differences related to motor function, learning and memory, and emotional responses (2,8,9).The quality and quantity of sleep are increasingly recognized as important factors in human development, with concomitant effects on affective behavior and cognitive performance (10,11). The organization of sleep depends on various mechanisms involving both neural and humoral processes, several of which are affected by iron deficiency. In rodent models, early iron deficiency impairs several neurotransmitter systems, myelin formation and maintenance, and metabolic neuronal activity (8,12). When iron deficiency occurs during central nervous system (CNS) development in infancy, changes in several functions are not completely reversed with iron therapy at weaning (2,8,9,12).Because iron deficiency in human infants is most prevalent during the latter part of the brain growth spurt, the norma...

show abstract

Section: Discussionmentioning

confidence: 67%

Iron Deficiency Anemia in Infancy Is Associated with Altered Temporal Organization of Sleep States in Childhood

et al. 2007

View full text Add to dashboard Cite

show abstract

“…The cytokine-mediated effects on glucocorticoid secretion may be of special interest because it has been suggested that prenatal physiological stress triggered by high glucocorticoid levels can interfere with normal physiological and metabolic development (130,156). Activation of the innate immune system (in response to infection) also changes the maternal and fetal availability of several micronutrients, including iron and zinc, both of which are highly important for the normal development of peripheral and central organs (3,71,72,149). In the case of iron, it is well established that infection leads to a temporary depletion of iron in the infected host.…”

Section: Possible Mechanisms Mediating the Effects Of Maternal Infectmentioning

confidence: 99%

Long-term pathological consequences of prenatal infection: beyond brain disorders

Labouesse

Langhans

Meyer

2015

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…Myelin was isolated according to Kwik-Uribe et al (2000), and the lipid content was further analyzed as described for cerebrum.…”

Section: Isolation Of Myelinmentioning

confidence: 99%

Absence of Functional Peroxisomes from Mouse CNS Causes Dysmyelination and Axon Degeneration

Hulshagen¹,

Krysko²,

Bottelbergs³

et al. 2008

J. Neurosci.

100

110

View full text Add to dashboard Cite

Peroxisomal metabolism is essential for normal brain development both in men and in mice. Using conditional knock-out mice, we recently showed that peroxisome deficiency in liver has a severe and persistent impact on the formation of cortex and cerebellum, whereas absence of functional peroxisomes from the CNS only causes developmental delays without obvious alteration of brain architecture.We now report that a substantial fraction of the latter Nes-Pex5 knock-out mice survive into adulthood but develop progressive motoric and coordination problems, impaired exploration, and a deficit in cognition and die before the age of 6 months. Histopathologically, both the white and gray matter of the CNS displayed a region-specific accumulation of neutral lipids, astrogliosis and microgliosis, upregulation of catalase, and scattered cell death. Nes-Pex5 knock-out mice featured a dramatic reduction of myelin staining in corpus callosum, whereas cerebellum and other white matter tracts were less affected or unchanged. This was accompanied by a depletion of alkenylphospholipids in myelin and differentially reduced immunoreactivity of myelin proteins. EM analysis revealed that myelin wrappings around axons did still form, but they showed a reduction in thickness relative to axon diameters. Remarkably, multifocal axonal damage occurred in the corpus callosum. Thereby, debris accumulated between axolemma and inner myelin surface and axons collapsed, although myelin sheaths remained present. These anomalies of myelinated axons were already present in juvenile mice but aggravated in adulthood. Together, loss of CNS peroxisomal metabolism both affects myelin sheaths and axonal integrity possibly via independent pathways.

show abstract

Chronic Marginal Iron Intakes during Early Development in Mice Result in Persistent Changes in Dopamine Metabolism and Myelin Composition

Cited by 146 publications

References 63 publications

Iron Deficiency Anemia in Infancy Is Associated with Altered Temporal Organization of Sleep States in Childhood

Iron Deficiency Anemia in Infancy Is Associated with Altered Temporal Organization of Sleep States in Childhood

Long-term pathological consequences of prenatal infection: beyond brain disorders

Absence of Functional Peroxisomes from Mouse CNS Causes Dysmyelination and Axon Degeneration

Contact Info

Product

Resources

About