Chronic lung injury in the neonatal rat: Up-regulation of TGFβ1 and nitration of IGF-R1 by peroxynitrite as likely contributors to impaired alveologenesis

Belcastro, Rosetta; Lopez, Lianet; Li, Jun; Masood, Azhar; Tanswell, A. Keith

doi:10.1016/j.freeradbiomed.2014.12.011

Cited by 21 publications

(13 citation statements)

References 40 publications

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“…The role of insulin signaling in BPD is unclear, but low neonatal serum IGF-1 levels have been shown to be associated with the later development of BPD (Lofqvist et al, 2012). This evidence is consistent with cell and animal studies showing that IGF-1 signaling, mediating by NFKB, enhances collagen synthesis in fetal lung fibroblasts (Chetty et al, 2006), and that IGF-1 and IGFR1 regulate alveologenesis in neonatal rats (Belcastro et al, 2015). Whether this finding suggests novel strategies for BPD treatment, however, is an open question.…”

Section: Resultssupporting

confidence: 90%

Pathway centrality in protein interaction networks identifies functional mediators of pulmonary disease

Park

Hescott

Slonim

2017

Preprint

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SummaryIdentification of functional pathways mediating molecular responses may lead to better understanding of disease processes and suggest new therapeutic approaches. We introduce a method to detect such mediating functions using topological properties of protein-protein interaction networks. We introduce the concept of pathway centrality, a measure of communication between disease genes and differentially expressed genes. We find mediating pathways for three pulmonary diseases (asthma; bronchopulmonary dysplasia (BPD); and chronic obstructive pulmonary disease (COPD)) using pathway centrality. Mediating pathways shared by all three pulmonary disorders heavily favor inflammatory or immune responses and include specific pathways such as cytokine production, NF Kappa B, and JAK/STAT signaling. Disease-specific mediators, such as insulin signaling in BPD or homeostasis in COPD, are also highlighted. We support our findings, some of which suggest new treatment approaches, both with anecdotal evidence from the literature and via systematic evaluation using genetic interactions.peer-reviewed)

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Section: Resultssupporting

confidence: 90%

Pathway centrality in protein interaction networks identifies functional mediators of pulmonary disease

Park

Hescott

Slonim

2017

Preprint

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“…Hyperoxia inactivates IGF-1/IGF-1R signaling by attenuating their specific binding affinity in neonatal lungs or fetal lung distal epithelial cells, which further impairs lung cell proliferation, secondary crest formation, and alveologenesis [ 74 ]. The proteins and mRNA of IGF-1 and IGF-1R increase during hyperoxia lung injury and are highly abundant in ATII cells.…”

Section: Igf-1 Signaling In Lung Developmentmentioning

confidence: 99%

Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases

Wang

Guo

et al. 2018

BioMed Research International

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Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IGF-1 signaling modulates the development and differentiation of many types of lung cells, including airway basal cells, club cells, alveolar epithelial cells, and fibroblasts. IGF-1 signaling deficiency results in alveolar hyperplasia in humans and disrupted lung architecture in animal models. The components of IGF-1 signaling pathways are potentiated as biomarkers as they are dysregulated locally or systemically in lung diseases, whereas data may be inconsistent or even paradoxical among different studies. The usage of IGF-1-based therapeutic agents urges for more researches in developmental disorders and inflammatory lung diseases, as the majority of current data are collected from limited number of animal experiments and are generally less exuberant than those in lung cancer. Elucidation of these questions by further bench-to-bedside researches may provide us with rational clinical diagnostic approaches and agents concerning IGF-1 signaling in lung diseases.

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“…Pathomechanisms contributing to BPD are poorly understood. Genes upregulating during alveolarisation, followed by growth inhibitors, play an important role in the hyperoxia‐induced lung injury, as well as several other growth factors . We hypothesise that factors related to impaired lung growth among premature infants with cardiovascular malformations may have an impact on the development of adult PH.…”

Section: Discussionmentioning

confidence: 99%

Some neonatal risk factors for adult pulmonary arterial hypertension remain unknown

et al. 2015

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Chronic lung injury in the neonatal rat: Up-regulation of TGFβ1 and nitration of IGF-R1 by peroxynitrite as likely contributors to impaired alveologenesis

Cited by 21 publications

References 40 publications

Pathway centrality in protein interaction networks identifies functional mediators of pulmonary disease

Pathway centrality in protein interaction networks identifies functional mediators of pulmonary disease

Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases

Some neonatal risk factors for adult pulmonary arterial hypertension remain unknown

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