Chronic low-level arsenic exposure causes gender-specific alterations in locomotor activity, dopaminergic systems, and thioredoxin expression in mice

Bardullas, Ulises; Limón-Pacheco, Jorge H.; Giordano, Magda; Carrizales, Leticia; Mendoza-Trejo, M.S.; Rodríguez, Verónica

doi:10.1016/j.taap.2008.12.004

Cited by 97 publications

(53 citation statements)

References 72 publications

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“…Although it is not a new concept, the study of environmentally relevant doses (concentrations) has been the focus of recent attention (Bardullas et al, 2009;Kozul et al, 2009). Myers et al (2009) concluded that high dose experiments could not be used to predict low dose results.…”

Section: Discussionmentioning

confidence: 99%

Determination of environmentally relevant exposure concentrations of polybrominated diphenyl ethers for in vitro toxicological studies

Wei

Zhao

Liu

et al. 2010

Toxicology in Vitro

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a b s t r a c tToxicological studies at environmentally relevant concentrations are essential for understanding ecotoxic and health risks of pollutants such as polybrominated diphenyl ethers (PBDEs). However, no information is available on what exposure levels of PBDEs in vitro studies are environmentally relevant. We exposed MCF-7, HepG2, H295R and PC12 cells to BDE-47, and measured BDE-47 concentrations in the cells after exposure. We also used the percentile method to summarize literature data on environmental exposure levels of biotic tissues to PBDEs. The exposure concentration that resulted in a BDE-47 burden in cells close to the 90th percentile of PBDEs levels in tissues was assigned as the upper limit for the environmentally relevant concentration. Exposure to 1 nM BDE-47 resulted in PBDEs burdens in MCF-7, HepG2 and H295R cells close to the 90th percentile but PBDEs burdens in PC12 cells were higher than the 90th percentile. In consideration of the high exposure levels in PBDE-polluted areas, we concluded that the highest environmentally relevant exposure concentration of PBDEs in culture media should be approximately 10 nM for MCF-7, HepG2 and H295R cells, and <10 nM for PC12 cells. These results provide an approximate reference for setting environmentally relevant exposure concentrations of PBDEs for studies in vitro.

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Section: Discussionmentioning

confidence: 99%

Determination of environmentally relevant exposure concentrations of polybrominated diphenyl ethers for in vitro toxicological studies

Wei

Zhao

Liu

et al. 2010

Toxicology in Vitro

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“…In mice, inorganic arsenic in drinking water (0.05-5 mg/L, 4 months) led to sex-dependent alterations in dopaminergic markers, spontaneous locomotor activity and downregulation of the antioxidant capacity of the brain (Bardullas et al, 2009 (Arnold et al, 2003. Methylarsonate caused no clinical signs or brain lesions following chronic exposure of rats to 72.4 mg/kg b.w.…”

Section: Inorganic Arsenicmentioning

confidence: 99%

Scientific Opinion on Arsenic in Food

2009

EFSA Journal

856

220

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The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) assessed the risks to human health related to the presence of arsenic in food. More than 100,000 occurrence data on arsenic in food were considered with approximately 98 % reported as total arsenic. Making a number of assumptions for the contribution of inorganic arsenic to total arsenic, the inorganic arsenic exposure from food and water across 19 European countries, using lower bound and upper bound concentrations, has been estimated to range from 0.13 to 0.56 µg/kg bodyweight (b.w.) per day for average consumers, and from 0.37 to 1.22 µg/kg b.w. per day for 95 th percentile consumers. Dietary exposure to inorganic arsenic for children under three years of age is in general estimated to be from 2 to 3-fold that of adults. The CONTAM Panel concluded that the provisional tolerable weekly intake (PTWI) of 15 µg/kg b.w. established by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) is no longer appropriate as data had shown that inorganic arsenic causes cancer of the lung and urinary bladder in addition to skin, and that a range of adverse effects had been reported at exposures lower than those reviewed by the JECFA. The CONTAM Panel modelled the dose-response data from key for providing consumption information and calculating exposure, the partners of the EFSA project on the "Individual food consumption data and exposure" coordinated by Ghent University (Department of Public Health, University Hospital, Ghent University, Belgium), and RIKILT (Institute of Food Safety, Wageningen, The Netherlands) for the accessibility of the exposure assessment tools. 4 Table of contents shows now the fourth level of subheadings. 5 An error in the interpretation of the total number of the population in the study of Rahman et al. (2006a) was discovered (Table 41). The BMDL was recalculated and as a consequence it was not considered a potential reference point. The text in the opinion, Table 43 and Appendix were revised accordingly. In addition, the header of the "total number of cases" was replaced by "total number of individuals" in Tables 40-42 and the erroneous units were corrected to µg/L in the text below SUMMARYArsenic is a metalloid that occurs in different inorganic and organic forms, which are found in the environment both from natural occurrence and from anthropogenic activity. The inorganic forms of arsenic are more toxic as compared to the organic arsenic but so far most of the occurrence data in food collected in the framework of official food control are still reported as total arsenic without differentiating the various arsenic species. The need for speciation data is evident because several investigations have shown that especially in seafood most of the arsenic is present in organic forms that are less toxic. Consequently, a risk assessment not taking into account the different species but considering total arsenic as being present exclusively as inorganic arsenic would lead to a considerable overestimation of the health risk rel...

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“…Although developmental exposure to iAs can produce cognitive deficits in humans, the majority of the neurobehavioral studies conducted to date in animal models have focused on locomotor activity (Pryor et al, 1983;Itoh et al, 1990;Rodriguez et al, 2001;Rodriguez et al, 2002;Schultz et al, 2002;Bardullas et al, 2009). In a novel object exploration task, anxiety indices were…”

Section: Introductionmentioning

confidence: 99%

Locomotor activity and sensory – motor developmental alterations in rat offspring exposed to arsenic prenatally and via lactation

Gumilar

Lencinas

Bras

et al. 2015

Neurotoxicology and Teratology

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Please cite this article as: Fernanda Gumilar, Ileana Lencinas, Cristina Bras, Leda Giannuzzi, Alejandra Minetti, Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation, Neurotoxicology and Teratology (2015), doi: 10.1016/j.ntt.2015 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T an open field were assessed in 90-day-old offspring. Results show that rats exposed to low iAs concentrations through drinking water during early development evidence a delay in the development of sensory-motor reflexes. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPTBoth FOB procedure and open-field tests showed a decrease in locomotor activity in adult rats. This study reveals that exposure to the above-mentioned iAs concentrations produces dysfunction in the CNS mechanisms whose role is to regulate motor and sensory development and locomotor activity.

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Chronic low-level arsenic exposure causes gender-specific alterations in locomotor activity, dopaminergic systems, and thioredoxin expression in mice

Cited by 97 publications

References 72 publications

Determination of environmentally relevant exposure concentrations of polybrominated diphenyl ethers for in vitro toxicological studies

Determination of environmentally relevant exposure concentrations of polybrominated diphenyl ethers for in vitro toxicological studies

Scientific Opinion on Arsenic in Food

Locomotor activity and sensory – motor developmental alterations in rat offspring exposed to arsenic prenatally and via lactation

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