Chronic language deficits in children treated for posterior fossa tumour

Hudson, Lisa J; Murdoch, Bruce E.

doi:10.1080/02687039208248585

Cited by 22 publications

(11 citation statements)

References 38 publications

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“…The remaining subject demonstrated only word-finding deficits and difficulty on higher-level advanced language tasks, according to Murdoch and Hudson-Tennent (1994). While Hudson and Murdoch (1992a), together with more aggressive attempts by Hudson-Tennent and Murdoch (1993), failed to demonstrate impaired naming abilities as a group in children treated for posterior fossa tumour, seven of the subjects examined by Murdoch and Hudson-Tennent (1994) were reported to experience difficulty on tasks requiring naming ability.…”

Section: Specific Clinical Functions and Associated Clinical Changesmentioning

confidence: 93%

“…The most detailed group of studies of acquired language disorders associated with brain tumour diagnosis in children to date, however, were documented more than a decade ago by Hudson, Murdoch, and colleagues (Hudson & Murdoch, 1992a;Hudson, Murdoch, & Ozanne, 1989;Murdoch & Hudson-Tennent, 1994), who described the language abilities of children treated for posterior fossa tumours. While these findings were not discussed in relation to the direct impact of a tumour in this location, these authors reported clinical findings that are supported by more recent studies specifically investigating the direct impact of the cerebellum on language function.…”

Section: Specific Clinical Functions and Associated Clinical Changesmentioning

confidence: 97%

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Cerebellar language and cognitive functions in childhood: A comparative review of the clinical research

2003

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Background: Recent research addressing evidence from functional neuroimaging studies, neurophysiological research, and new advances in neuropsychology together with traditional cerebellar lesion studies have recently implicated the cerebellum in adult language and cognitive functions. However, more limited information is currently available in describing the functional connectivity present in the paediatric population. Aims: It is the purpose of this paper to review recent clinical research pertaining to paediatric populations, outlining the impact of site of lesion and specific associated clinical changes in children with cerebellar disturbances. Main contribution: The specific contribution of the right cerebellar hemisphere to language function is identified to also exist in the paediatric population, highlighting the existence of functional connections between this region of the brain and left frontal cortical areas early in development.Conclusions: Implications for future research in paediatric populations are extensive, as a greater awareness and an understanding of the recently acknowledged involvement of the cerebellum in cognition and nonmotor linguistic function is anticipated to also add new dimension and direction to the analysis of childhood language outcomes associated with the cerebellum.

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Section: Specific Clinical Functions and Associated Clinical Changesmentioning

confidence: 93%

Section: Specific Clinical Functions and Associated Clinical Changesmentioning

confidence: 97%

Cerebellar language and cognitive functions in childhood: A comparative review of the clinical research

2003

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“…Surprisingly, unlike neuropsychological effects that have been related to childhood radiation treatment of brain tumour, communication disorders have generally not been commonly linked to radiotherapy [6][7][8]26] . The one documented study that identified a possible connection reported language impairments inclusive of deficits in word finding, syntax and reading [8] .…”

Section: Discussion Of Casesmentioning

confidence: 99%

“…Results from the group of hemispheric patients also reportedly confirmed the dissociation of the circuits connecting the cerebellum to the supratentorial associative areas through the thalamus [3] . Specific high-level language deficits, global impairment, and expressive language and syntax were also acknowledged among others to be related to direct impact of cerebellar damage [6][7][8] .…”

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confidence: 99%

The Impact of a Cerebellar Tumour on Language Function in Childhood

Docking

Murdoch

Suppiah

2007

Folia Phoniatr Logop

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Background/Aims:Childhood-acquired cerebellar studies to date have appeared to present a concordant pattern of specific neuropsychological profiles depending on lesion site. The aim was to determine the impact of a cerebellar tumour specifically on language function in children by reporting both the general and high-level language abilities of 4 cases with differing sites of hemispheric and vermal involvement. Methods: The language abilities of 4 children (aged from 7 years 9 months to 13 years), treated with surgery and/or radiotherapy for cerebellar tumour 6 months to 3 years previously, were examined. A standardized battery of general and high-level language assessments was administered. Results: Analysis revealed intact abilities across all 4 cases on measures of general language, including receptive language, expressive language, receptive vocabulary and naming. While 2 of the 4 cases also demonstrated intact high-level language skills across all measures, the remaining 2 demonstrated specific deficits in linguistic problem solving at 6 months after treatment. Follow-up assessment of 1 case also demonstrated further decline in this area 12 months later. Conclusion: Findings of high-level language deficits in problem solving in 2 of the 4 cases examined supported previous reports of specific impairments in high-level language and in thinking flexibility and problem solving following cerebellar hemispheric damage in childhood.

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“…As previously outlined, the most extensive studies into the communication abilities of children following treatment for brain tumour to date have been carried out by Murdoch, Hudson, and colleagues [24][25][26][35][36][37][38]. In examining the language abilities of twenty children who had been treated for posterior fossa tumour, Murdoch and Hudson-Tennent [38] documented the only known reported case in which the language abilities of a child with brainstem involvement have been reported.…”

Section: Introductionmentioning

confidence: 99%

Language outcomes subsequent to treatment of brainstem tumour in childhood

Docking

Ward

Murdoch

2005

NRE

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While the occurrence and management of brainstem tumours in children would not traditionally indicate potential direct structural impact on classical language centres, recent theories have implicated some involvement of the brainstem in a functional language and cognitive neural loop between the cerebellum and the cerebral hemispheres. Thus, the present paper explored the impact of treatment for brainstem tumour on the general and high-level language abilities of six children treated for brainstem tumour, in addition to phonological awareness skills. Group analysis revealed that children treated for brainstem tumour demonstrated intact language and phonological awareness abilities in comparison to an age-and gender-matched control group. Individual analysis revealed only one of six children treated for brainstem tumour revealed evidence of language disturbances, with an additional child demonstrating an isolated mildly reduced score on one phonological awareness task. Language deficits identified in a child treated with a combination of both radiotherapy and chemotherapy were noted in the high-level language area of lexical generation. Findings highlighted that no overt language disturbances were evident in children treated for brainstem tumour. However, further analysis into higher-level language skills in the present study indicated that both general and high-level language abilities require long-term monitoring in this population.

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Chronic language deficits in children treated for posterior fossa tumour

Cited by 22 publications

References 38 publications

Cerebellar language and cognitive functions in childhood: A comparative review of the clinical research

Cerebellar language and cognitive functions in childhood: A comparative review of the clinical research

The Impact of a Cerebellar Tumour on Language Function in Childhood

Language outcomes subsequent to treatment of brainstem tumour in childhood

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