Chronic Kidney Disease: The Silent Epidemy

Bellasi, Antonio; Lullo, Luca Di; Iorio, Biagio Di

doi:10.3390/jcm8111795

Cited by 16 publications

(16 citation statements)

References 32 publications

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“…Chronic kidney disease (CKD) is associated with poor prognosis [ 1 ]. At the same time in patients with atrial fibrillation (AF) impaired renal function is independently related to stroke or systemic embolism [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Chronic Kidney Disease and Its Impact on a Prothrombotic State in Patients with Atrial Fibrillation

Matusik

Heleniak

Papuga-Szela

et al. 2020

JCM

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It is unclear whether chronic kidney disease (CKD) increases thromboembolism in atrial fibrillation (AF). We conducted a retrospective cross-sectional analysis of 502 non-anticoagulated AF patients (median age, 66 (60–73) years, median CHA2DS2-VASc score, 3.0 (2.0–4.0)) with an estimated glomerular filtration rate (eGFR) ≥ 15 mL/min/1.73 m2. Endogenous thrombin potential (ETP), clot permeability (Ks), and clot lysis time (CLT), among others, were determined. Patients with stage 4 CKD (n = 87; 17.3%) had higher ETP and prolonged CLT compared with those with stage 3 CKD. In patients with stages 3 to 4 CKD (n = 180; 35.9%) N-terminal pro-B-type natriuretic peptide predicted low Ks (the lowest quartile, odds ratio [OR] per 100 pg/mL: 1.03, 95% confidence interval [CI]: 1.01–1.06) and prolonged CLT (the top quartile, OR per 100 pg/mL: 1.05, 95% CI: 1.02–1.08), but not high ETP. In the whole cohort, after adjustment for CHA2DS2-VASc score, stage 4 CKD, but not stage 3 CKD, predicted high ETP (OR: 9.06; 95% CI: 4.44−18.46) and prolonged CLT (OR: 3.58; 95% CI: 1.76–7.28), but not low Ks. compared to the reference eGFR category. This study is the first to demonstrate the prothrombotic and antifibrinolytic alterations in AF patients with stage 4 CKD, but not stage 3 CKD irrespective of clinical stroke risk factors.

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Section: Introductionmentioning

confidence: 99%

Chronic Kidney Disease and Its Impact on a Prothrombotic State in Patients with Atrial Fibrillation

Matusik

Heleniak

Papuga-Szela

et al. 2020

JCM

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“…Many metabolic abnormalities may promote the development of CKD. Preclinical examination has great advantages in preventing CKD from progressing to end-stage renal disease (ESRD) [11]. The present study aimed to describe distribution characteristics of four renal function indicators in the population, including CysC, UA, Cr and UN.…”

Section: Discussionmentioning

confidence: 99%

“…Early identi cation and treatment of CKD can help prevent or reduce the risk for CKD-related complications [6]. Indeed, a decline in renal function may lead to the accumulation of toxins and have harmful effects on various metabolic pathways, including the progression of in ammation and kidney damage [11]. Thus, it is necessary to measure and monitor renal function of the population.…”

Section: Introductionmentioning

confidence: 99%

Analysis of renal function in a Health Examination Population in Chengdu (2012-2018)

Bao

Yang

et al. 2020

Preprint

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Background Dysfunction of kidney correlates with multiple renal diseases, for instance, chronic kidney disease. However, monitoring the changes of indexes related to renal function may help to early find the potential patients with renal diseases. Methods A cohort of 14,716 participants (8,148 males and 6,568 females) was recruited from the Health Examination Center at West China Hospital, Sichuan University, and was followed up since 2012 to 2018. Four indexes related to renal function, including creatinine (Cr), uric acid (UA), cystatin C (CysC) and urea nitrogen (UN) were selected to monitor the kidney function. Results Levels of CysC, Cr were reduced, and expression of UA was increased in all the participants since 2012 to 2018 overall. In addition, levels of CysC, UA, Cr and UN were higher in males than those in females, and expression of the four indexes was up-regulated in the elderly population compared with those in the younger population since 2012 to 2018 overall. Conclusions The findings suggested that some preventive action may be adopted early and more attention can focus on the health-examination population.

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“…Its prevalence is increasing dramatically, and it threatens human health and quality of life. Currently, about 8–10% of the world's population has a certain degree of CKD and is the 16th most frequent cause of mortality each year 1 , 2 . Unfortunately, the increasing cost of treating CKD and its complications has placed a considerable economic burden on health care systems worldwide 3 .…”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, the increasing cost of treating CKD and its complications has placed a considerable economic burden on health care systems worldwide 3 . However, in the early and middle stages of CKD, patients generally do not exhibit any noticeable signs or symptoms 1 . The current diagnostic biomarkers (serum creatinine and urine albumin) are not enough to predict the development of CKD.…”

Section: Introductionmentioning

confidence: 99%

Changes of protein levels in human urine reflect the dysregulation of signaling pathways of chronic kidney disease and its complications

Hao

Reyes

Morris

et al. 2020

Sci Rep

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The increasing prevalence of chronic kidney disease (CKD) seriously is threatening human health and overall quality of life. The discovery of biomarkers of pathogenesis of CKD and the associated complications are very important for CDK diagnosis and treatment. In this paper, urine protein biomarkers were investigated because urine sample collection is convenient and non-invasive. We analyzed the protein concentrations in the urine of CKD patients and extracted abnormal protein signals comparing with the healthy control groups. The enriched signaling pathways that may characterize CKD pathology were identified from these proteins. We applied surface-enhanced laser desorption and ionization time of flight mass spectrometry technology to detect different protein peaks in urine samples from patients with CKD and healthy controls. We searched the proteins corresponding to protein peaks through the UniProt database and identified the signaling pathways of CKD and its complications by using the NIH DAVID database. 42 low abundance proteins and 46 high abundance proteins in the urine samples from CKD patients were found by comparing with healthy controls. Seven KEGG pathways related to CKD and its complications were identified from the regulated proteins. These pathways included chemokine signaling pathway, cytokine–cytokine receptor interaction, oxidative phosphorylation, cardiac muscle contraction, Alzheimer’s disease, Parkinson's disease, and salivary secretion. In CKD stages 2, 3, 4, and 5, five proteins showed significantly differential abundances. The differential protein signals and regulated signaling pathways will provide new insight for the pathogenesis of CKD and its complications. These altered proteins may also be used as novel biomarkers for the noninvasive and convenient diagnosis methods of CKD and its complications through urine testing in the future.

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Chronic Kidney Disease: The Silent Epidemy

Abstract: Numerous observations suggest that chronic kidney disease (CKD) is an epidemic condition [...]

Cited by 16 publications

References 32 publications

Chronic Kidney Disease and Its Impact on a Prothrombotic State in Patients with Atrial Fibrillation

Chronic Kidney Disease and Its Impact on a Prothrombotic State in Patients with Atrial Fibrillation

Analysis of renal function in a Health Examination Population in Chengdu (2012-2018)

Changes of protein levels in human urine reflect the dysregulation of signaling pathways of chronic kidney disease and its complications

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