Chronic Kidney Disease-Mineral and Bone Disorders (CKD-MBD)

Mosbah, Osama

doi:10.26502/anu.2644-2833008

Cited by 6 publications

(5 citation statements)

References 57 publications

(83 reference statements)

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“…In the final stages of CKD, FGF-23 shows a positive connection to cardiovascular incidents and is considered as a predictive risk indicator. For patients undertaking peritoneal dialysis, FGF-23 molar concentration shows a positive connection to the left ventricular hypertrophy 2,16,17 .…”

Section: Role Of Fgf-23mentioning

confidence: 99%

Acid-base disorders and the impact on metabolic bone disease in hemodialysis patients

Evaggelou¹,

Lambrou²

2021

JRPMS

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tendon rupture, and frequent occurrence of fractures 5,6 .We use the term Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) to describe a wider clinical syndrome that is developed as a systemic metabolic mineral bone disturbance, as a result of the chronic kidney Abstract Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) is a term that is used to describe a wider clinical syndrome that can be developed as a systemic metabolic mineral bone disturbance, due to the chronic kidney disease, and it manifests itself as metabolic mineral bone anomalies or extra-skeletal calcifications. Metabolic acidosis is considered to be the most widespread acid-base disorder that is found in the majority of CKD patients. Hemodialysis patients seem to be more prone to MBD due to acid base disorders. This article aims to review the available literature about the acid-base disorders and their impact on MBD in hemodialysis patients. We have conducted an electronic literature research, where titles and abstracts of relevant papers were validated by the authors for further inclusion in this work. Finally, full texts of the included articles were retrieved. The findings of our literature research have concluded that at the age of 55, the relative risk of hip fractures increases and in CKD patients is high; after 4 years of undergoing dialysis, the age-specific relative risk of suffering a hip fracture was 9.83 for males and 8.10 for females. The average relative risk of mortality associated with hip fracture was 1.99. Our review has highlighted that CKD and MBD are closely related and they consist of a phenomenon requiring further research.

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Section: Role Of Fgf-23mentioning

confidence: 99%

Acid-base disorders and the impact on metabolic bone disease in hemodialysis patients

Evaggelou¹,

Lambrou²

2021

JRPMS

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“…Mixed renal osteodystrophy Combined mineralization defects and high bone turnover defects. 10 These alterations in bone turnover contribute to decreased skeletal mechanical competence, which can result in fractures and diminished capacity to bear loads. The most common fractures are fragility fractures of the vertebrae, femoral neck of the hip, or the wrist (Colles fractures).…”

Section: Pathophysiologymentioning

confidence: 99%

Prevalence of Mineral Bone Disease in Dialysis Patients

Rizvi¹,

Tasleem²,

Altaf³

2021

Pak J Kidney Dis

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Progressive loss of kidney function in chronic kidney disease (CKD) leads to reduced production of 1-α-(OH)2-D3 (1,25-dihydroxyvitamin D; calcitriol) and abnormal mineral homeostasis leading to bone mineral disorders. The disorder starts with stage 2 CKD but manifests itself as the disease progresses until stage 3 CKD. Material and methods This study was carried out on 61 patients with end-stage renal disease on regular HD at our Centre. After obtaining informed consent, complete blood count, blood urea level, serum creatinine level, albumin level, uric acid level, Ca level, phosphate level, alkaline phosphatase level, and PTH level were done. Results Out of 60 patients 41 (68.33%) were high bone turnover,10 (16.6%) were normal bone turnover whereas 9(15%) were low bone turnover. Conclusion The prevalence of CKD-MBD among dialysis patients is 83.33% at our center and needs proper monitoring by routine investigations including serum phosphate, calcium, vitamin D levels and most importantly i-PTH levels according to guidelines.

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“…There was insignificant difference in ALP level between the two assessments. "Mosbah 2019 reported that" total ALP can be used as bone marker, although it is not the best marker for bone turnover [13]. An immunoassay for bone specific ALP is a better marker but not in standard practice.…”

Section: [Iv] Comparison Between Patient Comorbidities In Relation To...mentioning

confidence: 99%

Urea Percentile Curves in Pre-dialysis Children with Chronic Kidney Disease: Efficacy & Limitations.

Moustafa

Habib²,

Sayed

2021

GEGET

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Introduction: Chronic kidney disease (CKD) carries a lot of co-morbidities. Urea rise may be related to decline in glomerular filtration rate, under nutrition or hyper catabolic state. According to urea percentile curves (UPC), patients with a given glomerular filtration rate show wide range of urea levels. Correlation between urea percentiles and CKD patients' co-morbidities was suggested in many studies since Montini 2003.Aim of the study: to evaluate the value of UPCs as a simple tool in monitoring metabolic status and progress of CKD comorbidities. Methods: Retrospective revision of patients' files for their urea levels and GFR at the time of diagnosis and long period after (follow-up). Accordingly, each patient was plotted on UPC graph to determine his urea percentile (UP) at each setting. Patients were classified according to their urea percentile as low, moderate and high UP groups, and classified according to urea percentile progress pattern as ascending, descending and stable groups. Correlations between their co-morbidities and their urea percentiles were statistically analysed. Results: showed correlation between morbidity markers changes in relation to progress course of UP with significant differences in the values of phosphorus rise, bicarbonate changes and frequency of hyperphosphatemia between the 3 groups of urea percentile progress pattern. Conclusion: Follow up pattern of urea percentile in these children is a simple and helpful tool in monitoring their co-morbidities.

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Chronic Kidney Disease-Mineral and Bone Disorders (CKD-MBD)

Cited by 6 publications

References 57 publications

Acid-base disorders and the impact on metabolic bone disease in hemodialysis patients

Acid-base disorders and the impact on metabolic bone disease in hemodialysis patients

Prevalence of Mineral Bone Disease in Dialysis Patients

Urea Percentile Curves in Pre-dialysis Children with Chronic Kidney Disease: Efficacy & Limitations.

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