Chronic Kidney Disease is Associated With Upper Tract Urothelial Carcinoma

Abstract

Supplemental Digital Content is available in the text

Risks of female genital tract related cancers (gynecological cancers) or breast cancer in women with and without chronic kidney disease

“…The most important strength of the current study was unlikely to the well-known higher risk of upper tract urothelial carcinoma in the CKD women in the world, including Taiwan, [ 6 , 16 , 20 – 26 , 69 ] and it might be the first nationwide, population-based study to investigate the risk of GC in the CKD women in Asia. In addition, using this national population-based study, we further confirmed that GC is an age-dependent disease.…”

Is preoperative chronic kidney disease status associated with oncologic outcomes in upper urinary tract urothelial carcinoma? A multicenter propensity score-matched analysis

“…Patients with low preoperative eGFR ( < 60 mL/min/1.73m 2 ) had worse RFS, CSS, and OS than those with higher eGFR (≥60 mL/min/1.73m 2 ). Despite the fact that the exact mechanisms by which relative renal insufficiency leads to UTUC, and possibly to more aggressive UTUC, are unknown, there is some evidence from a population-based cohort study that demonstrates the association between decreased renal function and risk of urinary tract cancer including UTUC [ 12 - 14 ]. CKD is common in the elderly population and is suggested as an important risk factor for the development of many cancers including those of the prostate and urinary tract [ 12 ].…”

“…Among 267 patients with urothelial carcinoma, 11%, 55%, and 71% of those with none/mild CKD, CKD stage III, and CKD stage IV/V, respectively, had UTUC. Recently, a more large-scale and long-term follow-up study using a national health database in Taiwan demonstrated that CKD patients have an elevated risk for UTUC [ 14 ]. In the multivariate analysis, CKD patients had a 1.63-fold higher risk of UTUC than the non-CKD group (adjusted HR: 1.63, 95% CI: 1.26-2.13).…”

“…Among these variables, tumor stage and lymphovascular invasion were also independent prognostic factors for oncological outcomes in this study. Therefore, CKD may be related to aggressive UTUC [ 14 ].…”

Infant stool color card screening helps reduce the hospitalization rate and mortality of biliary atresia

“…In the articles “Infant stool color card screening helps reduce the hospitalization rate and mortality of biliary atresia: A 14-year nationwide cohort study in Taiwan” [1] and “Chronic kidney disease is associated with upper tract urothelial carcinoma: A nationwide population-based cohort study in Taiwan”, [2] which appeared in Volume 95, Issue 12 and Volume 95, Issue 14, respectively, of Medicine , a university affiliation was originally given incorrectly. Dr. Chen's affiliation in both articles should have read “Department of Pediatrics (SC-CC), School of Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan”.…”