Chronic kidney disease in children and the role of epigenetics: Future therapeutic trajectories

Uwaezuoke, Samuel N; Okafor, Henrietta U.; Muoneke, Vivian N.; Odetunde, Odutola Israel; Odimegwu, Chioma Laura

doi:10.3892/br.2016.781

Cited by 4 publications

(5 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chronic kidney disease (CKD) has recently emerged as a global health burden; its worldwide prevalence has been estimated to range between 8 and 16% which could cause millions of mortalities annually [1]. Risk factors influencing CKD are divided into two main subgroups: Environment and genetics factors.…”

Section: Introductionmentioning

confidence: 99%

Dietary pattern and incidence of chronic kidney disease among adults: a population-based study

et al. 2018

View full text Add to dashboard Cite

Background & AimsAlthough dietary patterns have been linked to chronic diseases such as cardiovascular disease, sparse data are available for a relationship between dietary patterns and incident chronic kidney disease (CKD) in West Asian populations. The aim of this study was to evaluate the association of population-based dietary pattern with the risk of incident CKD after 6.1 years of follow-up.MethodsAt baseline, habitual dietary intakes of 1630 participants of the Tehran Lipid and Glucose Study (TLGS) who were free of CKD was assessed by a valid and reliable food-frequency questionnaire. The following three major dietary patterns were identified using a principal components analysis: Lacto-vegetarian dietary pattern, traditional Iranian dietary pattern, and high fat, high sugar dietary pattern. Estimated glomerular filtration rate (eGFR) was calculated, using the Modification of Diet in Renal Disease (MDRD) Study equation and CKD was defined as eGFR < 60 mL/min/1.73m2. Odds ratio (OR) using multivariable logistic regression was calculated for the association of incident CKD with the extracted dietary patterns.ResultsAfter adjusting for age, sex, smoking, total energy intake, physical activity, body mass index, diabetes, and hypertension the OR for participants in the highest compared with those in the lowest tertile of the lacto-vegetarian dietary pattern was 0.57 (95% confidence interval [CI]: 0.41 to 0.80, P-trend = 0.002). In contrast, the high fat, high sugar dietary pattern was positively associated with the incidence of CKD (OR for the third tertile compared with first tertile: 1.46; 95% CI: 1.03–2.09; P-trend = 0.036). Traditional Iranian dietary pattern was not associated with incident CKD.ConclusionThe high fat, high sugar dietary pattern was associated with significantly increased (46%) odds of incident CKD, whereas a lacto-vegetarian dietary pattern may be protective against the occurrence of CKD by 43%.Electronic supplementary materialThe online version of this article (10.1186/s12986-018-0322-7) contains supplementary material, which is available to authorized users.

show abstract

Section: Introductionmentioning

confidence: 99%

Dietary pattern and incidence of chronic kidney disease among adults: a population-based study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Approximately 25% of incident dialysis patients have close relatives with CKD ( Freedman et al, 2005 ), and the distinct susceptibilities of different rodent strains to experimental CKD strongly suggests that genetic variations impact renal fibrogenesis ( Kokeny et al, 2009 ). Likewise, familial clustering and disparities in prevalence of CKD across race suggest a strong genetic component to progression ( Uwaezuoke et al, 2016 ). However, identifying relevant polymorphisms in human kidney disease has been somewhat disappointing to date ( Tampe and Zeisberg, 2014 ).…”

Section: Factors Affecting the Progression Of Fibrosismentioning

confidence: 99%

Progression of Tubulointerstitial Fibrosis and the Chronic Kidney Disease Phenotype – Role of Risk Factors and Epigenetics

Hewitson¹,

Holt²,

Smith³

2017

Front. Pharmacol.

View full text Add to dashboard Cite

Although the kidney has capacity to repair after mild injury, ongoing or severe damage results in scarring (fibrosis) and an associated progressive loss of kidney function. However, despite its universal significance, evidence highlights a population based heterogeneity in the trajectory of chronic kidney disease (CKD) in these patients. To explain the heterogeneity of the CKD phenotype requires an understanding of the relevant risk factors for fibrosis. These factors include both the extrinsic nature of injury, and intrinsic factors such as age, gender, genetics, and perpetual activation of fibroblasts through priming. In many cases an additional level of regulation is provided by epigenetic mechanisms which integrate the various pro-fibrotic and anti-fibrotic triggers in fibrogenesis. In this review we therefore examine the various molecular and structural changes of fibrosis, and how they are influenced by extrinsic and intrinsic factors. Our aim is to provide a unifying hypothesis to help explain the transition from acute to CKD.

show abstract

“…Chronic kidney Disease (CKD) is described as the availability of kidney damage or decreased renal function that lasts for three months or more, regardless of its cause. This disease, which is common worldwide (8% -16%), is a global health problem that causes millions of deaths each year (1). There are two primary important risk factors for CKD; genetic, environmental.…”

Section: Introductionmentioning

confidence: 99%

Kurban Bayramında Yoğun Et Tüketimi Kronik Böbrek Hasarını Hızlandırır mı? Yoğun Et Tüketiminin Kronik Böbrek Hastalığına Etkisi

Karataş

Çanakçı

Kaya

et al. 2021

Konuralp Tıp Dergisi

View full text Add to dashboard Cite

Objective: Chronic kidney disease (CKD) is precisely described as the availability of kidney damage or decreased kidney fonction that lasts for three months or more, regardless of its cause. Dietary factors may affect the progression and complications of the disease. Our aim is to investigate the effects of excessive meat consumption of Muslims on CKF during the Feast of Sacrifice. Methods: The study was performed on 203 patients with stage III-V CKD. The biochemical values of the patients who applied to the nephrology outpatient clinic at least one month before and one month after the Eid al-Adha were recorded. Patients who regularly consumed sacrificial meat for 4 days during the feast of sacrifice were included in the study. Results: The blood urea nitrogen (BUN), creatinine, albumin, potassium (K), calcium (Ca), vitamin D, and base excess (BE) levels of the patients were foundap to be significantly higher after the Feast of Sacrifice (p=0.014, p<0.001, p=0.031, p<0.001, p=0.002, p<0.001and p=0.009). The mean e-GFR of the patients before the Feast of Sacrifice was 32.221±14.756. It was found to be 31.474±15.229 after the feast of sacrifice, indicating a statistically significant decrease (p=0.042). A slight decrease was observed in the blood pH (p=0.002) and bicarbonate (HCO3) (p=0.002) levels of the patients. The change in the amount of creatinine with the feast showed a significant difference by CKD stages (p<0.001). There was no significant difference between stage IIIa (0.066±0.191), stage IIIb (0.067±0.318) and stage IV (0.137±0.547) patients (p>0.05). In stage V patients, creatinine level (0.580±1.124) showed a significant increase (p<0.001) due to the short-term intense meat consumption during the Feast of Sacrifice. Conclusions: In this study, we observed a progressive deterioration in kidney function due to high protein diet caused by excessive meat consumption in a short time during the feast of sacrifice.

show abstract

Chronic kidney disease in children and the role of epigenetics: Future therapeutic trajectories

Cited by 4 publications

References 50 publications

Dietary pattern and incidence of chronic kidney disease among adults: a population-based study

Dietary pattern and incidence of chronic kidney disease among adults: a population-based study

Progression of Tubulointerstitial Fibrosis and the Chronic Kidney Disease Phenotype – Role of Risk Factors and Epigenetics

Kurban Bayramında Yoğun Et Tüketimi Kronik Böbrek Hasarını Hızlandırır mı? Yoğun Et Tüketiminin Kronik Böbrek Hastalığına Etkisi

Contact Info

Product

Resources

About