Chronic kidney disease in children: an update

Abstract

Chronic kidney disease (CKD) is a major healthcare issue worldwide. However, the prevalence of pediatric CKD has never been systematically assessed and consistent information is lacking in this population. The current definition of CKD is based on glomerular filtration rate (GFR) and the extent of albuminuria. Given the physiological age-related modification of GFR in the first years of life, the definition of CKD is challenging per se in the pediatric population, resulting in high risk of underdiagnosis in this population, treatment delays and untailored clinical management. The advent and spreading of massive-parallel sequencing technology has prompted a profound revision of the epidemiology and on the causes of CKD in children, supporting the hypothesis that CKD is much more frequent than currently reported in children and adolescents. This acquired knowledge will eventually converge in the identification of the molecular pathways and cellular response to damage, with new specific therapeutic targets to control disease progression and clinical features of children with CKD. In this review, we will focus on recent innovations in the field of pediatric CKD and in particular those where advances in knowledge have become available in the last years, to the aim of providing a new perspective on CKD in children and adolescents.

Blood cell indices and inflammation-related markers with kidney cancer risk: a large-population prospective analysis in UK Biobank

“…Kidney cancer, also known as renal cancer, is a disease that is becoming more common globally, with over 400,000 new cases reported each year. The mortality rate for kidney cancer is also high, with around 175,000 fatalities occurring annually worldwide (5)(6)(7)(8). Despite its frequency, kidney cancer remains a complex and heterogeneous disease, characterized by challenges in early detection, limited treatment options, and an inadequate understanding of its underlying mechanisms (9).…”

Demographic and Clinical Parameters Along with Hormonal Levels in Pediatric Patients with Chronic Kidney Disease: A Study of Pubertal Development Impacts

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