Chronic Kidney Disease Distinctly Affects Relationship Between Selenoprotein P Status and Serum Thyroid Hormone Parameters

Reinhardt, Walter; Dolff, Sebastian; Benson, Sven; Broecker-Preuß, Martina; Behrendt, Stefan; Hög, Antonia; Führer, Dagmar; Schomburg, Lutz; Köhrle, Josef

doi:10.1089/thy.2015.0097

Cited by 14 publications

(5 citation statements)

References 39 publications

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“…Alteration in selenoprotein homeostasis in CKD patients affecting thyroid hormone profile has been studied by Reinhardt et al . [ 19 ] Selenoprotein P is the major selenium transport protein representing the selenium status in the body. They observed that in patients with chronic renal disease, selenoprotein P had negative correlation with T4 levels, both total and free hormones.…”

Section: Discussionmentioning

confidence: 99%

Correlation of thyroid hormone profile with biochemical markers of renal function in patients with undialyzed chronic kidney disease

Srivastava

Rajput

Shrivastava

et al. 2018

Indian J Endocr Metab

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Objective:The present study was conducted to evaluate the correlation of renal functions with thyroid hormone levels in patients with undialyzed chronic kidney disease (CKD). Literature shows significant alteration in thyroid hormone function tests in CKD patients who are receiving long-standing dialysis treatment. However, not much is described in those receiving conservative management without dialysis. Although CKD is associated with an increased prevalence of primary hypothyroidism, various studies on thyroid hormone status in uremic patients have reported conflicting results.Methodology:Thyroid hormone levels and biochemical markers of renal function were estimated in 30 undialyzed CKD patients and similar number of age- and sex-matched healthy controls, followed by statistical analysis and correlation.Results:Free triiodothyronine (FT3) and free thyroxine (FT4) were found to be significantly reduced (P < 0.001 for each) in undialyzed CKD patients whereas thyroid-stimulating hormone (TSH) levels showed statistically insignificant alteration in both groups. We also observed that urea and creatinine were negatively correlated whereas creatinine clearance was positively correlated with both FT3 and FT4 having high statistical (two tailed) significance with P < 0.001. Nonsignificant correlation was seen between blood urea and TSH (r = 0.236, P = 0.069), creatinine clearance, and TSH (r = 0.206, P = 0.114 Pearson's correlation coefficient). There is just significant positive correlation between the serum creatinine values and TSH (r = 0.248, P = 0.049).Conclusions:Thyroid hormones were significantly decreased in undialyzed CKD patients as compared to healthy controls.

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Section: Discussionmentioning

confidence: 99%

Correlation of thyroid hormone profile with biochemical markers of renal function in patients with undialyzed chronic kidney disease

Srivastava

Rajput

Shrivastava

et al. 2018

Indian J Endocr Metab

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“…Inclusion and exclusion criteria: Patients examined in our outpatient clinic for further work-up of presumed kidney damage were evaluated prospectively as previously published to examine the link between selenoprotein P, thyroid hormone, and renal impairment [ 28 ]. Thus, serum samples were drawn from July 2013 to July 2014.…”

Section: Methodsmentioning

confidence: 99%

Association between albuminuria and thyroid function in patients with chronic kidney disease

et al. 2021

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Purpose The relationship between proteinuria and thyroid function remains controversial in patients with chronic kidney disease (CKD). We prospectively investigated the association between kidney and thyroid function in thyroid antibody-negative patients through all CKD stages. Methods We enrolled 184 nondialysis patients (mean age: 63.1 ± 16.9 years) without previous thyroid disease or thyroid-specific antibodies. Kidney function was assessed by estimating the glomerular filtration rate (eGFR) classified according KDIGO (CKD G1–5). Kidney damage was assessed by albuminuria (albumin-to-creatinine ratio, ACR) and classified as mild, moderate, or severe (ACR1: <300, ACR2: 300–3000, and ACR3: 3000 mg/g). To evaluate thyroid function, TSH, T4, fT4, T3, fT3, reverse T3 (rT3), and thyroxine-binding globulin (TBG) were measured. Results rT3 concentrations correlated negatively with albuminuria (r = −0.286, p < 0.001) and were significantly lower in patients with severe albuminuria than in those with mild or moderate albuminuria (ACR3: 0.28 vs. ACR2: 0.32 vs. ACR1: 0.36 nmol/l, p < 0.001). The severity of albuminuria revealed no impact on TSH, fT4, T3, fT3, and TBG. EGFR correlated with increasing T4, fT4, T3, fT3, and TBG (T4: r = 0.289, p < 0.01; fT4: r = 0.196, p < 0.01; T3: r = 0.408, p < 0.01; fT3: r = 0.390, p < 0.01) but not with rT3. Conclusions In thyroid antibody-negative patients presenting advanced CKD (stages 4 and 5), even severe kidney protein loss failed to influence thyroid hormone status. However, albuminuria severity correlated negatively with rT3, which was significantly lower in patients with albuminuria in the nephrotic range.

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“…According to Reinhardt and colleagues, in patients with CKD, SeP concentrations increase with impaired renal function (even after correction for age and CRP concentrations), whereas SeP concentrations are significantly lower in dialysis patients [187]. The reasons for the discrepant SeP concentrations among the stages of chronic renal failure are not yet completely defined, though the increased inflammatory status in dialysis patients [188] could play an important pathogenic role.…”

Section: Liver-released Compoundsmentioning

confidence: 99%

Pathophysiology of Non Alcoholic Fatty Liver Disease

Petta

Gastaldelli

Rebelos

et al. 2016

IJMS

142

105

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The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circulating lipids, mediators released by adipose, muscle and liver tissues and pancreatic and gut hormones in relation to diet, exercise and inflammation.

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Chronic Kidney Disease Distinctly Affects Relationship Between Selenoprotein P Status and Serum Thyroid Hormone Parameters

Cited by 14 publications

References 39 publications

Correlation of thyroid hormone profile with biochemical markers of renal function in patients with undialyzed chronic kidney disease

Correlation of thyroid hormone profile with biochemical markers of renal function in patients with undialyzed chronic kidney disease

Association between albuminuria and thyroid function in patients with chronic kidney disease

Pathophysiology of Non Alcoholic Fatty Liver Disease

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