Chronic Kidney Disease Diagnosis and Management

Chen, Teresa K.; Knicely, Daphne H.; Grams, Morgan E.

doi:10.1001/jama.2019.14745

Cited by 1,051 publications

(854 citation statements)

References 117 publications

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“…A further intriguing question, unable to be directly posed in the present study, is the possibility that medications used for the treatment of type 2 diabetes may impact the risk for, or severity of, PTSD. Angiotensin‐converting enzyme (ACE) inhibitors as well as angiotensin receptor blockers (ARBs) have well‐validated utility in preventing or slowing the progression of diabetes‐related kidney disease . Interestingly, prescription of either ACE inhibitors or ARBs, but not other antihypertensive medications, has been associated with reduced PTSD symptom severity when controlling for level of prior childhood and adult trauma exposure and demographic variables in participants recruited from a heavily trauma‐exposed primary care population .…”

Section: Discussionmentioning

confidence: 99%

Trauma exposure and stress‐related disorders in African‐American women with diabetes mellitus

Dixon

Michopoulos

Gluck

et al. 2020

Endocrino Diabet & Metabol

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Objective:The purpose of the study was to assess demographic features, rates of trauma exposure, prevalence of post-traumatic stress and depressive symptoms in a group of urban, low-income, African-American women with type 1 or type 2 diabetes mellitus. Research Design and Methods:We conducted a survey of (n = 290) low-income, African-American women seeking care in the diabetes clinic of an urban hospital and collected data on the demographic characteristics, childhood and nonchildhood abuse trauma exposure, and the severity of post-traumatic stress and depressive symptoms using the Post-traumatic Stress Disorder (PTSD) Symptom Scale (PSS) and the Beck Depression Inventory (BDI). In a subset of women with type 2 diabetes (n = 96), we assessed haemoglobin A1c to examine the relationship between psychopathology and glycaemic control. Results:Of the overall sample, 61.7% reported exposure to trauma in their lifetime, and 30.4% and 29.3% had current PTSD and MDD, respectively. Exposure to both childhood and nonchildhood abuse trauma was associated with an increased PTSD and depressive symptom severity (P's < .05). PTSD diagnosis, but not depression, was associated with increased haemoglobin A1c (P = .002). Conclusions:These data document high levels of trauma exposure, PTSD and depressive symptoms in diabetic African-American women treated in a specialty clinic of an urban hospital setting. Furthermore, these data indicate that the presence of PTSD is negatively associated with glycaemic control. K E Y W O R D S diabetes, glycaemic control, MDD, PTSD, trauma exposure How to cite this article: Dixon HD, Michopoulos V, Gluck RL, et al. Trauma exposure and stress-related disorders in African-American women with diabetes mellitus. Endocrinol

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Section: Discussionmentioning

confidence: 99%

Trauma exposure and stress‐related disorders in African‐American women with diabetes mellitus

Dixon

Michopoulos

Gluck

et al. 2020

Endocrino Diabet & Metabol

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“…Chronic kidney disease (CKD) affects approximately 10% of the global population (1) and is a major risk factor for end-stage kidney disease and cardiovascular disease (2)(3)(4). It is characterised by the progressive loss of renal filtrative capacity, with functional renal tissue replaced by excess extracellular matrix (ECM).…”

Section: Introductionmentioning

confidence: 99%

Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease

Conway

O’Sullivan

Cairns

et al. 2020

Preprint

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Short running title: Myeloid cell heterogeneity in kidney injury and repair Corresponding authors: Bryan Conway (Bryan.Conway@ed.ac.uk), Eoin O'Sullivan (Eoin.osullivan@ed.ac.uk), Tamir Chandra (Tamir.Chandra@ed.ac.uk) Laura Denby (Laura.Denby@ed.ac.uk) Word Count = 4810 Number of figures = 8 2 AbstractThe kidney has a limited capacity to repair following injury, however, the endogenous reparative pathways are not well understood. Here we employ integrated droplet-and platebased scRNA-seq in the murine reversible unilateral ureteric obstruction model to dissect the transcriptomic landscape at the single cell level during renal injury and resolution of fibrosis.We generate a comprehensive catalogue of the changes induced during injury and repair, revealing significant myeloid cell heterogeneity, which would not have been identifiable by conventional flow cytometry. We identify new markers for the myeloid populations within the kidney as well as identification of novel subsets including an Arg1 + monocyte population specific to early injury and a Mmp12 + macrophage subset exclusive to repair. Finally, using paired blood exchange to track circulating immune cells, we confirm that monocytes are recruited to the kidney early after injury and are the source of Ccr2 + macrophages that accumulate in late injury. Our data demonstrate the utility of complementary technologies to identify novel myeloid subtypes that may represent therapeutic targets to inhibit progression or promote regression of kidney disease. Methods Animal modelsAll protocols and surgical procedures were approved by the Animal Ethics Committee, University of Edinburgh. Animal experiments were conducted in accordance with the Animals Scientific Procedures Act UK 1986, under Home Office project licenses 70/8093 and 70/8867. Reversible unilateral ureteric obstruction model (R-UUO)The R-UUO model was performed as previously described (33). Briefly, 8 week old male C57BL/6JOlaHsd mice (Enviago) underwent laparotomy and the left ureter was isolated and the distal portion was ligated twice with 6/O black braided silk suture close to the bladder. In

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“…It is the consensus that the optimal management of CKD includes cardiovascular risk reduction, treatment of albuminuria, avoidance of potential nephrotoxins, and adjustments to drug dosing [11]. However, factors like socioeconomic, environmental, and behavioral factors have been believed to be important in management of CKD, but have not yet been delineated.…”

Section: Introductionmentioning

confidence: 99%

Associations of Waist Circumference, Socioeconomic, Environmental, and Behavioral Factors with Chronic Kidney Disease in Normal Weight, Overweight, and Obese People

Duong

Yang

et al. 2019

IJERPH

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Background: Chronic kidney disease (CKD) places a heavy burden on the healthcare system worldwide. The risk factors may vary by body adiposity. We aimed to investigate the associations of socioeconomic, environmental, and behavioral factors with CKD in different groups of body mass indexes (BMI). Methods: A case-control study was conducted in 3280 participants (1048 CKD and 2232 non-CKD) from seven hospitals and nearby communities from May 2012 to August 2015. Personal characteristics, anthropometrics, environmental exposures, and health−related behaviors were assessed using a structured questionnaire. The logistic regression models were utilized for analysis. Results: Older age (odd ratio, OR = 2.85; p < 0.001), being men (OR = 4.23; p < 0.001), smoking (OR = 3.36; p < 0.001), stable income (OR = 0.33; p < 0.001), higher education (OR = 0.37~0.38; p < 0.001), and daily adequate water intake (OR = 0.64; p = 0.010) were associated with CKD in normal weight people. Older age (OR = 2.49; p < 0.001), being men (OR = 3.36; p < 0.001), education (OR = 0.44, p = 0.004), hypertension (OR = 2.93; p < 0.001), diabetes (OR = 1.83; p = 0.004), and using traditional Chinese medicine (OR = 2.03, p = 0.014) were associated with CKD in overweight people. Older age (OR = 2.71; p < 0.001), being men (OR = 2.69; p < 0.001), hypertension (OR = 2.93; p < 0.001), diabetes (OR = 1.94; p = 0.001) were associated with CKD in obese people. Conclusions: The associated factors of CKD varied by different groups of BMI. These findings may help to develop potential interventions to manage CKD.Participants recruited were Taiwanese citizens aged 18 years or older, who understand Mandarin Chinese. We excluded participants who were diagnosed as CKD stage 5 or end-stage renal disease (ESRD), or who lacked renal function parameters. Cases were patients with chronic kidney disease stage 1 to stage 4. Controls were non-CKD patients, relatives of CKD patients, healthy people who underwent annual health checks, and in the communities around the selected hospitals. The final sample for analysis was 3280 participants with N = 1048 cases, and N = 2232 controls (Figure 1).

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Chronic Kidney Disease Diagnosis and Management

Cited by 1,051 publications

References 117 publications

Trauma exposure and stress‐related disorders in African‐American women with diabetes mellitus

Trauma exposure and stress‐related disorders in African‐American women with diabetes mellitus

Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease

Associations of Waist Circumference, Socioeconomic, Environmental, and Behavioral Factors with Chronic Kidney Disease in Normal Weight, Overweight, and Obese People

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