Chronic kidney disease burden among African migrants in three European countries and in urban and rural Ghana: the RODAM cross-sectional study

Adjei, David Nana; Stronks, Karien; Adu, Dwomoa; Beune, Erik; Meeks, Karlijn; Smeeth, Liam; Addo, Juliet; Owuso-Dabo, Ellis; Klipstein‐Grobusch, Kerstin; Mockenhaupt, Frank P.; Schulze, Matthias B.; Spranger, Joachim; Bahendeka, Silver; Aikins, Ama de‐Graft; Agyemang, Charles

doi:10.1093/ndt/gfx347

Cited by 32 publications

(50 citation statements)

References 37 publications

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“…This observation corroborates with our hypothesis that differences in sUA levels would be a cumulative result of dietary patterns, BMI, kidney function and use of certain medications. Previous studies have shown that total energy intake, obesity and use of medications were higher in migrants than non‐migrants, while chronic kidney disease and high physical activity levels were more prevalent in rural residents than urban residents and migrants . In our study, we similarly observed higher levels of total energy intake, obesity and use of certain medications in migrants, while reduced eGFR and physical activity were highly prevalent in rural residents.…”

Section: Discussionsupporting

confidence: 83%

“…For example, international migrants and urban residents have been shown to have increased consumption of purine‐rich food, along with increased levels of overweight/obesity . In addition, migrants have higher rates of hypertension and access to treatment than non‐migrants . Considering these differences in rural, urban and migrant SSA populations, we hypothesised that sUA levels and their associations with CVD risk would vary among SSA populations.…”

Section: Introductionmentioning

confidence: 99%

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Hyperuricaemia and its association with 10‐year risk of cardiovascular disease among migrant and non‐migrant African populations: the RODAM study

Chilunga

Henneman

Requena‐Méndez

et al. 2020

Tropical Med Int Health

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objective In the advent of rapid urbanisation, migration and epidemiological transition, the extent to which serum uric acid (sUA) affects cardiovascular disease (CVD) risk among Africans is not well understood. We assessed differences in sUA levels and associations with CVD risk among migrant Ghanaians in Europe and non-migrant Ghanaians in rural and urban Ghana.methods Baseline data from 633 rural, 916 urban and 2315 migrant participants (40-70 years) from the cross-sectional RODAM study were analysed. Hyperuricaemia was defined as sUA >7 mg/dl in men and >6 mg/dl in women. The 10-year risk of atherosclerotic cardiovascular disease (ASCVD) was calculated using the American College of Cardiology (ACC)/American Heart Association (AHA) risk score which takes into account ethnic minority populations. High CVD risk was defined as ASCVD risk scores ≥7.5%. Logistic regressions were used to assess associations between hyperuricaemia and CVD risk.results Prevalence for hyperuricaemia in rural, urban and migrant participants was 17.4%, 19.1% and 31.7% for men, and 15.9%, 18.2% and 33.2% for women, respectively. Hyperuricaemia was positively associated with elevated CVD risk among rural residents (adjusted OR for men 3.28, 95% CI: 1.21-8.96, 6.36, 95% CI: 2.98-13.56 for women), urban residents (1.12, 95% CI: 0.45-2.81 for men, 2.11, 95% CI: 1.26-3.52 for women) and migrants (1.73, 95% CI: 1.01-2.96 for men, 4.61, 95% CI: 3.05-6.97 for women).conclusion Our study shows variations of sUA levels in different African contexts. Hyperuricaemia is associated with elevated 10-year CVD risk in both migrants and non-migrants. Further studies should identify factors driving associations between sUA and CVD risk in Africans.keywords serum uric acid, cardiovascular disease risk, sub-Saharan Africans, migrants, Europe, RODAM study Sustainable Development Goals (SDGs): SDG 3 (good health and well-being), SDG 10 (reduced inequalities), SDG 17 (partnerships for the goals)

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Hyperuricaemia and its association with 10‐year risk of cardiovascular disease among migrant and non‐migrant African populations: the RODAM study

Chilunga

Henneman

Requena‐Méndez

et al. 2020

Tropical Med Int Health

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“…CKD has now emerged as a significant public health challenge in sub‐Saharan Africa with a reported prevalence of 13.9% in a meta‐analysis . The prevalence of CKD in Ghana has been shown to be 13.3% in a recent study . As a non‐communicable disease, CKD has not received the necessary attention in most countries in sub‐Saharan Africa including Ghana .…”

Section: Introductionmentioning

confidence: 99%

“…6 The prevalence of CKD in Ghana has been shown to be 13.3% in a recent study. 7 As a noncommunicable disease, CKD has not received the necessary attention in most countries in sub-Saharan Africa including Ghana. 8 CKD is associated with increasing morbidity and mortality and also known to impact negatively on quality of life.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and predictors of chronic kidney disease among Ghanaian patients with hypertension and diabetes mellitus: A multicenter cross‐sectional study

Tannor

Sarfo

Mobula

et al. 2019

J of Clinical Hypertension

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The burden of chronic kidney disease (CKD) is rapidly rising in developing countries due to astronomical increases in key risk factors including hypertension and diabetes. We sought to assess the burden and predictors of CKD among Ghanaians with hypertension and/or diabetes mellitus in a multicenter hospital‐based study. We conducted a cross‐sectional study in the Ghana Access and Affordability Program (GAAP) involving adults with hypertension only (HPT), hypertension with diabetes mellitus (HPT + DM), and diabetes mellitus only (DM) in 5 health facilities in Ghana. A structured questionnaire was administered to collect data on demographic variables, medical history, and clinical examination. Serum creatinine and proteinuria were measured, and estimated glomerular filtration rate derived using the CKD‐EPI formula. A multivariable logistic regression model was used to identify factors associated with CKD. A total of 2781 (84.4%) of 3294 participants had serum creatinine and proteinuria data available for analysis. The prevalence of CKD was 242 (28.5%) among participants with both DM and HPT, 417 (26.3%) among participants with HPT, and 56 (16.1%) among those with DM alone. Predictors of CKD were increasing age aOR 1.26 (1.17‐1.36), low educational level aOR 1.7 (1.23‐2.35), duration of HPT OR, 1.02 (1.01‐1.04), and use of herbal medications aOR 1.39 (1.10‐1.75). Female gender was protective of CKD aOR 0.75 (0.62‐0.92). Among patients with DM, increasing age and systolic blood pressure were associated with CKD. There is high prevalence of CKD among DM and hypertension patients in Ghana. Optimizing blood pressure control and limiting the use of herbal preparations may mitigate CKD occurrence in high cardiovascular risk populations in developing countries.

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“…The prevalence of CKD is estimated to be between 10 and 13% globally [6,7] and 13.9% in sub-Saharan Africa [8]. In Ghana, CKD has been estimated to be 13.3% [9], however, very little is known about its prevalence among homeless people in Ghana, due to lack of surveillance systems for monitoring the health needs of the poor and homeless and hence insu cient data on risk factors for end stage renal disease (ESRD) [10]. We therefore carried out a survey of the prevalence of CKD among homeless and slum dwellers in two suburbs (Agbogbloshie and Nima) of Accra, Ghana, so as to provide base line information on the burden of this disease in this vulnerable group of our society.…”

Section: Introductionmentioning

confidence: 99%

Chronic Kidney Diseases Among Homeless and Slum Dwellers in Accra: A Survey Study

Bawah

Edufia

Yussif

et al. 2020

Preprint

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Objective: This study aimed at determining the prevalence of chronic kidney disease (CKD) among homeless people in Nima and Agbogbloshie, Accra, Ghana and to evaluate the association between socio‑demographic characteristics and CKD. Results: Participants with normal serum creatinine (SCr), made up of 232 males and 280 females totaling 512 took part in the study. Those with normal glomerular filtration rate (GFR) were 86% and 84.6% by means of the C-G and MDRD equations respectively. According to the C-G formula, kidney damage and mild to severe renal insufficiency was found in 13.2% of the participants and 4 participants (0.8%) had renal failure. On the other hand, 15.4% of the participants were found to have some kidney damage and mild to severe renal insufficiency according to the MDRD formula with no participant suffering from kidney failure. The prevalence of renal dysfunction among the homeless Ghanaians was significant especially among those with hypertension, diabetes and human immunodeficiency syndrome virus (HIV) infection. . Intensive social support aimed at preventing and managing kidney disease is crucial if we are to reduce the incidence of kidney related illnesses in homeless people.

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Chronic kidney disease burden among African migrants in three European countries and in urban and rural Ghana: the RODAM cross-sectional study

Cited by 32 publications

References 37 publications

Hyperuricaemia and its association with 10‐year risk of cardiovascular disease among migrant and non‐migrant African populations: the RODAM study

Hyperuricaemia and its association with 10‐year risk of cardiovascular disease among migrant and non‐migrant African populations: the RODAM study

Prevalence and predictors of chronic kidney disease among Ghanaian patients with hypertension and diabetes mellitus: A multicenter cross‐sectional study

Chronic Kidney Diseases Among Homeless and Slum Dwellers in Accra: A Survey Study

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