Chronic Kidney Disease After Simultaneous Liver‐Kidney Transplantation: Refining Patient Selection

Asrani, Sumeet K.

doi:10.1002/lt.26075

Liver Transpl

2021

DOI: 10.1002/lt.26075

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Chronic Kidney Disease After Simultaneous Liver‐Kidney Transplantation: Refining Patient Selection

Sumeet K. Asrani

Abstract: Sumeet K. Asrani and Mitra K. Nadim had access to all the study data, take responsibility for the accuracy of the analysis, and had authority over manuscript preparation and the decision to submit the manuscript for publication. Sumeet K. Asrani and Mitra K. Nadim approved the manuscript.

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“…(8)(9)(10)(11)(12)(13) Therefore, to better understand SLKT in the United States, we created the United States SLKT study (US-SLKT), a multicenter observational study structured to describe contemporary trends and inform the drivers of mortality among SLKT recipients. (15,16)…”

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Temporal Trends and Evolving Outcomes After Simultaneous Liver‐Kidney Transplantation: Results from the US SLKT Consortium

Cullaro

Sharma

et al. 2021

Liver Transpl.

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We aimed to understand the contemporary changes in the characteristics and the determinants of outcomes among simultaneous liver-kidney transplantation (SLKT) recipients at 6 liver transplantation centers in the United States. We retrospectively enrolled SLKT recipients between 2002 and 2017 in the US Multicenter SLKT Consortium. We analyzed time-related trends in recipient characteristics and outcomes with linear regression and nonparametric methods. Clustered Cox regression determined the factors associated with 1-year and overall survival. We enrolled 572 patients. We found significant changes in the clinical characteristics of SLKT recipients: as compared with 2002, recipients in 2017 were older (59 versus 52 years; P < 0.001) and more likely to have chronic kidney disease (71% versus 33%; P < 0.001). There was a marked improvement in 1-year survival during the study period: 89% in 2002 versus 96% in 2017 (P < 0.001). We found that the drivers of 1-year mortality were SLKT year, hemodialysis at listing, donor distance, and delayed kidney allograft function. The drivers of overall mortality were an indication of acute kidney dysfunction, body mass index, hypertension, creatinine at SLKT, ventilation at SLKT, and donor quality. In this contemporary cohort of SLKT recipients, we highlight changes in the clinical characteristics of recipients. Further, we identify the determinants of 1-year and overall survival to highlight the variables that require the greatest attention to optimize outcomes.

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confidence: 99%

Temporal Trends and Evolving Outcomes After Simultaneous Liver‐Kidney Transplantation: Results from the US SLKT Consortium

Cullaro

Sharma

et al. 2021

Liver Transpl.

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Chronic Kidney Disease After Simultaneous Liver‐Kidney Transplantation: Refining Patient Selection

Abstract: Sumeet K. Asrani and Mitra K. Nadim had access to all the study data, take responsibility for the accuracy of the analysis, and had authority over manuscript preparation and the decision to submit the manuscript for publication. Sumeet K. Asrani and Mitra K. Nadim approved the manuscript.

Cited by 1 publication

References 8 publications

Temporal Trends and Evolving Outcomes After Simultaneous Liver‐Kidney Transplantation: Results from the US SLKT Consortium

Temporal Trends and Evolving Outcomes After Simultaneous Liver‐Kidney Transplantation: Results from the US SLKT Consortium

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