Chronic kidney disease after lung transplantation in a changing era

Grootjans, Heleen; Verschuuren, Erik; Gemert, Johanna P. van; Kerstjens, Huib A.M.; Bakker, Stephan J. L.; Berger, Stefan P.; Gan, C. Tji-Joong

doi:10.1016/j.trre.2022.100727

Cited by 6 publications

(1 citation statement)

References 105 publications

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“…Chronic kidney disease (CKD) is a progressive and irreversible disease that happens after the decline of renal functions to a specific threshold [52]. Progressive tubulointerstitial fibrosis is a common characteristic of CKD leading to end-stage renal disease (ESRD) [53].…”

Section: Published Clinical Studies Using Msc-exos Therapy Msc-exos F...mentioning

confidence: 99%

Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials

2023

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Mesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their robust immunomodulatory and regenerative properties. Their paracrine activity is one of the most important features that contribute to their efficacy. Recently, it has been demonstrated that the production of various factors via extracellular vesicles, especially exosomes, governs the principal efficacy of MSCs after infusion in experimental models. Compared to MSCs themselves, MSC-derived exosomes (MSC-Exos) have provided significant advantages by efficiently decreasing unfavorable adverse effects, such as infusion-related toxicities. MSC-Exos is becoming a promising cell-free therapeutic tool and an increasing number of clinical studies started to assess the therapeutic effect of MSC-Exos in different diseases. In this review, we summarized the ongoing and completed clinical studies using MSC-Exos for immunomodulation, regenerative medicine, gene delivery, and beyond. Additionally, we summarized MSC-Exos production methods utilized in these studies with an emphasis on MSCs source, MSC-Exos isolation methods, characterization, dosage, and route of administration. Lastly, we discussed the current challenges and future directions of exosome utilization in different clinical studies as a novel therapeutic strategy.

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Section: Published Clinical Studies Using Msc-exos Therapy Msc-exos F...mentioning

confidence: 99%