Chronic Jet Lag Exacerbates Jejunal and Colonic Microenvironment in Mice

Li, Qing; Wang, Bo; Qiu, Hong-Yi; Yan, Xiu-Juan; Cheng, Li; Wang, Qianqian; Chen, Shengliang

doi:10.3389/fcimb.2021.648175

Cited by 6 publications

(6 citation statements)

References 37 publications

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“…Previous reports have emphasized the significance of tryptophan metabolites in regulating the interactions between circadian rhythms, GM, and immune functions. For instance, circadian disorders, such as chronic jet lag, have been linked to gut dysbiosis characterized by an increased Firmicutes‐to‐Bacteroidetes ratio and reduced levels of tryptophan and its derivatives 101 . Circadian rhythm disruption can also lead to the loss of rhythmicity in intestinal Lactobacillus and circulating tryptophan metabolites, contributing to inflammatory diseases and dysregulation of gut integrity 102 .…”

Section: Discussionmentioning

confidence: 99%

“…For instance, circadian disorders, such as chronic jet lag, have been linked to gut dysbiosis characterized by an increased Firmicutes-to-Bacteroidetes ratio and reduced levels of tryptophan and its derivatives. 101 Circadian rhythm disruption can also lead to the loss of rhythmicity in intestinal Lactobacillus and circulating tryptophan metabolites, contributing to inflammatory diseases and dysregulation of gut integrity. 102 Another study demonstrated that circadian rhythm disturbance induced by LD cycle shifts could trigger visceral hypersensitivity resembling the pathophysiology of irritable bowel syndrome, mediated by GM alterations such as Firmicutes and Proteobacteria, as well as their metabolites like tryptophan and steroid hormones.…”

Section: The Homeostatic Crosstalk In Gm-liver-brain Axis In Response...mentioning

confidence: 99%

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Homeostatic crosstalk among gut microbiome, hypothalamic and hepatic circadian clock oscillations, immunity and metabolism in response to different light–dark cycles: A multiomics study

Zhen,

Wang,

et al. 2023

Journal of Pineal Research

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The accelerated pace of life at present time has resulted in tremendous alterations in living patterns. Changes in diet and eating patterns, in particular, coupled with irregular light–dark (LD) cycles will further induce circadian misalignment and lead to disease. Emerging data has highlighted the regulatory effects of diet and eating patterns on the host‐microbe interactions with the circadian clock (CC), immunity, and metabolism. Herein, we studied how LD cycles regulate the homeostatic crosstalk among the gut microbiome (GM), hypothalamic and hepatic CC oscillations, and immunity and metabolism using multiomics approaches. Our data demonstrated that central CC oscillations lost rhythmicity under irregular LD cycles, but LD cycles had minimal effects on diurnal expression of peripheral CC genes in the liver including Bmal1. We further demonstrated that the GM could regulate hepatic circadian rhythms under irregular LD cycles, the candidate bacteria including Limosilactobacillus, Actinomyces, Veillonella, Prevotella, Campylobacter, Faecalibacterium, Kingella, and Clostridia vadinBB60 et al. A comparative transcriptomic study of innate immune genes indicated that different LD cycles had varying effects on immune functions, while irregular LD cycles had greater impacts on hepatic innate immune functions than those in the hypothalamus. Extreme LD cycle alterations (LD0/24 and LD24/0) had worse impacts than slight alterations (LD8/16 and LD16/8), and led to gut dysbiosis in mice receiving antibiotics. Metabolome data also demonstrated that hepatic tryptophan metabolism mediated the homeostatic crosstalk among GM‐liver–brain axis in response to different LD cycles. These research findings highlighted that GM could regulate immune and metabolic disorders induced by circadian dysregulation. Further, the data provided potential targets for developing probiotics for individuals with circadian disruption such as shift workers.

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Section: Discussionmentioning

confidence: 99%

Section: The Homeostatic Crosstalk In Gm-liver-brain Axis In Response...mentioning

confidence: 99%

Homeostatic crosstalk among gut microbiome, hypothalamic and hepatic circadian clock oscillations, immunity and metabolism in response to different light–dark cycles: A multiomics study

Zhen,

Wang,

et al. 2023

Journal of Pineal Research

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“…Sleep duration reduction can significantly decrease GBM diversity (183,184). Additionally, exposure to SJL exacerbated GBM and metabolite homeostasis in the jejunum and colon of mice and was also detected in humans (181,185).…”

Section: Microbiome Dysbiosismentioning

confidence: 99%

Sleep and circadian rhythm disturbance in kidney stone disease: a narrative review

He,

Wang,

et al. 2023

Front. Endocrinol.

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The circadian rhythm generated by circadian clock genes functions as an internal timing system. Since the circadian rhythm controls abundant physiological processes, the circadian rhythm evolved in organisms is salient for adaptation to environmental change. A disturbed circadian rhythm is a trigger for numerous pathological events. Recently, accumulated data have indicated that kidney stone disease (KSD) is related to circadian rhythm disturbance. However, the mechanism between them has not been fully elucidated. In this narrative review, we summarized existing evidence to illustrate the possible association between circadian rhythm disturbance and KSD based on the epidemiological studies and risk factors that are linked to circadian rhythm disturbance and discuss some chronotherapies for KSD. In summary, KSD is associated with systemic disorders. Metabolic syndrome, inflammatory bowel disease, and microbiome dysbiosis are the major risk factors supported by sufficient data to cause KSD in patients with circadian rhythm disturbance, while others including hypertension, vitamin D deficiency, parathyroid gland dysfunction, and renal tubular damage/dysfunction need further investigation. Then, some chronotherapies for KSD were confirmed to be effective, but the molecular mechanism is still unclear.

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“…Several studies indicate that a robust interconnection between the gut microbiota and the host's circadian clock exists. For example, both human and mouse models exhibit daily rhythmicity in gut microbiota composition and metabolite levels, which can be perturbed by genetic or environmental disruptions of the circadian clock [13][14][15][16][17] . On the other hand, the gut microbiota was shown to play a fundamental role in regulating host's circadian transcriptional profiles in the gut and liver, thereby modulating the circadian regulation of host metabolism 14,[18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

A functional circadian clock regulates composition and daily bacterial load of the gut microbiome inDrosophila melanogaster

Battistolli,

Varponi,

Romoli

et al. 2024

Preprint

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While Drosophila melanogaster serves as a crucial model for investigating both the circadian clock and gut microbiome, our understanding of their relationship in this organism is still limited. Recent analyses suggested that the Drosophila gut microbiome modulates the host circadian transcriptome to minimize rapid oscillations in response to changing environments. To delve deeper into the potential relationship between the gut microbiota and circadian clock in Drosophila, we examined the composition and abundance of the gut microbiota in wild-type and arrhythmic per01 flies, under 12 h:12 h light: dark (12:12 LD) and constant darkness (DD) conditions. The gut microbiota of wild-type and per01 flies showed differences in composition, suggesting that the D. melanogaster circadian clock has a role in shaping the gut microbiome. In 12:12 LD and DD conditions, per01 mutants showed significant daily variations in gut bacterial quantity, unlike wild-type flies. This suggests that the circadian clock in D. melanogaster plays a role in maintaining daily stability in gut microbiome load. Finally, some gut bacteria exhibited significant 24 h fluctuations in their relative abundance, which appeared independent from the fly circadian clock, suggesting that certain gut commensal bacteria in Drosophila may possess a host-independent circadian clock.

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Chronic Jet Lag Exacerbates Jejunal and Colonic Microenvironment in Mice

Cited by 6 publications

References 37 publications

Homeostatic crosstalk among gut microbiome, hypothalamic and hepatic circadian clock oscillations, immunity and metabolism in response to different light–dark cycles: A multiomics study

Homeostatic crosstalk among gut microbiome, hypothalamic and hepatic circadian clock oscillations, immunity and metabolism in response to different light–dark cycles: A multiomics study

Sleep and circadian rhythm disturbance in kidney stone disease: a narrative review

A functional circadian clock regulates composition and daily bacterial load of the gut microbiome inDrosophila melanogaster

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