Chronic itch impairs mood and HPA axis function in mice: modulation by CRFR1 antagonist

Zhao, Xin; Chao, Yu–Faye; Ye, Feng; Yan-gui, Wang; Mei, Qiyong; Ma, Qing; Cui, Wugeng; Zhou, Wenhua

doi:10.1097/j.pain.0000000000001319

Cited by 13 publications

(9 citation statements)

References 31 publications

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“…This was confirmed also by other single center studies (Stumpf et al, 2018). A speculative reason for this correlation is that itch correlates with skin inflammation and skin inflammation induces the serotonin network in the brain, leading to depression and anxiety (Yosipovitch et al, 2008;Zhao et al, 2018).…”

Section: Discussionsupporting

confidence: 70%

Itch and Mental Health in Dermatological Patients across Europe: A Cross-Sectional Study in 13 Countries

Dalgard

Svensson

Halvorsen

et al. 2020

Journal of Investigative Dermatology

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Itch is a highly prevalent and multidimensional symptom. We aimed to analyze the association between itch and mental health in dermatological patients. This multicenter study is observational and cross-sectional and was conducted in dermatological clinics across 13 European countries. A total of 3,530 patients and 1,094 healthy controls were included. Patients were examined clinically. Outcome measures were itch (presence, chronicity, and intensity), the Hospital Anxiety and Depression Scale, EQ-5D visual analogue scale, sociodemographics, suicidal ideation, and stress (negative life events and economic difficulties). Ethical approval was obtained. Results showed significant association between the presence of itch in patients and clinical depression (odds ratio, 1.53; 95% confidence interval, 1.15e2.02), suicidal ideation (odds ratio, 1.27; 95% confidence interval, 1.01e1.60), and economic difficulties (odds ratio, 1.24; 95% confidence interval, 1.10e1.50). The mean score of reported generic health status assessed by the EQ-5D visual analogue scale was 65.9 (standard deviation ¼ 20.1) in patients with itch, compared with 74.7 (standard deviation ¼ 18.0) in patients without itch (P < 0.001) and 74.9 (standard deviation ¼ 15.7) in controls with itch compared with 82.9 (standard deviation ¼ 15.6) in controls without itch (P < 0.001). Itch contributes substantially to the psychological disease burden in dermatological patients, and the management of patients should include access to multidisciplinary care.

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Section: Discussionsupporting

confidence: 70%

Itch and Mental Health in Dermatological Patients across Europe: A Cross-Sectional Study in 13 Countries

Dalgard

Svensson

Halvorsen

et al. 2020

Journal of Investigative Dermatology

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“…The psychological burden produced by chronic itch was reported with high incidences of suicidal motivation (21.1%) and psychiatric illnesses (70%) ( 93 ). Zhao et al ( 94 ) reported that AEW mice developed anxiety-like symptoms 2–3 weeks and depression-like phenotypes 3–4 weeks after AEW treatment, suggesting that mood impairment due to chronic itch evolves over time. The mood impairment behaviours were significantly related to the itch-associated behaviour.…”

Section: Itch Of Dry Skin and Anxietymentioning

confidence: 99%

Mechanisms and Management of Itch in Dry Skin

Moniaga¹,

Tominaga²,

Takamori³

2020

Acta Derm Venerol

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Itch is an unpleasant sensation that may disturb quality of life, and for which the pathomechanism and appropriate treatments are unclear. Chronic itch, which lasts more than 6 weeks, often accompanies pathological dry skin-based conditions, such as xerosis, atopic dermatitis, liver and kidney diseases. A decline in skin barrier function is thought to be the primary cause of itch induced by dry skin. Many kinds of mediators, receptors, and channels are involved in itch signalling among the skin nervous system, skin cells, and central nervous system. Several therapeutic options for itching have thus been developed, such as phototherapy, phospholipids, antioxidants, and emollients. Chronic itch is a burdensome clinical problem that often accompanies pathological dry skin-based conditions, such as atopic dermatitis, and systemic disorders, such as kidney diseases, with an unclear pathomechanism and treatments. One of the basic mouse models to investigate mechanisms of itch associated with dry skin is a mixture of acetone and ether followed by water. Animal studies using the acetone and ether followed by water model have revealed that many mediators and receptors, e.g. mas-related G protein-coupled receptor family, transient receptor potential, and chemokines, are responsible for itch and its hypersensitivity, supporting the hypothesis that dry skin-induced itch is a histamine-independent pathway. New insights have been acquired into the interplay between neurones and non-neuronal cells in the initiation, modulation, and sensitization of itch. Several thera peutic options for itching have thus been developed. This review summarizes the updated pathogenesis and therapeutic strategies for itch in dry skin conditions.

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“…Other studies have confirmed this ( 36 ). One presumed reason for this correlation is that itching is associated with skin inflammation, which induces serotonin networks in the brain, leading to depression and anxiety ( 37 , 38 ). Therefore, the symptoms of itching can be used as a major cause of mediating the occurrence of anxiety and depression in patients with CSU.…”

Section: Discussionmentioning

confidence: 99%

Association of Chronic Spontaneous Urticaria With Anxiety and Depression in Adolescents: A Mediation Analysis

et al. 2021

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Background: Chronic spontaneous urticaria (CSU) is related to psychiatric comorbidities. It is not clear whether the relationship is affected by modifiable factors.Objectives: To investigate whether the effect of CSU on anxiety and depression in adolescents is mediated by the symptoms of itching and sleep disturbance.Methods: Questionnaire survey was conducted among newly enrolled college students. Dermatologists diagnose skin diseases, including CSU, during health examination. Anxiety and depression were measured by the Generalized Anxiety Disorder Scale and Patient Health Questionnaire, respectively. Sleep quality was measured by the Pittsburgh Sleep Quality Index. The symptoms of itching were measured by the numeric rating scale. According to the hypothesis, the mediating effect model was put forward and the structural equation model is used to build the mediation effect model. The mediation effect model was proposed according to the hypothesis and established using a structural equation model.Results: A total of 2,358 students with no history of systemic disease and no pruritus disease (except CSU) were included in the analysis. A total of 393 CSU patients were included, and 1,965 healthy controls were selected based on age and sex matching. CSU was significantly associated with both anxiety and depression when the symptoms of itching and sleep quality were not modeled. A mediation model was proposed as CSU → itching → sleep disturbance → anxiety or depression. Itching and sleep quality mediated 65.4 and 77.6% of CSU's effects on anxiety and depression, respectively, and CSU had no significant direct effect on anxiety or depression in the mediation models.Conclusions: The associations of CSU with anxiety and depression were mediated by the symptoms of itching and sleep disturbance. Effectively reducing the symptoms of itching thereby could increase natural sleep, which can further treat the emotional disorders among patients with CSU.

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Chronic itch impairs mood and HPA axis function in mice: modulation by CRFR1 antagonist

Cited by 13 publications

References 31 publications

Itch and Mental Health in Dermatological Patients across Europe: A Cross-Sectional Study in 13 Countries

Itch and Mental Health in Dermatological Patients across Europe: A Cross-Sectional Study in 13 Countries

Mechanisms and Management of Itch in Dry Skin

Association of Chronic Spontaneous Urticaria With Anxiety and Depression in Adolescents: A Mediation Analysis

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