Chronic intestinal pseudo-obstruction

Cogliandro, Rosanna; Giorgio, Roberto De; Barbara, Giovanni; Cogliandro, L.; Concordia, Alessandra; Corinaldesi, Roberto; Stanghellini, Vincenzo

doi:10.1016/j.bpg.2007.03.002

Cited by 41 publications

(54 citation statements)

References 57 publications

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“…After the failure of a targeted motility approach, we considered the autoimmune disease as the core of the problem and the patient was successfully given a steroid therapy. SLE-related CIP, generally unusual, is reported as a complication of an active disease and favourably responds to high doses of corticosteroids [6] . In our case, CIP was the only clinical demonstration of the SLE.…”

Section: Discussionmentioning

confidence: 99%

Intestinal pseudo-obstruction in inactive systemic lupus erythematosus: An unusual finding

Leonardi

Bortoli²,

Bellini³

et al. 2010

WJGPT

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Chronic intestinal pseudo-obstruction (CIP) is an infrequent complication of an active systemic lupus erythematosus (SLE). We illustrate a case of SLE inactive-related CIP. A 51-year old female with inactive SLE (ECLAM score 2) was hospitalized with postprandial fullness, vomiting, abdominal bloating and abdominal pain. She had had no bowel movements for five days. Plain abdominal X-ray revealed multiple fluid levels and dilated small and large bowel loops with air-fluid levels. Intestinal contrast radiology detected dilated loops. CIP was diagnosed. The patient was treated with prokinetics, octreotide, claritromycin, rifaximin, azathioprine and tegaserod without any clinical improvement. Then methylprednisolone (500 mg iv daily) was started. After the first administration, the patient showed peristaltic movements. A bowel movement was reported after the second administration. A plain abdominal X-ray revealed no air-fluid levels. Steroid therapy was slowly reduced with complete resolution of the symptoms. The patient is still in a good clinical condition. SLE-related CIP is generally reported as a complication of an active disease. In our case, CIP was the only clinical demonstration of the SLE.

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Section: Discussionmentioning

confidence: 99%

Intestinal pseudo-obstruction in inactive systemic lupus erythematosus: An unusual finding

Leonardi

Bortoli²,

Bellini³

et al. 2010

WJGPT

View full text Add to dashboard Cite

show abstract

“…Small bowel manometry is invariably abnormal in CIPO patients [2,3,45] ; however, the test is not of diagnostic value due to its low specificity. At best, it can play a supportive role in defining the diagnosis, since it can contribute to differentiate mechanical from functional obstruction and to recognize the underlying pathophysiological mechanism [2,3,45] .…”

Section: Manometrymentioning

confidence: 99%

“…At best, it can play a supportive role in defining the diagnosis, since it can contribute to differentiate mechanical from functional obstruction and to recognize the underlying pathophysiological mechanism [2,3,45] .…”

Section: Manometrymentioning

confidence: 99%

“…They can be summarized as follows: uncoordinated bursts of powerful contractions with variable duration are suggestive of an underlying intrinsic neuropathy [1][2][3][4][45][46][47][48] conversely, normally coordinated motor patterns with low amplitude have been reported in patients with a myogenic disorder [1][2][3][4][45][46][47][48] . Nonetheless, low amplitude contractions may merely reflect the inability of the manometric technique to record non-occlusive contractions, such as in the case of dilated bowel loops [1][2][3][4][45][46][47][48] .…”

Section: Manometrymentioning

confidence: 99%

“…Unlike what is observed in pseudo-obstruction, the manometric pattern of mechanical occlusion is characterized by giant contractions (prolonged contractions lasting at least 10 s and can be either propagated or non propagated) or clustered contractions (3-10 regular contractions, occurring 1 per 5 s preceded and followed by ≥ 1 min of absent motor activity lasting at least 20 min and can be either propagated or non propagated) [1][2][3][4][45][46][47][48][49] .…”

Section: Manometrymentioning

confidence: 99%

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