Chronic intestinal pseudo-obstruction in patients with systemic lupus erythematosus: report of four cases

Ceccato, Federico; Salas, Adrián; Gongora, Vanina; Ruta, Santiago; Roverano, Susana; Marcos, Juan Carlos; García, Mercedes; Paira, Sergio

doi:10.1007/s10067-007-0760-5

Cited by 43 publications

(34 citation statements)

References 12 publications

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“…Until now, only 27 cases of SLE related CIP have been reported in literature [2] . This is the only SLE-related case of CIP in our experience.…”

Section: Discussionmentioning

confidence: 99%

“…Chronic intestinal pseudo-obstruction (CIP) is a complication that usually occurs during active SLE and is characterised by ineffective intestinal propulsion without any mechanical obstruction of the gut [2] . It is caused by the involvement of visceral smooth muscle and enteric nervous system and can be further classified as idiopathic or secondary.…”

Section: Introductionmentioning

confidence: 99%

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Intestinal pseudo-obstruction in inactive systemic lupus erythematosus: An unusual finding

Leonardi

Bortoli²,

Bellini³

et al. 2010

WJGPT

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Chronic intestinal pseudo-obstruction (CIP) is an infrequent complication of an active systemic lupus erythematosus (SLE). We illustrate a case of SLE inactive-related CIP. A 51-year old female with inactive SLE (ECLAM score 2) was hospitalized with postprandial fullness, vomiting, abdominal bloating and abdominal pain. She had had no bowel movements for five days. Plain abdominal X-ray revealed multiple fluid levels and dilated small and large bowel loops with air-fluid levels. Intestinal contrast radiology detected dilated loops. CIP was diagnosed. The patient was treated with prokinetics, octreotide, claritromycin, rifaximin, azathioprine and tegaserod without any clinical improvement. Then methylprednisolone (500 mg iv daily) was started. After the first administration, the patient showed peristaltic movements. A bowel movement was reported after the second administration. A plain abdominal X-ray revealed no air-fluid levels. Steroid therapy was slowly reduced with complete resolution of the symptoms. The patient is still in a good clinical condition. SLE-related CIP is generally reported as a complication of an active disease. In our case, CIP was the only clinical demonstration of the SLE.

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“…Until now, only 27 cases of SLE related CIP have been reported in literature [2] . This is the only SLE-related case of CIP in our experience.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intestinal pseudo-obstruction in inactive systemic lupus erythematosus: An unusual finding

Leonardi

Bortoli²,

Bellini³

et al. 2010

WJGPT

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“…5 No specific autoantibodies have been found; however, a few case reports have noted the high prevalence of anti-SSB antibodies in patients with CIPO secondary to SLE. 4,5,9 Our patient had CIPO with haematological involvement as described above, in addition to positive anti-SSB antibodies.…”

Section: Discussionmentioning

confidence: 78%

Chronic intestinal pseudo-obstruction: a rare first manifestation of systemic lupus erythematosus

Khairullah

Raja

Yahya

et al. 2013

Lupus

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Chronic intestinal pseudo-obstruction (CIPO) is a rare clinical syndrome of ineffective intestinal motility characterised by clinical and radiological evidence of intestinal obstruction with no identifiable mechanical lesion. CIPO can either be idiopathic or secondary to a systemic disease, like systemic lupus erythematosus (SLE). Fewer than 30 cases of CIPO secondary to SLE have been reported so far. Here we describe a case of SLE with the initial presentation of CIPO. In SLE-related CIPO, treatment includes a combination of high-dose intravenous corticosteroids, immunosuppressants and supportive care. With awareness of this condition, unnecessary surgical intervention and repeated invasive procedures could be avoided. Early initiation of treatment would avoid complications and bring about resolution of symptoms.

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“…Also some reports suggest a female preponderance with a mean age of presentation of 40 6. It usually occurs in patients with active SLE but may also be the initial presentation 7. The pathogenesis is not known and is believed to be caused by deposition of immune complex in smooth muscle, enteric nervous system dysfunction or vasculitis, with or without ureteral and vesical involvement 8…”

Section: Discussionmentioning

confidence: 99%

Lupus causing small bowel obstruction

et al. 2018

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A 20-year-old female patient was admitted to hospital in 2015 with 1 year history of recurrent abdominal pain, distension, borborygmi and nausea. The patient had a background of systemic lupus erythematous (SLE) diagnosed 4 years before, with skin, joint and renal involvement. The initial investigations have shown a long segment of ileal inflammation with upstream obstruction. Differential diagnoses were mainly SLE enteritis or concomitant Crohn’s. Patient failed the initial conservative management and had a laparotomy with small bowel (SB) resection and ileostomy. The histology was suggestive of autoimmune enteritis. Although bowel involvement is a frequent feature of SLE, surgery for obstruction is extremely rare. Postoperatively, she had an emergency admission and was diagnosed with SB volvulus with perforation. She underwent further resection and stoma refashioning in 2016. As a consequence, she developed short gut syndrome. Eventually, the stoma was reversed and parenteral nutrition was stopped and weight became stable.

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Chronic intestinal pseudo-obstruction in patients with systemic lupus erythematosus: report of four cases

Cited by 43 publications

References 12 publications

Intestinal pseudo-obstruction in inactive systemic lupus erythematosus: An unusual finding

Intestinal pseudo-obstruction in inactive systemic lupus erythematosus: An unusual finding

Chronic intestinal pseudo-obstruction: a rare first manifestation of systemic lupus erythematosus

Lupus causing small bowel obstruction

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