Chronic interstitial lung disease in children

Fan, Leland L.; Langston, Claire

doi:10.1002/ppul.1950160309

Cited by 119 publications

(74 citation statements)

References 119 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…So far no association with EBV infection has been documented [2,22,23]. The chronic ILD observed in the current patients obviously did not progress into clearcut CFA.…”

Section: Discussionmentioning

confidence: 44%

“…Furthermore, some forms of chronic ILD of unknown aetiology might have their origin in earlier, clinically unrecognized viral infections [1,2]. A prospective study, performed to evaluate the diagnostic value of BAL in 29 immunocompetent children with chronic diffuse pulmonary infiltrates, identified two adenovirus and one CMV infection [12].…”

Section: Discussionmentioning

confidence: 99%

“…Two recent studies have described four out of 48 children who had ILD as the result of an infection (adenovirus, Mycoplasma pneumoniae, influenza B virus), and one other male who had positive results on serological studies for Epstein-Barr virus (EBV) [1,2].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Chronic interstitial lung disease due to Epstein-Barr virus infection in two infants

Pfleger¹,

Eber²,

Popper³

et al. 2000

Eur Respir J

View full text Add to dashboard Cite

This case study reports on two infants, 5 and 6 months of age, respectively, with chronic interstitial lung disease who presented with failure to thrive, tachypnoea, rales and mild hypoxaemia.Epstein-Barr virus (EBV) was detected by in situ hybridization in lung biopsy specimens and by EBV-deoxyribonucleic acid-polymerase chain reaction (PCR) in bronchoalveolar lavage (BAL) fluid in one patient and by in situ hybridization and PCR analysis in BAL fluid in the second patient. There was serological evidence of immunoglobulin G antibodies to EBV capsid antigen by indirect immunofluorescence in both patients.After 7 months of respiratory symptoms one patient was successfully treated with a 10 day course of intravenous ganciclovir followed by oral acyclovir for 20 days. The other patient became symptom free after 3.5 months of respiratory symptoms, without any specific antiviral medication. During a follow-up of 2 and 1.5 yrs, respectively, both infants remained symptom free and showed normal physical development. Eur Respir J 2000; 15: 803±806.

show abstract

“…So far no association with EBV infection has been documented [2,22,23]. The chronic ILD observed in the current patients obviously did not progress into clearcut CFA.…”

Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic interstitial lung disease due to Epstein-Barr virus infection in two infants

Pfleger¹,

Eber²,

Popper³

et al. 2000

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…First, in very few cases, HRCT may be diagnostic. This is much less common than in adult ILD, but specific patterns, such as IPH, Langerhans cell histiocytosis (LCH; figure 5 Table 6 Presenting symptoms of ILD in children Table 7 When to suspect ILD in a child proteinosis (PAP) may be identified, obviating the need for further tests [12]. The second reason is to determine the site of a biopsy of the lung, which will probably be required in most cases.…”

Section: Imagingmentioning

confidence: 99%

“…In practice, there are a few groups of conditions that are particularly important [12][13][14]. Unsuspected immunodeficiency (for example HIV, hypogammaglobulinaemia) with any secondary opportunistic infection (and, in particular, Pneumocystis carinii pneumonia) may present as ILD.…”

Section: The Differential Diagnosismentioning

confidence: 99%