Chronic intermittent amphetamine pretreatment enhances future appetitive behavior for drug- and natural-reward: interaction with environmental variables

Nocjar, Christine; Panksepp, Jaak

doi:10.1016/s0166-4328(01)00321-7

Cited by 101 publications

(72 citation statements)

References 97 publications

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“…Interestingly, this AMPH experience also induced a significant up-regulation of AH-V1aR expression, similarly, as observed in pair-bonded males. While it is not surprising that drugs of abuse act on the same neurobiological substrates mediating natural reward (45)(46)(47)(48), our findings provide additional evidence to support the above notion and highlights the role of the neuropeptide AVP underlying naturally induced and drugfacilitated female-directed aggression in male prairie voles. These data also indicate the utility of the prairie vole model for evaluation of the effects of drug abuse on neural systems controlling adaptive forms of social behavior, such as mate guarding.…”

Section: Discussionsupporting

confidence: 69%

Anterior hypothalamic vasopressin regulates pair-bonding and drug-induced aggression in a monogamous rodent

Gobrogge

Liu

Young

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

155

177

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After pair-bonding, male prairie voles (Microtus ochrogaster) display aggression toward novel females but not toward their female partner. Here we show that this selective aggression in pair-bonded male prairie voles is associated with increased release of vasopressin (AVP) in the anterior hypothalamus (AH). Pharmacological activation of AVP-V1a receptors (V1aR) in the AH induced selective aggression in sexually naive males, whereas V1aR blockade diminished selective aggression in pair-bonded males. Pair-bonded males also showed an increased density in V1aR binding in the AH compared to their sexually naive counterparts and overexpression of V1aR in the AH, by viral vector-mediated gene transfer, facilitated aggression toward novel females. These data demonstrate that AH-AVP is both necessary and sufficient in the regulation of selective aggression associated with pair-bonding. In the second part of this study, we examined the effects of amphetamine (AMPH) exposure on female-directed aggression and revealed the potential role of AH-AVP underlying this behavior. Repeated AMPH administration in sexually naive male prairie voles enhanced V1aR expression in the AH and induced aggression toward a familiar or unfamiliar female. In addition, this AMPH-induced aggression was blocked by intra-AH administration of a V1aR antagonist. Together, our data reveal a socioneurobiological mechanism, highlighting a critical role of AH-AVP in the regulation of aggression induced by pair-bonding or drug experience in socially monogamous male prairie voles.behavioral pharmacology ͉ drug abuse ͉ microdialysis ͉ neural plasticity ͉ viral-vector gene transfer A ggression is an agonistic behavior that plays an important role for survival and reproductive success. In both vertebrates (1) and invertebrates (2), aggression promotes fitness by acquiring territory, food, and mates, as well as by serving to protect offspring and avoid predation. In humans and nonhuman primates, aggressive behavior operates within social hierarchies to facilitate resource acquisition (3). Among the neurochemicals implicated in aggression (4, 5), arginine vasopressin (AVP), and its homolog vasotocin, have been found to regulate several forms of aggression in numerous species (6, 7) across diverse taxa (8, 9). Even in humans, central AVP correlates with aggressive behavior (10) and mediates anger (11). Therefore, the AVP system may have evolved to be primed by a wide variety of experiences to induce aggression, when appropriate, in social animals (12).Drug use can override neurobiological programs to activate maladaptive forms of agonistic behavior, engaging inappropriate types of physical aggression (13), such as domestic violence (14) and intimate partner homicide (15). As a result, chronic drug abuse can cause permanent neural reorganization (16,17), impairing the adaptive social brain (18), leading to the display of maladaptive social behavior (19). In rodent models such as hamsters, adolescent exposure to cocaine (20) or anabolic steroids (21, 22) induces ag...

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Section: Discussionsupporting

confidence: 69%

Anterior hypothalamic vasopressin regulates pair-bonding and drug-induced aggression in a monogamous rodent

Gobrogge

Liu

Young

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

155

177

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“…Sensitizing pretreatments of D-amphetamine (10 daily injections of 1.5 mg/kg) facilitate sexual behavior (Fiorino and Phillips, 1999a,b) as well as approach behavior to sexual stimuli (Nocjar and Panksepp, 2002). Studies in female rats pretreated with Meth (three daily injections of 5 mg/kg) resulted in increased receptive behaviors (Holder et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Concurrent Exposure to Methamphetamine and Sexual Behavior Enhances Subsequent Drug Reward and Causes Compulsive Sexual Behavior in Male Rats

Frohmader¹,

Lehman²,

Laviolette³

et al. 2011

J. Neurosci.

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Methamphetamine (Meth) users report having heightened sexual pleasure, numerous sexual partners, and engaging in unprotected sex due to loss of inhibitory control. This compulsive sexual behavior contributes to increased prevalence of sexually transmitted infections, but the neural basis for this is unknown. We previously established a paradigm for compulsive sexual behavior in male rats in which visceral illness induced by lithium chloride was paired with sexual behavior (

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“…Such conditioned place preference is accompanied by increased DA turnover in the accumbens, and lesions to the accumbens disrupt apomorphine-induced place preference 51 and selfadministration. 54 In one study, 55 chronic amphetamine treatment in rats increased both amphetamineinduced place preference and appetitive behavior for food and sexual rewards. Animals that developed the strongest amphetamine-induced place preference, however, were not necessarily the same animals that developed magnified food and sex-seeking behaviors.…”

Section: Methods and Review Criteriamentioning

confidence: 99%

Insights into pathophysiology of punding reveal possible treatment strategies

Fasano

Petrović²

2010

Mol Psychiatry

111

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Punding is a stereotyped behavior characterized by an intense fascination with a complex, excessive, nongoal oriented, repetitive activity. Men tend to repetitively tinker with technical equipment such as radio sets, clocks, watches and car engines, the parts of which may be analyzed, arranged, sorted and cataloged but rarely put back together. Women, in contrast, incessantly sort through their handbags, tidy continuously, brush their hair or polish their nails. Punders are normally aware of the inapposite and obtuse nature of the behavior; however, despite the consequent self-injury, they do not stop such behavior. The most common causes of punding are dopaminergic replacement therapy in patients affected by Parkinson's disease (PD) and cocaine and amphetamine use in addicts. The vast majority of information about punding comes from PD cases. A critical review of these cases shows that almost all afflicted patients (90%) were on treatment with drugs acting mainly on dopamine receptors D1 and D2, whereas only three cases were reported in association with selective D2 and D3 agonists. Epidemiological considerations and available data from animal models suggest that punding, drug-induced stereotypies, addiction and dyskinesias all share a common pathophysiological process. Punding may be related to plastic changes in the ventral and dorsal striatal structures, including the nucleus accumbens, and linked to psychomotor stimulation and reward mechanisms. Possible management guidelines are proposed.

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Chronic intermittent amphetamine pretreatment enhances future appetitive behavior for drug- and natural-reward: interaction with environmental variables

Cited by 101 publications

References 97 publications

Anterior hypothalamic vasopressin regulates pair-bonding and drug-induced aggression in a monogamous rodent

Anterior hypothalamic vasopressin regulates pair-bonding and drug-induced aggression in a monogamous rodent

Concurrent Exposure to Methamphetamine and Sexual Behavior Enhances Subsequent Drug Reward and Causes Compulsive Sexual Behavior in Male Rats

Insights into pathophysiology of punding reveal possible treatment strategies

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