Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering

Abstract

Serhan and colleagues introduced the term "Resoleomics" in 1996 as the process of inflammation resolution. The major discovery of Serhan's work is that onset to conclusion of an inflammation is a controlled process of the immune system (IS) and not simply the consequence of an extinguished or "exhausted" immune reaction. Resoleomics can be considered as the evolutionary mechanism of restoring homeostatic balances after injury, inflammation and infection. Under normal circumstances, Resoleomics should be able to conclude inflammatory responses. Considering the modern pandemic increase of chronic medical and psychiatric illnesses involving chronic inflammation, it has become apparent that Resoleomics is not fulfilling its potential resolving capacity. We suggest that recent drastic changes in lifestyle, including diet and psycho-emotional stress, are responsible for inflammation and for disturbances in Resoleomics. In addition, current interventions, like chronic use of anti-inflammatory medication, suppress Resoleomics. These new lifestyle factors, including the use of medication, should be considered health hazards, as they are capable of long-term or chronic activation of the central stress axes. The IS is designed to produce solutions for fast, intensive hazards, not to cope with long-term, chronic stimulation. The never-ending stress factors of recent lifestyle changes have pushed the IS and the central stress system into a constant state of activity, leading to chronically unresolved inflammation and increased vulnerability for chronic disease. Our hypothesis is that modern diet, increased psycho-emotional stress and chronic use of anti-inflammatory medication disrupt the natural process of inflammation resolution ie Resoleomics.

Relevance of metal based Ayurvedic formulations in the management of recurrent acute/ chronic pancreatitis

“…Currently available treatments for CIDs involve prolonged use of anti-inflammatory drugs, including non steroidal anti-inflammatory drugs, corticosteroids and immune selective anti-inflammatory derivatives, which have considerable side effects (Bosma-den Boer et al, 2012). A recent review highlighted that current medications used to treat CIDs suppress the symptoms but prevent the complete resolution of the disease, leading to a persistent low grade inflammation.…”

“…A recent review highlighted that current medications used to treat CIDs suppress the symptoms but prevent the complete resolution of the disease, leading to a persistent low grade inflammation. Long lasting use of anti-inflammatory medications is also known to delay full recovery (Bosma-den Boer et al, 2012).…”

Broad-Spectrum Antibiotic Abuse and its Connection to Obesity

“…This immune response invariably results in low-grade, systemic inflammation, which has been termed, "the silent fire", due to its relatively unnoticeable effects on a macroscopic level until it reaches a chronic state [133]. Current studies have found that increased plasma levels of these pro-inflammatory cytokines are increased in the insulin resistant states of obesity and type 2 diabetes [134]. The proliferation of TNF-α in particular has been shown to promote additional pro-inflammatory cytokine release and an associated reduction in anti-inflammatory cytokines, such as adiponectin [135].…”

Resistance to Stresses and Reliability of Biological Systems: Insights for Genetic Studies of Human Aging, Health, and Longevity

“…Hence, the genetic polymorphisms that were able to efficiently interact with medical and health care interventions affecting variability in health and longevity are likely to be detectable in genetic association studies of those traits. Several recent publications provide evidence that a balanced diet rich in vitamins and other important nutrients contributes to an increase in individual resistance to stresses [22,23] and, hence, in lifespan and survival. The metabolism of different nutrients may involve genes from different signaling and metabolic pathways [24].…”