Chronic Inflammatory Demyelinating Polyneuropathy Incidence in Covid-19 and Covid-19 Vaccines

Abstract

Chronic Inflammatory Demyelinating Polyneuropathy [CIDP] is the most common autoimmune polyneuropathy in adults. CIDP is a demyelinating disease. It is an immune-mediated illness in which the precise mechanism behind the pathophysiology of the immune response is unknown. CIDP is an immune-mediated condition in which both T-cell and humoral mediated immune mechanisms act against myelin components. It is characterized by subacute to chronic onset [> 8 weeks], weakness [both proximal and distal], cyto-albuminologic dissociation [increased CSF protein without pleocytosis], and electrodiagnostic characteristics of asymmetric conduction velocity slowing with features of conduction block [1]. The presence of F-wave latency distinguishes CIDP from other demyelinating neuropathies [2,3]. Nerve pathology findings of CIDP are segmental demyelination, onion bulb formation, perineural inflammation, and axonal degeneration.