Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) in Diabetes Mellitus: A Diagnostic Dilemma

Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neurological disorder of the peripheral nerves which can lead to gradually increasing motor and sensory loss. It can be a difficult entity to diagnose, particularly in elderly patients with a history of Diabetes Mellitus due to their overlapping neuropathic syndromes. Reported is a case of CIDP in an elderly female who manifested multiple sensory, motor, and autonomic complaints. A compilation of clinical features, neuroimaging, lumbar puncture, electromyography, nerve conduction studies, and nerve biopsy were used to reach the diagnosis. Highlighted is a clinical approach to identifying CIDP that can cause neuropathy in the setting of other potential confounding disorders namely Diabetes Mellitus.

Difficult patient with polyneuropathy: CIDP associated with type 1 diabetes mellitus

“…Это заболевание, вызванное аутоиммунным процессом, в который вовлекаются нервные корешки, сплетения и стволы периферических нервов. Для типичной формы ХВДП характерна симметричная слабость в проксимальных и дистальных мышцах всех конечностей, снижение или отсутствие сухожильных рефлексов, снижение чувствительности по ПНП-типу [21]. При ХВДП, в отличие от синдрома Гийена -Барре, наблюдается прогрессирование симптомов более 8 нед.…”