Chronic Infection of Domestic Cats with Feline Morbillivirus, United States

Sharp, Claire R.; Nambulli, Sham; Acciardo, Andrew S.; Rennick, Linda J.; Drexler, Jan Felix; Rima, Bertus K.; Williams, Tracey; Duprex, W. Paul

doi:10.3201/eid2204.151921

Cited by 59 publications

(105 citation statements)

References 10 publications

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“…Therefore, the absence of N -linked glycans in the β-propeller domain appears to be a distinguishing feature of MojV-G, differentiating it not only from classical HNV-Gs182436373839 but also HN1920212223 and H3546 glycoproteins and the glycoproteins of the recently emerged feline morbillivirus404142, Mossman43, Nariva44 and Salem45 viruses. Our functional and structural characterization of the uniquely aglycosylated MojV-G β-propeller domain is suggestive that, in contrast to other paramyxoviral receptor-binding proteins, N -linked carbohydrates are unlikely to be required for native functionality or evasion of the host immune response.…”

Section: Resultsmentioning

confidence: 99%

Idiosyncratic Mòjiāng virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses

et al. 2017

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In 2012, cases of lethal pneumonia among Chinese miners prompted the isolation of a rat-borne henipavirus (HNV), Mòjiāng virus (MojV). Although MojV is genetically related to highly pathogenic bat-borne henipaviruses, the absence of a conserved ephrin receptor-binding motif in the MojV attachment glycoprotein (MojV-G) indicates a differing host-cell recognition mechanism. Here we find that MojV-G displays a six-bladed β-propeller fold bearing limited similarity to known paramyxoviral attachment glycoproteins, in particular at host receptor-binding surfaces. We confirm the inability of MojV-G to interact with known paramyxoviral receptors in vitro, indicating an independence from well-characterized ephrinB2/B3, sialic acid and CD150-mediated entry pathways. Furthermore, we find that MojV-G is antigenically distinct, indicating that MojV would less likely be detected in existing large-scale serological screening studies focused on well-established HNVs. Altogether, these data indicate a unique host-cell entry pathway for this emerging and potentially pathogenic HNV.

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Section: Resultsmentioning

confidence: 99%

Idiosyncratic Mòjiāng virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses

et al. 2017

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“… 1 Includes: Newcastle disease virus (NDV) and pigeon paramyxovirus; 2 synonym: anaconda paramyxovirus; 3 synonym: GH-M74a virus; 4 abbreviation as recently introduced in [26]; 5 historically, an isolate from a samango monkey (Cercopithecus mitis) in 1963 was long classified as a distinct species called simian agent 10 (SA-10), but was shown later to be HPIV-3. SA-10 was sometimes called SV-10;…”

Section: Tablementioning

confidence: 99%

Taxonomy of the order Mononegavirales: update 2016

et al. 2016

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In 2016, the order Mononegavirales was emended through the addition of two new families (Mymonaviridae and Sunviridae), the elevation of the paramyxoviral subfamily Pneumovirinae to family status (Pneumoviridae), the addition of five free-floating genera (Anphevirus, Arlivirus, Chengtivirus, Crustavirus, and Wastrivirus), and several other changes at the genus and species levels. This article presents the updated taxonomy of the order Mononegavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV).

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“…Indeed, serological responses to CDV were described recently in Tanzanian cattle [71]. In addition, a new spectrum of previously uncharacterized morbilliviruses has been identified in global bat and rodent populations [87], as well as a specific new morbillivirus in domestic cats [88]. There is therefore a critical requirement to develop novel approaches for assessing the risk of such transmission events taking place, for example by defining the capacity for animal morbilliviruses to interact with receptors from target species and by assessing the degree of cross-protection afforded by neutralizing antibodies.…”

Section: Examining the Potential For Inter-species (And Zoonotic) Tramentioning

confidence: 99%

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

Baron

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Njeumi

et al. 2017

Journal of General Virology

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Peste des petits ruminants virus (PPRV) is a significant pathogen of small ruminants and is prevalent in much of Africa, the Near and Middle East and Asia. Despite the availability of an efficacious and cheap live-attenuated vaccine, the virus has continued to spread, with its range stretching from Morocco in the west to China and Mongolia in the east. Some of the world's poorest communities rely on small ruminant farming for subsistence and the continued endemicity of PPRV is a constant threat to their livelihoods. Moreover, PPRV's effects on the world's population are felt broadly across many economic, agricultural and social situations. This far-reaching impact has prompted the Food and Agriculture Organization of the United Nations (FAO) and the World Organisation for Animal Health (OIE) to develop a global strategy for the eradication of this virus and its disease. PPRV is a morbillivirus and, given the experience of these organizations in eradicating the related rinderpest virus, the eradication of PPRV should be feasible. However, there are many critical areas where basic and applied virological research concerning PPRV is lacking. The purpose of this review is to highlight areas where new research could be performed in order to guide and facilitate the eradication programme. These areas include studies on disease transmission and epidemiology, the existence of wildlife reservoirs and the development of next-generation vaccines and diagnostics. With the support of the international virology community, the successful eradication of PPRV can be achieved.

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Chronic Infection of Domestic Cats with Feline Morbillivirus, United States

Cited by 59 publications

References 10 publications

Idiosyncratic Mòjiāng virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses

Idiosyncratic Mòjiāng virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses

Taxonomy of the order Mononegavirales: update 2016

Future research to underpin successful peste des petits ruminants virus (PPRV) eradication

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