Chronic Indwelling Urinary Catheter Increase the Risk of Bladder Cancer, Even in Patients Without Spinal Cord Injury

Abstract

Chronic indwelling urinary catheters (CIDCs) are known as a risk factor for bladder cancer in patients with spinal cord injury (SCI). This study examined the potential risk of bladder cancer from CIDCs in patients without SCI.The National Health Insurance Research Database in Taiwan was used to identify SCI patients (N = 1816). This group was compared against a control CIDC cohort without SCI (N = 1816) and a reference cohort with normal individuals without SCI and a record of CIDC (N = 7264). Comparisons were made based on age and gender matching over a maximum of 11 follow-up years. The incidence risk and hazard ratio (HR) of bladder cancer were estimated in all 3 groups.During the follow-up period, the bladder cancer incidence rates were 68.90 and 102.53 per 100,000 person-years in the SCI and CIDC-non-SCI groups, respectively. These values were both higher than that of the reference cohort (12.00 per 100,000 person-years). Patients who had history of SCI (HR: 6.51; 95% CI, 2.56–16.52) or CIDC without SCI (HR: 9.11; 95% CI, 3.9–21.29) had a higher risk of bladder cancer compared with the reference cohort.Patients with CIDCs may have an increased risk of bladder cancer development, especially in older aged and male patients compared with general population.

Comparison of the efficacy and feasibility of en bloc transurethral resection of bladder tumor versus conventional transurethral resection of bladder tumor

“…[7] Unfortunately, bladder tumor is bound up with high recurrence rates (50%–70%) after transurethral resection management, and tumor cell implantation is deemed to be a major cause of early recurrence. [8,9] Thus, it is reasonable to modify TURBT to provide en bloc transurethral resection of bladder tumor (ETURBT) of the specimen, based on the established oncological principle of dissecting through normal tissue. [10] Several studies have examined the efficacy and feasibility of en bloc TURBT.…”

<p>Rehabilitation to Improve the Function and Quality of Life of Soft Tissue and Bony Sarcoma Patients</p>

“…Long-term indwelling catheters should be avoided due to the increased risk of infection and bladder cancer. 48 A bowel regimen consisting of softeners and stimulants should be titrated such that a patient has a complete bowel movement every day or every other day. Patients may be able to utilize sacral reflexes to achieve bowel continence using suppositories and/or digital stimulation to promote emptying.…”

Querschnittlähmung mit neurogener Harnblasenfunktionsstörung als möglicher Risikofaktor für Harnblasenkarzinome

“…Eine Metaanalyse [5] der vorliegenden Studien berechnet die Häufigkeit von Plattenepithelkarzinomen bei Querschnittgelähmten mit 36,8 % (95 %-KI 31,6-42,5; I 2 = 32,3 %) und von Urothelkarzinomen mit 46,3 % (95 %-KI 33,7-59,4; I 2 = 40,5 %). Andere pathologische Subtypen waren mit einer Häufigkeit von 17,1 % (95 %- KI 12,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]6; I 2 = 21,5 %) vertreten.…”

“…Im Gegensatz hierzu fanden Ho et al [17] an 1816 querschnittgelähmten Patienten mit einem maximalen Follow-up von 11 Jahren eine Inzidenzrate für Harnblasenkarzinome von 68,9/ 100 000 Personenjahre (rohe Häufigkeit 10/1816 = 0,55 %). Die Inzidenzrate war damit um den Faktor 8,55 (95 %-KI 3,66-19,97; p < 0,001) höher als in einer Kontrollgruppe ohne Rückenmarkschädigung (Inzidenzrate von 12,0/100 000 Personenjahre; = 7264).…”