Chronic Impairment of Prospective Memory after Mild Traumatic Brain Injury

Tay, Sze Yan; Ang, Beng Ti; Lau, Xin Yin; Meyyappan, Amutha; Collinson, Simon L.

doi:10.1089/neu.2009.1074

Cited by 46 publications

(24 citation statements)

References 37 publications

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“…Recent research 57 indicates that the most frequently damaged white-matter structures in concussed persons are those subserving memory and cognitive control. Accordingly, investigators have observed persistent concussion-related deficits across various aspects of cognitive control, including prospective and working memory, 18,28,59 mental flexibility, 22 and interference and inhibition. 20,22,26 Thus, cognitive control functions and their neural generators appear particularly sensitive to the effects of sport-related concussion.…”

Section: Discussionmentioning

confidence: 99%

“…However, the transient view of concussion has recently come into question, as a growing body of evidence illustrates numerous chronic nervous system dysfunctions and cognitive deficits stemming from these injuries. [18][19][20][21][22][23][24][25][26][27][28] Further, recent epidemiologic reports 16,29 reveal increased prevalence of mild cognitive impairment, dementia, and Alzheimer disease in retired contact-sport athletes. Evidence from these studies appears to diverge from the concept of concussion as a transient injury.…”

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confidence: 99%

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The Persistent Influence of Concussive Injuries on Cognitive Control and Neuroelectric Function

Moore

Hillman

Broglio

2014

Journal of Athletic Training

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Context: Increasing attention is being paid to the deleterious effects of sport-related concussion on cognitive and brain health.Objective: To evaluate the influence of concussion incurred during early life on the cognitive control and neuroelectric function of young adults.Design: Cross-sectional study. Setting: Research laboratory.Patients or Other Participants: Forty young adults were separated into groups according to concussive history (0 or 1þ). Participants incurred all injuries during sport and recreation before the age of 18 years and were an average of 7.1 6 4.0 years from injury at the time of the study.Intervention(s): All participants completed a 3-stimulus oddball task, a numeric switch task, and a modified flanker task during which event-related potentials and behavioral measures were collected.Main Outcome Measure(s): Reaction time, response accuracy, and electroencephalographic activity.Results: Compared with control participants, the concussion group exhibited decreased P3 amplitude during target detection within the oddball task and during the heterogeneous condition of the switch task. The concussion group also displayed increased N2 amplitude during the heterogeneous version of the switch task. Concussion history was associated with response accuracy during the flanker task.Conclusions: People with a history of concussion may demonstrate persistent decrements in neurocognitive function, as evidenced by decreased response accuracy, deficits in the allocation of attentional resources, and increased stimulusresponse conflict during tasks requiring variable amounts of cognitive control. Neuroelectric measures of cognitive control may be uniquely sensitive to the persistent and selective decrements of concussion.Key Words: concussions, inhibition, mental flexibility, attention, P3, N2 Key PointsSeven years after concussion, participants displayed disrupted higher-order neurocognition in the form of chronically impaired attention, working memory, inhibition, and interference control. The observed deficits in attention and conflict monitoring were only evident when cognitive demands were increased. Subtle deficits may remain unrecognized with other types of testing.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

The Persistent Influence of Concussive Injuries on Cognitive Control and Neuroelectric Function

Moore

Hillman

Broglio

2014

Journal of Athletic Training

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“…PM deficits are associated with self-rated memory problems even more frequently than retrospective memory disorders (Kinsella et al 1996) and they are a relatively common features in various neurological populations. Indeed, a significant decline in PM performance has been documented in individuals suffering from the long-lasting consequences of severe head trauma (Carlesimo et al 2004;Groot et al 2002;Henry et al 2007;Tay et al 2010), Parkinson's disease without dementia (Katai et al 2003;Kliegel et al 2005;Costa et al 2008a, b), epilepsy (Adda et al 2008), thalamic stroke (Carlesimo et al 2011), and focal lesions involving the prefrontal cortex (Burgess 2000). Early impairment of PM has been observed in AD (Huppert et al 2000;Maylor et al 2002) and data from a previous study demonstrated that failure on a PM task was more accurate than traditional tests of retrospective memory in discriminating between persons in the very early stage of dementia and healthy subjects (Huppert and Beardsall 1993).…”

Section: Prospective Memory: a Definitionmentioning

confidence: 99%

Prospective Memory Impairment in Mild Cognitive Impairment: An Analytical Review

2011

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Mild cognitive impairment (MCI) is a heterogeneous condition characterized by the presence in an otherwise healthy elderly individual of cognitive deficits involving specific domains in the absence of significant functional impairments. Reports indicate that prospective memory (PM), that is, the ability to remember to execute delayed intentions, is impaired in individuals with MCI. The present review discusses the current debate in the literature on PM functioning in MCI by focusing on the relationship between prospective retrieval and retrospective memory functioning. Analysis of the reported evidence revealed that both the prospective component and the retrospective component of PM can be impaired in MCI. Declarative memory dysfunction may account for the retrospective memory impairment, while either reduced executive abilities or a deficit of reflexive mechanisms could explain the prospective component impairment.

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“…However, more recent studies using highly sensitive assessment measures suggest that a multitude of chronic nervous system dysfunctions and cognitive deficits stem from concussive injuries. [16][17][18][19][20][21][22][23][24][25][26][27][28] Thus, the chronic, subclinical effects of concussion remain unclear, and measures sensitive to subtle and persistent deficits stemming from concussion are needed.…”

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confidence: 99%