“…In addition to the well known receptor actions of antidepressants (Sugrue, 1983;Sulser, 1983;Vetulani, 1984) there is some evidence to suggest that these drugs may also have intracellular actions (Albouz etal., 1982;Bal etal., 1987;Bal, 1989;Bal and Bird, 1990;Honegger et al, b, 1988Smialowska et al, 1988). We have previously shown that amitriptyline (AMI), desipramine (DMI), mianserin (MIA) and citalopram (CIT) affect the ultrastructure of nerve cells when dissociated cultures of embryonic rat cingulate cortex are chronically exposed to these drugs (Bal and Bird, 1990).…”