Chronic Idiopathic Neutrophilia

Weir, Alva B.; Lewis, James B.; Arteta-Bulos, Rafael

doi:10.1097/smj.0b013e31821ec7cc

Cited by 13 publications

(5 citation statements)

References 21 publications

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“…We know however that inflammatory markers have a temporal relationship to smoking,25 and this might explain the delay in CIN presentation. Cigarette smoking was suggested as a potential cause for this condition in our patient after an extensive diagnostic analysis excluded other possible conditions or intake of medications such as corticosteroids and lithium which are associated with neutrophilia 9. Despite the use of medically-approved methods, the patient failed to quit smoking.…”

Section: Discussionmentioning

confidence: 86%

“…Chronic idiopathic neutrophilia (CIN) is a condition characterized by asymptomatic elevation of white blood cells (WBCs) and neutrophil count that persists for years without any underlying disease 9. Smoking has been implicated as a cause of this condition,9,10 and leukocyte count is a predictor of future cardiovascular events 11,12…”

Section: Introductionmentioning

confidence: 99%

“…Smoking has been implicated as a cause of this condition,9,10 and leukocyte count is a predictor of future cardiovascular events 11,12…”

Section: Introductionmentioning

confidence: 99%

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Chronic Idiopathic Neutrophilia in A Smoker, Relieved after Smoking Cessation with the Use of Electronic Cigarette: A Case Report

Farsalinos

Romagna²

2013

Clin Med Insights Case Rep

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Introduction:Smoking is a major risk factor for a variety of diseases. Electronic cigarettes are battery-operated devices that deliver nicotine to the lungs by evaporation of a liquid. Chronic idiopathic neutrophilia is a condition characterized by elevated white blood cell and neutrophil counts without any underlying disease; smoking has been implicated as a potential cause.Case Presentation:A male Caucasian patient, born in 1977, presented in September 2005 with asymptomatic elevation of white blood cell and neutrophil count, and mildly-elevated C-reactive protein levels. He was a smoker since 1996 and was treated with 20 mg/day of simvastatin since 2003 due to hyperlipidemia. Clinical examination, and laboratory and imaging investigations ruled out any infectious, haematological, rheumatological, or endocrine conditions. He was followed-up regularly and was advised to stop smoking. He had 2 unsuccessful attempts to quit smoking; one was unassisted and the second was performed with the use of both varenicline and nicotine replacement therapy (patches). During the subsequent 6.5 years, his leukocyte and C-reactive protein levels were repeatedly elevated; the condition was consistent with chronic idiopathic neutrophilia. In February 2012, he started using electronic cigarettes and he managed to quit smoking within 10 days. After 6 months, laboratory examination showed normalized leukocyte count and C-reactive protein levels, confirmed immediately by a second laboratory and by repeated tests after 1 and 2 months.Conclusion:Smoking cessation with the use of electronic cigarette led to reversal of chronic idiopathic neutrophilia. The daily use of electronic cigarette may help preserve the beneficial effects of smoking cessation.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Chronic Idiopathic Neutrophilia in A Smoker, Relieved after Smoking Cessation with the Use of Electronic Cigarette: A Case Report

Farsalinos

Romagna²

2013

Clin Med Insights Case Rep

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“…Finally focused history and physical examination, complete blood count, and chemistry profile must be repeated at 2, 6, and 12 months and annually thereafter. Additional testing, including PCR or FISH techniques for bcr-abl, JAK-2 mutational testing, erythropoietin levels, and bone marrow examination with cytogenetics, must be warranted for patients suspected of having a myeloproliferative neoplasm [3]. …”

Section: Discussionmentioning

confidence: 99%

“…CIN is rarely mentioned in scientific literature and in academic books of hematology; only few words are dedicated to this topic. The most extensive contribution to the definition of CIN is a recent study by Weir and colleagues who reported a cohort of 134 adult patients with leukocyte count between 11000 and 40000/mm 3 without other clinical or hematologic comorbidities, except for the fact that many of them were smokers [3]. …”

Section: Introductionmentioning

confidence: 99%

Chronic Idiopathic Neutrophilia in Two Twins

Miniero

Mazza

Altomare

et al. 2014

Case Reports in Hematology

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Neutrophilia in adults refers to an alteration in the total number of blood neutrophils that is in excess of about 7500 cells/μL. This definition is restrictive in childhood as neutrophil count is age-dependent. Chronic Idiopathic Neutrophilia (CIN) refers to a condition that persists for many years in individuals who appear otherwise healthy. CIN is rarely mentioned in scientific literature and in academic books of hematology; only few words are dedicated to this topic. We report a case study of two twins with CIN followed from the first year of life to 24 years of age. To the best of our knowledge this is the first case report of two twins with CIN followed through a long period of time. We believe that our observation may contribute to better understand and characterize this hematologic abnormality.

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Standardized pretreatment inflammatory laboratory markers and calculated ratios in patients with oral squamous cell carcinoma

Grimm¹,

Rieth²,

Hoefert³

et al. 2016

Eur Arch Otorhinolaryngol

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Analyzing the inflammatory microenvironment has become an important issue in the management of oral squamous cell carcinoma (OSCC). Pretreatment C-reactive protein (CRP) levels, leucocytes, monocytes, lymphocytes, neutrophils, basophils, eosinophils, platelets, neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) derived from the peripheral blood were analyzed. Receiver operating characteristic (ROC) curves determined a cut-off value for each parameter in 146 patients with OSCC compared with 93 controls and the results were associated with clinicopathological characteristics. CRP expression of tumors was measured by immunohistochemistry. ROC analysis determined cut-off values for CRP levels, leucocytes, monocytes, lymphocytes, neutrophils, NLR, dNLR, LMR, PLR and showed significant differences between the OSCC and control group. Compared with single laboratory tests calculated ratios were superior in measuring sensitivity and specificity of OSCC disease. NLR was significant directly associated and correlated with PLR. LMR was significant inversely associated and correlated with NLR and PLR. Immunohistochemical analysis did not show CRP expression of OSCCs. This study highlights the first analysis for cut-off values of pretreatment single laboratory tests and calculated ratios, which are strongly needed for a follow-up of cancer patients. Additionally, the calculated baselines can be used as a goal for successful immunotherapies in the future. The links between NLR, LMR, and PLR might be helpful for the clinical course (monitoring) of cancer patients and have been first described for OSCC in this study. Taken together, analyzing these data provides an additional practical guideline of further postoperative OSCC management.

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Chronic Idiopathic Neutrophilia

Cited by 13 publications

References 21 publications

Chronic Idiopathic Neutrophilia in A Smoker, Relieved after Smoking Cessation with the Use of Electronic Cigarette: A Case Report

Chronic Idiopathic Neutrophilia in A Smoker, Relieved after Smoking Cessation with the Use of Electronic Cigarette: A Case Report

Chronic Idiopathic Neutrophilia in Two Twins

Standardized pretreatment inflammatory laboratory markers and calculated ratios in patients with oral squamous cell carcinoma

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