Chronic Idiopathic Axonal Polyneuropathy and Successful Aging of the Peripheral Nervous System in Elderly People

Vrancken, Alexander F.J.E.; Franssen, Hessel; Wokke, John H. J.; Teunissen, Laurien L.; Notermans, Nicolette C.

doi:10.1001/archneur.59.4.533

Cited by 74 publications

(68 citation statements)

References 43 publications

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“…Just as Alzheimer disease, osteoarthritis, and presbycusis were once considered inevitable consequences of aging, "idiopathic" peripheral neuropathy has been neglected as a potentially preventable and/or treatable condition. Vrancken et al 8 have demonstrated that age at onset of chronic idiopathic axonal polyneuropathy makes little difference in the neurological and electrophysiological findings, although patients with early onset and more rapid progression are more likely to become disabled, characteristics reminiscent of Alzheimer disease.…”

mentioning

confidence: 99%

The Prevalence, Predictors, and Consequences of Peripheral Sensory Neuropathy in Older Patients

Mold

Vesely²,

Keyl³

et al. 2004

The Journal of the American Board of Family Medicine

212

135

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Background:The prevalence, predictors, and consequences of peripheral neuropathy in the elderly have not been well defined.Methods: Seven hundred ninety-five noninstitutionalized patients 65 years of age and older, recruited from the practices of family physicians, completed questionnaires and underwent peripheral neurologic examinations and tests of gait and balance. Variables included sociodemographic information, medical conditions, symptoms (numbness, pain, trouble with balance or walking, and restless legs), quality of life measures, ankle reflexes, position sense, vibratory sense, fine touch sensation, Tinnetti balance examination, and a 50-foot timed walk.Results: The prevalence of at least one bilateral sensory deficit rose from 26% for 65-to 74-yearolds to 54% for those 85 and older. The most common deficit was loss of ankle reflex followed by loss of fine touch. Only 40% of those with bilateral deficits reported having a disease known to cause peripheral neuropathy. Predictors of bilateral deficits included increasing age, income less than $15,000, a history of military service, increasing body mass index, self-reported history of diabetes mellitus, Vitamin B 12 deficiency or rheumatoid arthritis, and absence of a history of hypertension. Deficits were associated with numbness, pain, restless legs, trouble walking, trouble with balance, and reduced quality of life.Conclusions

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mentioning

confidence: 99%

The Prevalence, Predictors, and Consequences of Peripheral Sensory Neuropathy in Older Patients

Mold

Vesely²,

Keyl³

et al. 2004

The Journal of the American Board of Family Medicine

212

135

View full text Add to dashboard Cite

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“…A large number of early studies reported that the spontaneous discharges were caused by the various denervations [101][102][103][104][105][106][107][108][109][110][111]. These spontaneous discharges that manifested fibrillation potentials were also termed "denervation potentials" in some reports.…”

Section: Denervation Supersensitivitymentioning

confidence: 99%

“…These spontaneous discharges that manifested fibrillation potentials were also termed "denervation potentials" in some reports. The spontaneous and rhythmical repetitive discharges were originated in skeletal muscles due to the denervation process [101][102][103][104][105], and the spontaneous firing activity of muscle fiber that manifested fibrillation potentials was regarded as the safe criteria for the clinical diagnosis of denervation. The spontaneous depolarizing excitations of striatal neurons were observed after the denervation caused by 6-hydroxydopamine-induced lesions of the nigrostriatal dopaminergic system [106][107][108][109][110][111].…”

Section: Denervation Supersensitivitymentioning

confidence: 99%

Spontaneous high-frequency action potential

Shen

Choe

2011

Sci. China Life Sci.

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Action potential, which is the foundation of physiology and electrophysiology, is most vital in physiological research. This work starts by detecting cardiac electrophysiology (tachyarrhythmias), combined with all spontaneous discharge phenomena in vivo such as wound currents and spontaneous neuropathic pain, elaborates from generation, induction, initiation, to all of the features of spontaneous high-frequency action potential--SSL action potential mechanism, i.e., connecting-end hyperpolarization initiates spontaneous depolarization and action potential in somatic membrane. This work resolves the conundrums of in vivo spontaneous discharge in tachyarrhythmias, wounds, denervation supersensitivity, neurogenic pain (hyperalgesia and allodynia), epileptic discharge and diabetic pain in pathophysiological and clinical researches that have puzzled people for a hundred years. action potential, spontaneous high-frequency action potential, tachyarrhythmias, atrial fibrillation, wound, denervation supersensitivity, neurogenic pain, hyperalgesia and allodynia, epileptic discharge, diabetic pain, regeneration and development Citation:Shen H Y, Choe W C. Spontaneous high-frequency action potential. Sci China Life Sci, 2011Sci, , 54: 311 -335, doi: 10.1007 Wound, nerve disconnection, and atrial fibrillation (AF) induced by the excessive atrial dilation, are commonly characterized by the spontaneous repetitive discharge. Their common induction is the disconnection of intercellular connection, and their common result is the initiation of spontaneous high-frequency discharge, which discloses the existence of the special action of intercellular connection.The Hodgkin-Huxley model has predicted, and the computer models in applied mathematics have well demonstrated, that potassium leakage causes persistent spontaneous electrifying state with spontaneous oscillation of high-frequency action potential. The sustained disconnection of connecting-end space induces potassium leakage in the connecting-end and consequently the sustained reduction of [K + ] i , which induces in vivo spontaneous high-frequency action potential in plasmalemma.To form an intercellular conduction, connecting-end space exerts action on ion diffusions, the alteration of the space alters ion diffusions (i.e., ionic permeability) in the connecting-end. The abolishment of connecting-end space action causes K + leakage and consequently the reduction of intracellular positive electropotential (IPE) (i.e., the increase of intracellular negative potential), which elevates resting somatic membrane potential and initiates action potential in somatic membrane. SSL action potential is named to the course from the initiation (i.e., connecting-end hyperpolarization) to the termination of somatic membrane action potential.Tachyarrhythmias that are characterized by spontaneous discharge have been most deeply studied. Their inductions contain both mechanical actions and chemical actions, and their courses contain the transformation from traditional action potential to SSL-ty...

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“…It is generally accepted to coin the disorder chronic idiopathic axonal polyneuropathy (Notermans et al, 1993;Wolfe et al, 1999;Vrancken et al, 2002;Hughes et al, 2004). The disease shows a male pre-dominance and seems to be a common hospital-referred polyneuropathy (McLeod et al, 1984;Wolfe et al, 1999;Vrancken et al, 2002;Teunissen et al, 2000;Mygland and Monstad, 2001;Rudolph and Farbu, 2007). Re-evaluation is often not recommended as no cause of the polyneuropathy is found after repeated follow-up investigation (Notermans *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, quality of life may be reduced at long-term follow-up (Notermans et al, 1994;Wolfe et al, 1999;Vrancken et al, 2002). It has been shown that physical, mental, emotional and social wellbeing seem to be impaired up to one decade after onset (Hughes et al, 2004;Teunissen et al, 2000;Erdmann et al, 2007;Rudolph et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Chronic idiopathic polyneuropathy: Patients own perception of well-being in correlation to clinical condition

Rudolph¹,

Larsen²,

Farbu³

2011

J. Clin. Med. Res.

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Chronic idiopathic polyneuropathy (CIP) is a disease of the elderly where further follow-up is usually not indicated after diagnosis. The aim of the study was to evaluate the self-reported functioning and well-being in patients with CIP in correlation to clinical findings. We examined forty-eight patients with CIP. The Fatigue Severity Scale, Visual Analogue Scale for pain, Disability Rating Index, Berg Balance test and Medical Outcome Study 36-item short-form health status scale were correlated with clinical variables at long-term follow-up. Predominantly sensory symptoms and signs were found. Reduced balance and sensory function explained up to 31% of variance in self-reported physical impairment (p < 0.0001). Otherwise, self-reported functioning and well-being could not be explained by clinical symptoms. Sensory deficits and balance problems are typical in CIP, and reduced balance and sensory functioning partially explained impaired physical functioning and well-being. Further follow-up could be indicated to investigate the effect of specific training programs and whether other factors may contribute to impaired functioning and well-being as well.

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Chronic Idiopathic Axonal Polyneuropathy and Successful Aging of the Peripheral Nervous System in Elderly People

Cited by 74 publications

References 43 publications

The Prevalence, Predictors, and Consequences of Peripheral Sensory Neuropathy in Older Patients

The Prevalence, Predictors, and Consequences of Peripheral Sensory Neuropathy in Older Patients

Spontaneous high-frequency action potential

Chronic idiopathic polyneuropathy: Patients own perception of well-being in correlation to clinical condition

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