Abstract:This study explores the hypothesis that chronic hypoxia alters the expression and intracellular coupling of endothelin receptors to induce phenotypic transformations of smooth muscle cells within the arteries of fetal cerebrovasculature. Endothelium‐denuded middle cerebral arteries (MCAs) harvested from term fetuses of pregnant adult sheep kept at sea level or 3820m for 110 days were used in contractility experiments or cultured with ET‐1 and various kinase inhibitors. Chronic hypoxia had no effect on plasma l… Show more
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