2020
DOI: 10.21203/rs.2.24505/v1
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Chronic hypoxaemia and gender status modulate adiponectin pathway in severe COPD patients: new endotypic presentation?

Abstract: Background: Disease progression in COPD patient is associated to lung function decline, leading to a higher risk of hypoxaemia and associated comorbidities, notably cardiovascular diseases (CV). Gender is also known to influence CV risk. Adiponectin (Ad), a cardio-protective hormone, was suggested as a biomarker for COPD risk management. However, determinants and consequences of Ad pathway modulation in COPD are unknown and gender specificities are poorly understood. We postulated that hypoxaemia and gender co… Show more

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