Chronic Human Glaucoma Causing Selectively Greater Loss of Large Optic Nerve Fibers

Quigley, Harry A.; Dunkelberger, Gregory R.; Green, W. Richard

doi:10.1016/s0161-6420(88)33176-3

Cited by 585 publications

(409 citation statements)

References 9 publications

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“…13 The qualitative analysis methods currently available are standard achromatic perimetry (SAP) and the more sensitive short-wavelight automated perimetry (SWAP) 14,15 as well as the recent frequency-doubling technology (FDT) perimetry. [16][17][18] There is also still some debate as to whether the appearance of neuronal changes and perimetric damage are vascular or mechanical phenomena.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Cellini

Bernabini

Carbonelli

et al. 2006

Eye

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Purpose To study in ocular hypertension (OH) the retinal nerve fibre layer (RNFL) with optical coherence tomography (OCT) and the neuronal function with frequency-doubling technology (FDT) to assess which of the two methods was more sensitive in detecting early glaucomatous damage. Furthermore, a colour Doppler imaging (CDI) of the optic nerve was carried out to highlight any correlation with RNFL thickness and FDT abnormality. Materials and methods We enrolled 28 ocular hypertensive patients who underwent OCT of the RNFL and FDT. Moreover, we performed a CDI of the ophthalmic artery (OA), central retinal artery (CRA), and posterior ciliary arteries (PCAs). Results The patients with OH following OCT revealed a significant thinning in the RNFL as compared to the control group only in the inferior quadrant: 122.250714.091 vs 131.750710.729 lm (Po0.045). As regards FDT, there was a significant difference between the two groups only for pattern standard deviation (PSD): 3.87371.488 vs 1.93870.704 dB (Po0.044). In OH and in the control group, CDI resistance index (RI) in the OA was 0.76870.012 vs 0.74570.019 (Po0.022), in the CRA was 0.6670.012 vs 0.64570.019 (Po0.032), and in PCAs was 0.67370.039 vs 0.62270.012 (Po0.037). The OCT had a sensitivity of 83% but only in the inferior RNFL quadrant. The FDT-PSD revealed a sensitivity of 85%. Conclusions Both FDT and OCT detect early glaucomatous damage with a slightly superior sensitivity of FDT vs OCT. The CDI measurements suggest that circulatory abnormalities may have a role in the development of OCT and FDT damage.

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Section: Introductionmentioning

confidence: 99%

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Cellini

Bernabini

Carbonelli

et al. 2006

Eye

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“…It remains unclear whether some ganglion cells are more susceptible to apoptosis than are others, under glaucomatous conditions [Quigley, 1999]. Early studies indicated that large ganglion cells (magnocellular ganglion cells) and nerve fibers were selectively lost in experimental glaucoma models in nonhuman primates, and in human glaucoma patients [Quigley et al, 1988]. In support of these observations, another work found selective loss of anterograde axonal transport to the magnocellular layer of the dorsal lateral geniculate nucleus, which is the region containing the largest RGCs [Dandone et al, 1991].…”

Section: Glaucoma and Retinal Ganglion Cell Deathmentioning

confidence: 99%

Retinal Ganglion Cell Death

Budak¹,

Joshi²

2011

Glaucoma - Basic and Clinical Concepts

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“…While the cell soma is the principal site for energy production and protein synthesis, there is evidence that the axon in its own right, has, to supplement some of these functions. If the median value for the soma diameter for larger retinal ganglion cells (mostly parasol cells) is taken as 19 mm, mean the axon diameter as 0.95 mm and axon length as 5 cm based on published data, 13,14 it can be shown that the axon volume would comprise 80% of the total cell volume. If comparison is made on the basis of cell area (which provides a better estimate of metabolic demand), the disparity is more marked with the axon comprising 93% of the cell area.…”

Section: Axon Dimensionsmentioning

confidence: 99%

Circulation and axonal transport in the optic nerve

Morgan

2004

Eye

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Retinal ganglion cells are the output cells of the retina whose axons are under considerable metabolic stress in both health and disease states. They are highly polarised to ensure that mitochondria and enzymes involved in the generation of ATP are strategically concentrated to meet the local energy demands of the cell. In passing from the eye to the brain, axons are protected and supported by glial tissues and the blood supply of the optic nerve head is regulated to maintain the supply of oxygen and nutrients to the axons.In spite of this, the optic nerve head remains the point at which retinal ganglion cell axons are most vulnerable to the effects of increased intraocular pressure or ischaemia. Considerable work has been undertaken in this area to advance our understanding on the pathophysiology of axon damage and to develop new strategies for the prevention of retinal ganglion cell death.

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Chronic Human Glaucoma Causing Selectively Greater Loss of Large Optic Nerve Fibers

Cited by 585 publications

References 9 publications

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Retinal Ganglion Cell Death

Circulation and axonal transport in the optic nerve

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