Chronic high-fat diet affects food-motivated behavior and hedonic systems in the nucleus accumbens of male rats

Arcego, Danusa Mar; Krolow, Rachel; Lampert, Carine; Toniazzo, Ana Paula; Garcia, Emily dos Santos; Lazzaretti, Camilla; Costa, Gustavo; Scorza, Cecilia; Dalmaz, Carla

doi:10.1016/j.appet.2020.104739

Cited by 35 publications

(23 citation statements)

References 48 publications

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“…An interesting recent study demonstrated that rats fed chronic HFD (42% fat) for 10 weeks post weaning showed a motivational impairment for sweet palatable foods, in terms of increased latency to start eating and diminished amount of ingested sweet palatable cereals or chocolate tablets [55]. In line with this, rats fed a HFD (60% fat) for 16 weeks showed diminished sucrose preference, increased anxiety and anhedonia [56], supporting that obese animals presenting anhedonia may lose their natural preference for sweet solutions [57].…”

Section: Discussionmentioning

confidence: 99%

Behavioral and Metabolic Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation in Obese Male Rats

et al. 2021

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Diet-induced obesity models are widely used to investigate dietary interventions for treating obesity. This study was aimed to test whether a dietary intervention based on a calorie-restricted cafeteria diet (CAF-R) and a polyphenolic compound (Oleuropein, OLE) supplementation modified sucrose intake, preference, and taste reactivity in cafeteria diet (CAF)-induced obese rats. CAF diet consists of high-energy, highly palatable human foods. Male rats fed standard chow (STD) or CAF diet were compared with obese rats fed CAF-R diet, alone or supplemented with an olive tree leaves extract (25 mg/kg*day) containing a 20.1% of OLE (CAF-RO). Biometric, food consumption, and serum parameters were measured. CAF diet increased body weight, food and energy consumption and obesity-associated metabolic parameters. CAF-R and CAF-RO diets significantly attenuated body weight gain and BMI, diminished food and energy intake and improved biochemical parameters such as triacylglycerides and insulin resistance which did not differ between CAF-RO and STD groups. The three cafeteria groups diminished sucrose intake and preference compared to STD group. CAF-RO also diminished the hedonic responses for the high sucrose concentrations compared with the other groups. These results indicate that CAF-R diet may be an efficient strategy to restore obesity-associated alterations, whilst OLE supplementation seems to have an additional beneficial effect on sweet taste function.

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Section: Discussionmentioning

confidence: 99%

Behavioral and Metabolic Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation in Obese Male Rats

et al. 2021

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“…Our hypotheses that HFD intake would induce sucrose anhedonia and HFD replacement would reduce consumption of a new, less palatable diet were supported but, although HF-fed males took slightly longer to approach sucrose during NIH, we did not report significant diet effects on latency. Conversely, latency to consume chow was increased after HFD feeding during NIH [ 29 ], suggesting that HFD intake herein did not alter anxiety due to a novel environment but similar latency to approach sucrose between diet groups could be due to greater salience for sucrose compared to chow. It is possible that KORs could account for these effects.…”

Section: Discussionmentioning

confidence: 99%

Replacing a Palatable High-Fat Diet with a Low-Fat Alternative Heightens κ-Opioid Receptor Control over Nucleus Accumbens Dopamine

et al. 2021

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Diet-induced obesity reduces dopaminergic neurotransmission in the nucleus accumbens (NAc), and stressful weight loss interventions could promote cravings for palatable foods high in fat and sugar that stimulate dopamine. Activation of κ-opioid receptors (KORs) reduces synaptic dopamine, but contribution of KORs to lower dopamine tone after dietary changes is unknown. Therefore, the purpose of this study was to determine the function of KORs in C57BL/6 mice that consumed a 60% high-fat diet (HFD) for six weeks followed by replacement of HFD with a control 10% fat diet for one day or one week. HFD replacement induced voluntary caloric restriction and weight loss. However, fast-scan cyclic voltammetry revealed no differences in baseline dopamine parameters, whereas sex effects were revealed during KOR stimulation. NAc core dopamine release was reduced by KOR agonism after one day of HFD replacement in females but after one week of HFD replacement in males. Further, elevated plus-maze testing revealed no diet effects during HFD replacement on overt anxiety. These results suggest that KORs reduce NAc dopamine tone and increase food-related anxiety during dietary weight loss interventions that could subsequently promote palatable food cravings and inhibit weight loss.

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“…In rodents, the most common model of obesity is chronic exposure to high fat (HFD) or high fat/high sugar diets. As observed in people with obesity, prolonged HFD exposure weakens signaling in dopamine reward circuits in male rats (101)(102)(103). Mice consume more calories overall, and chronic exposure devalues subsequent intake of standard chow after a fast in both sexes independent of body weight gain (109).…”

Section: Effects Of Elevated Body Weight In Paradigms Involving Stress and Feedingmentioning

confidence: 95%

“…In humans and rodents, diet-induced obesity is associated with changes in systems regulating reward and motivation to eat (99)(100)(101)(102)(103).…”

Section: Effects Of Elevated Body Weight In Paradigms Involving Stress and Feedingmentioning

confidence: 99%

A Framework for Developing Translationally Relevant Animal Models of Stress-Induced Changes in Eating Behavior

François¹,

Fernández-Gayol²,

Zeltser³

2022

Biological Psychiatry

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show abstract

Chronic high-fat diet affects food-motivated behavior and hedonic systems in the nucleus accumbens of male rats

Cited by 35 publications

References 48 publications

Behavioral and Metabolic Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation in Obese Male Rats

Behavioral and Metabolic Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation in Obese Male Rats

Replacing a Palatable High-Fat Diet with a Low-Fat Alternative Heightens κ-Opioid Receptor Control over Nucleus Accumbens Dopamine

A Framework for Developing Translationally Relevant Animal Models of Stress-Induced Changes in Eating Behavior

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