Chronic Hiccups

Reichenbach, Zachary Wilmer; Piech, Gregory; Malik, Zubair

doi:10.1007/s11938-020-00273-3

Cited by 18 publications

(18 citation statements)

References 79 publications

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“…Most acute hiccups are transient, benign and self-limited. However, persistent and intractable hiccups may be considered a sign of underlying pathology and although the most common cause is gastroesophageal reflux disease (GERD), atypical causes as COVID-19 are now identified in rare reports in the literature 1 , 2 .…”

Section: Introductionmentioning

confidence: 99%

COVID-19 presenting as persistent hiccups: a case report

Sene¹,

Watashi

Bilitardo³

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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Hiccups are involuntary, spasmodic contractions of the diaphragm and intercostal muscles and can be classified as acute (< 48 h), persistent (48 h to a month) or intractable (> 1 month). A previously healthy 29-year-old man sought the Emergency Department with flu-like symptoms and a two-day history of persistent hiccups. His physical examination was otherwise unremarkable and vital signs were within normal limits. An unenhanced computed tomography scan of the chest showed small focal ground-glass opacities scattered throughout 25% of the lungs. A COVID-19 test was positive. Chlorpromazine was prescribed for the hiccups with improvement over 10 h. The patient was discharged home on the same day without hiccups and no other complications.

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Section: Introductionmentioning

confidence: 99%

COVID-19 presenting as persistent hiccups: a case report

Sene¹,

Watashi

Bilitardo³

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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“…Many studies have found that a variety of methods can treat persistent hiccup, such as behavioral modifications, physical maneuvers, pharmacologic and nonpharmacologic interventions. [21] The common pharmacologic interventions include amitriptyline, baclofen, metoclopramide, and valproic acid. [27] However, all drugs have certain adverse effects, and the US Food and Drug Administration only approves chlorpromazine to treat hiccups.…”

Section: Discussionmentioning

confidence: 99%

Fatal posterior circulation stroke with persistent hiccups, sinus arrest and post-hiccup syncope: A case report

et al. 2023

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Rationale: Diagnosis of posterior circulation stoke is difficult, and magnetic resonance imaging especially diffusion-weighted imaging is superior to computed tomography. Persistent hiccups, sinus arrest, and post-hiccup syncope are extremely rare symptoms of posterior circulation stroke. However, there is no effective treatment for persistent hiccup.Patient concern and diagnosis: We describe a case of a 58-year-old hypertensive woman diagnosed with acute posterior circulation stroke who presented with persistent hiccups, sinus arrest, and post-hiccup syncope. Diffusion-weighted imaging revealed a high-intensity signal involving the left middle cerebellar peduncle and several spotted areas in the right occipital lobe.Interventions: Permanent pacemaker was implanted and metoclopramide was used to treat persistent hiccups.Outcome: The patient developed aspiration pneumonia and morbid dysphoria, and eventually died.Lessons: Posterior circulation stroke can cause cardiovascular and respiratory dysfunction. Consequently, physicians should pay more attention to posterior circulation lesions in patients with arrhythmia and syncope. An effective method to treat persistent hiccups is urgently needed.

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“…First, intractable hiccups were the only sign that raised suspicion of a central nervous system lesion. According to the hiccup reflex arc, 9 the afferent impulse was carried by the vagus nerve, phrenic nerve, and sympathetic nerve and then processed by the upper spinal cord, medulla oblongata near the respiratory centers, the reticular formation, and the thalamus. Finally, the efferent impulse was carried by the phrenic nerve to the diaphragm.…”

Section: Discussionmentioning

confidence: 99%

An uncommon cause of vertigo: Neuromyelitis optica spectrum disorder

Lin

Yang

2021

Ear Nose Throat J

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Neuromyelitis optica spectrum disorder (NMOSD) is an uncommon antibody-mediated disease of the central nervous system. Its classic presentation includes long segments of spinal cord inflammation, optic neuritis with or without intractable vomiting, and hiccups. Here, we described a case of a 39-year-old woman with an atypical presentation of vertigo, which was finally diagnosed as NMOSD by a positive serum aquaporin-4 antibody.

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Chronic Hiccups

Cited by 18 publications

References 79 publications

COVID-19 presenting as persistent hiccups: a case report

COVID-19 presenting as persistent hiccups: a case report

Fatal posterior circulation stroke with persistent hiccups, sinus arrest and post-hiccup syncope: A case report

An uncommon cause of vertigo: Neuromyelitis optica spectrum disorder

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