Chronic hepatitis <scp>C</scp> virus infection and lymphoproliferative disorders: Mixed cryoglobulinemia syndrome, monoclonal gammopathy of undetermined significance, and <scp>B</scp>‐cell non‐<scp>H</scp>odgkin lymphoma

Caviglia, Gian Paolo; Sciacca, C; Abate, Maria Lorena; Olivero, Antonella; Rosso, Chiara; Touscoz, Giovanni Antonio; Ciancio, Alessia; Rizzetto, Mario; Smedile, Antonina

doi:10.1111/jgh.12837

Cited by 22 publications

(21 citation statements)

References 25 publications

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“…The chronic stimulation of B-lymphocytes by HCV is associated with distinct humoral immune disorders, ranging from mixed cryoglobulinemia to monoclonal gammapathies. Occasionally it may lead to transformation of B cells and lymphomas [5]. Moreover, immune dysfunction associated with chronic hepatitis C may result in autoimmune disorders and rheumatologic conditions, including sicca syndrome, polyarthritis, thyroiditis, etc.…”

Section: Introductionmentioning

confidence: 99%

Extrahepatic comorbidities associated with hepatitis C virus in HIV-infected patients

Soriano

Berenguer

2015

Current Opinion in HIV and AIDS

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Section: Introductionmentioning

confidence: 99%

Extrahepatic comorbidities associated with hepatitis C virus in HIV-infected patients

Soriano

Berenguer

2015

Current Opinion in HIV and AIDS

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“…The prevalence of monoclonal gammopathies without cryoglobulinemia among CHC varies between 2% and 11% [5,7,8] while in healthy population MGUS affects approximately 3% of individuals >70 years of age and about 1% of those >50 years old [9] . In our study, 4.2% of CHC patients had a diagnosis of MGUS and the mean age was 61 years old [10] . In fact, the frequency of MGUS in normal population appears to be lower and age-dependent, suggesting that HCV infection acts as significant risk factor for MGUS occurrence at an earlier age, and supporting the concept that a continuous antigenic stimulation may be the underlying cause of monoclonal gammopathy development [5] .…”

Section: Research Highlightmentioning

confidence: 60%

Chronic HCV infection and lymphoproliferative disorders: association or causal relationship?

Caviglia

Sciacca

Smedile

2015

Abdomen

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Chronic hepatitis C virus (HCV) infection has been associated with several extrahepatic manifestations. A causal relationship has been suggested for lymphoproliferative disorders (LPD) development in the setting of chronic HCV infection. The molecular mechanism of HCV-associated lymphomagenesis remains unclear, although several theories have been proposed. In a recent study, we evaluated mixed cryoglobulinemia syndrome, monoclonal gammopathy of uncertain significance (MGUS) and B-cell non-Hodgkin lymphoma (B-NHL) prevalence in a cohort of 1313 CHC infected patients and we evaluate the association of virological and clinical factors with the presence of LPD. A positive association was found between the presence of cirrhosis and MGUS (OR=2.8924, 95%CI 1.2693-6.5909; p=0.012) and between cirrhosis and B-NHL (OR=3.9407, 95%CI 1.7226-9.0153; p=0.001). Moreover, we reported that 66.7% of patients with indolent B-NHL responders to antiviral treatment obtained a complete onco-hematological remission, supporting both the use of a first-line antiviral treatment of HCV-related indolent lymphomas and the plausible causal relationship between HCV infection and lymphomagenesis.

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“…The pathogenesis of the association of HCV infection with B-NHL remains poorly defined and is likely to involve both host (e.g., cirrhosis) [9] and (as yet unknown) viral factors. Based on the evidence for a causal relationship between HCV infection and B-NHL, eradication of HCV infection through effective antiviral regimens could signal prevention of disease progression and remission of concurrent B-NHL [3,4].…”

Section: Discussionmentioning

confidence: 99%

Sofosbuvir-based therapy cures hepatitis C virus infection after prior treatment failures in a patient with concurrent lymphoma

Romagnoli¹,

Marrazzo²,

Ballestri

et al. 2015

Journal of Clinical Virology

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We report on the first well-tolerated and successful use of sofosbuvir-based therapy in a patient in whom chronic infection with hepatitis C had preceded the development of B-cell non-Hodgkin's lymphoma. The patient had previously failed numerous attempts to clear the hepatitis C virus with traditional antiviral schedules. We demonstrate that sofosbuvir-based therapy resulted in cure of hepatitis C in a patient who had relapsed during combination therapy with an NS5A inhibitor, an NS3 protease inhibitor and ribavirin, as well as treatment failures to multiple courses of interferon-based therapy. This report also suggests that eradication of hepatitis C virus may result in the short-term prevention of B-cell non-Hodgkin's lymphoma relapse. The findings from our case require further validation in future cohorts of patients.

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Chronic hepatitis C virus infection and lymphoproliferative disorders: Mixed cryoglobulinemia syndrome, monoclonal gammopathy of undetermined significance, and B‐cell non‐Hodgkin lymphoma

Abstract: Despite the pathogenetic mechanism of HCV-associated LPDs is still unclear, cirrhosis is an additional risk factor for the development of lymphoproliferative disorders in patients with chronic HCV infection.

Cited by 22 publications

References 25 publications

Extrahepatic comorbidities associated with hepatitis C virus in HIV-infected patients

Extrahepatic comorbidities associated with hepatitis C virus in HIV-infected patients

Chronic HCV infection and lymphoproliferative disorders: association or causal relationship?

Sofosbuvir-based therapy cures hepatitis C virus infection after prior treatment failures in a patient with concurrent lymphoma

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