Chronic Hepatitis: In Vivo Proton MR Spectroscopic Evaluation of the Liver and Correlation with Histopathologic Findings

Can preoperative diffusion-weighted MRI predict postoperative hepatic insufficiency after curative resection of HBV-related hepatocellular carcinoma? A pilot study

“…Accordingly, although DW-MRI is potentially useful when other noninvasive tools have failed to assess liver fibrosis in patients with hepatitis C virus infection (which makes mostly micronodular structures in the liver) [14], it seems that DW-MRI with our current setting of 3-T MRI system is not applicable to patients with CHB. However, because the intra-and interobserver reliability of DW-MRI were proved to be significantly high in this study and various techniques are under investigation to improve the image quality [36][37][38][39][40], the usefulness of DW-MRI can be investigated again in the future for patients with CHB, especially for obese patients in whom LSM is often inadequate.…”

Diffusion-weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C

“…For example, proton spectroscopy at 1.5 T identifies various metabolites (choline and aliphatic hydrocarbons among others) that may be altered in both steatosis and fibrosis. 27 Perfusion MRI can detect the early alterations in the vascular architecture of fibrosis and cirrhosis. 28,29 Recently, the synergistic effects of gadolinium chelate and superparamagnetic iron oxide contrast agents in MRI for the hyperintense reticulation detection of fibrosis have achieved an accuracy greater than 90% for the diagnosis of fibrosis.…”

Magnetic resonance imaging of hepatic fibrosis: Emerging clinical applications

“…45 For patients with varying degrees of involvement with chronic hepatitis, an increasing PME/PDE ratio was found to correlate with necroinflammatory and fibrosis scores on liver histology compared with healthy volunteers. [52][53][54][55] Although differences between means for each group were 31 P, labeled phosphorus; ISIS, image selected in vivo spectroscopy; TR, repetition time; NA, number of acquisitions; PBC, primary biliary cirrhosis; CSI, chemical shift imaging; PME, phosphomonoester; Pi, inorganic phosphate; Glx, glutamate; Glu, glucose; GPE, glycerophosphorylethanolamine; GPC, glycerylphosphorylcholine; PE, phosphoethanolamine; PC, phosphocholine; PDE, phosphodiester; ATP, adenosine triphosphate; P, inorganic phosphorus; n/a, not available; CTP, Child-Turcotte-Pugh; HA, hyaluronic acid; MRE, magnetic resonance elastography. statistically significant, there was some overlap between the patient groups.…”