Chronic hepatitis C with early complication of Grave's disease during the treatment of pegylated interferon .ALPHA.-2a.

Maede, Yukiko; Morishita, Keiichi; Iwamura, K; Takayama, Yukiko; Tsukada, Yuriko; Kishino, Maiko; Shimizu, Takeshi; Matsushima, Shouzou; Komatsu, Tatsuji; Kasagi, Youko

doi:10.2169/naika.94.2600

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2007

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“…Pegylated IFN-α has been recently approved for the treatment of CHC and has been associated with only a few cases of autoimmune thyroiditis [6] . We herein describe the simultaneous development of diabetic ketoacidosis and Hashitoxicosis in a patient treated with pegylated IFN-α for CHC.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous development of diabetic ketoacidosis and Hashitoxicosis in a patient treated with pegylated interferon-alpha for chronic hepatitis C

Soultati¹

2007

WJG

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Classical interferon-alpha has been shown to be correlated with the development of a variety of autoimmune disorders. A 38 year-old female patient developed simultaneously diabetic ketoacidosis and hyperthyroidism 5 mo following initiation of treatment with pegylated interferon-α and ribavirin for chronic hepatitis C. High titers of glutamic acid decarboxylase, antinuclear and thyroid (thyroid peroxidase and thyroglobulin) antibodies were detected. Antiviral treatment was withdrawn and the patient was treated with insulin for insulin-dependent diabetes mellitus and propranolol for hyperthyroidism. Twelve months after cessation of pegylated interferon-α therapy the patient was euthyroid without any medication but remained insulin-dependent.

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Section: Introductionmentioning

confidence: 99%

Simultaneous development of diabetic ketoacidosis and Hashitoxicosis in a patient treated with pegylated interferon-alpha for chronic hepatitis C

Soultati¹

2007

WJG

View full text Add to dashboard Cite

show abstract

Chronic hepatitis C with early complication of Grave's disease during the treatment of pegylated interferon .ALPHA.-2a.

Abstract: Chronic hepatitis C with early complication of Grave's disease during the treatment of pegylated interferon ƒ¿-2a.

Cited by 1 publication

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Simultaneous development of diabetic ketoacidosis and Hashitoxicosis in a patient treated with pegylated interferon-alpha for chronic hepatitis C

Simultaneous development of diabetic ketoacidosis and Hashitoxicosis in a patient treated with pegylated interferon-alpha for chronic hepatitis C

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