Chronic hepatitis C viral infection reduces NK cell frequency and suppresses cytokine secretion: Reversion by anti-viral treatment

Dessouki, Omar; Kamiya, Yasuyuki; Nagahama, Hiroyasu; Tanaka, Motohiko; Suzu, Shinya; Sasaki, Yutaka; Okada, Seiji

doi:10.1016/j.bbrc.2010.02.008

Cited by 66 publications

(96 citation statements)

References 24 publications

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“…However, no significant differences were found between their levels between spontaneously resolved individuals and chronic HCV patients. This observation was consistent with Morishima et al [13], Bonorino et al [14] and Dessouki [15]. This could be explained by Meier [16] who suggested that the deficit in interleukin 15 (IL-15) might be responsible for this change.…”

Section: Discussionsupporting

confidence: 91%

“…In our study we noticed an expansion in CD56 +bright CD16 − NK cells in chronic HCV patients compared to healthy controls and spontaneously resolved individuals. This result was consistent with Ferlazzo et al [21] and Dessouki et al [15] and Jost et al [22].…”

Section: Discussionsupporting

confidence: 91%

“…On the other hand, Dessouki [15] reported that spontaneous resolvers and healthy controls showed the same total NK cell frequency.…”

Section: Discussionmentioning

confidence: 98%

See 2 more Smart Citations

Natural Killer Cell Subsets Distribution in Spontaneously Resolved and Chronic Persistent Hepatitis C Virus Infection

Kady¹,

Mansour²,

Gobran³

et al. 2017

J Clin Cell Immunol

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Natural Killer Cell Subsets Distribution in Spontaneously Resolved and Chronic Persistent Hepatitis C Virus Infection

Kady¹,

Mansour²,

Gobran³

et al. 2017

J Clin Cell Immunol

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“…Several researchers report that the function of NK cells appears to be polarized during development of chronic HCV infection. Cytotoxicity of NK cell is up-regulated while IFN-γ production by NK cells is down-regulated [33,36,38]. This functional polarization of NK cells may contribute to persistence of HCV virus and increased liver damages [38].…”

Section: Nk Cells and Hcv Infectionmentioning

confidence: 99%

“…In chronic HCV infection, the distribution and phenotype of NK cell subsets are also changed [33,34]. The frequency of CD56 dim CD16 + subset is decreased and the proportion of CD56-CD16 + subset with defective function is elevated in chronic HCV infection [12,35,36]. Some controversies are existed in the expression of NCRs.…”

Section: Nk Cells and Hcv Infectionmentioning

confidence: 99%

Natural Killer Cells in HCV Infection

Lü¹,

Shen²

2017

J Clin Cell Immunol

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Natural killer (NK) cells play a vital role in controlling viral infection. This commentary will introduce the alteration of NK cells in different infected status involving frequencies, phenotypes and functions. Moreover, it highlights the function of antibody-dependent cell-mediated cytotoxicity (ADCC) in HCV and other virus infection, and concerns its role in vaccine development and immunotherapies.

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Rapid early innate control of hepatitis C virus during IFN‐α treatment compromises adaptive CD4⁺T‐cell immunity

Pembroke¹,

Rees²,

Gallagher³

et al. 2012

Eur J Immunol

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The ability to control HCV with IFN-α-based treatments provides an opportunity in humans to study how the rate of viral clearance in vivo impinges on the development of antiviral responses. Ex vivo (IFN-γ-producing) and cultured antiviral CD4+ T cells, serum cytokines, and viral loads were measured repeatedly in a cohort of chronically HCV-infected subjects (n = 33) receiving IFN-α. Rapid control of virus indicated by an increased calculated rate of virus clearance, occurred in those subjects demonstrating absent/minimal T-cell responses (p < 0.0006). Surprisingly, in subjects who demonstrated the most robust T-cell responses (and reduced serum IL-10), there was actually a reduced rate of early virus clearance. A subsequent analysis of NK-cell function in available subjects (n = 8) revealed an inverse correlation between pretreatment NK-cell expression of NKp46 and the potential to upregulate cytotoxic function on exposure to IFN-α (p < 0.004), as well as the subsequent measured rate of viral clearance (p = 0.045). Thus, the CD4+ T-cell response during IFN-α treatment appears to be shaped by the rate of innate virus suppression. These data suggest that individuals who respond most effectively to immune intervention may be most in need of subsequent vaccination to prevent reinfection.

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Chronic hepatitis C viral infection reduces NK cell frequency and suppresses cytokine secretion: Reversion by anti-viral treatment

Cited by 66 publications

References 24 publications

Natural Killer Cell Subsets Distribution in Spontaneously Resolved and Chronic Persistent Hepatitis C Virus Infection

Natural Killer Cell Subsets Distribution in Spontaneously Resolved and Chronic Persistent Hepatitis C Virus Infection

Natural Killer Cells in HCV Infection

Rapid early innate control of hepatitis C virus during IFN‐α treatment compromises adaptive CD4⁺T‐cell immunity

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Chronic hepatitis C viral infection reduces NK cell frequency and suppresses cytokine secretion: Reversion by anti-viral treatment

Cited by 66 publications

References 24 publications

Natural Killer Cell Subsets Distribution in Spontaneously Resolved and Chronic Persistent Hepatitis C Virus Infection

Natural Killer Cell Subsets Distribution in Spontaneously Resolved and Chronic Persistent Hepatitis C Virus Infection

Natural Killer Cells in HCV Infection

Rapid early innate control of hepatitis C virus during IFN‐α treatment compromises adaptive CD4+T‐cell immunity

Contact Info

Product

Resources

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Rapid early innate control of hepatitis C virus during IFN‐α treatment compromises adaptive CD4⁺T‐cell immunity