Chronic hepatitis B: role of anti-platelet therapy in inflammation control

Aiolfi, Roberto; Sitia, Giovanni

doi:10.1038/cmi.2014.124

Cited by 34 publications

(39 citation statements)

References 36 publications

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“…Platelets are also known to be involved in acute and chronic liver disease related to hepatitis B virus infection via upregulation of virusspecific CD8 + T cells and nonspecific inflammatory cells into the liver (17). Furthermore, platelets were implicated in the clearance of bacterial infections: thrombin-stimulated platelets facilitated clearance of streptococci in infective endocarditis (18).…”

Section: Platelets and Pathogensmentioning

confidence: 99%

Nouvelle Cuisine: Platelets Served with Inflammation

Kapur

Zufferey

Boilard

et al. 2015

The Journal of Immunology

176

191

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Platelets are small cellular fragments with the primary physiological role of maintaining hemostasis. In addition to this well-described classical function, it is becoming increasingly clear that platelets have an intimate connection with infection and inflammation. This stems from several platelet characteristics, including their ability to bind infectious agents and secrete many immunomodulatory cytokines and chemokines, as well as their expression of receptors for various immune effector and regulatory functions, such as TLRs, which allow them to sense pathogen-associated molecular patterns. Furthermore, platelets contain RNA that can be nascently translated under different environmental stresses, and they are able to release membrane microparticles that can transport inflammatory cargo to inflammatory cells. Interestingly, acute infections can also result in platelet breakdown and thrombocytopenia. This report highlights these relatively new aspects of platelets and, thus, their nonhemostatic nature in an inflammatory setting.

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Section: Platelets and Pathogensmentioning

confidence: 99%

Nouvelle Cuisine: Platelets Served with Inflammation

Kapur

Zufferey

Boilard

et al. 2015

The Journal of Immunology

176

191

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show abstract

“…Platelet activation inhibitors including aspirin and clopidogrel also reduce acute hepatic necroinflammation and intrahepatic antigen‐specific CTL accumulation during murine viral hepatitis . Strikingly, reducing intrahepatic CTL accumulation in mice by long‐term low‐dose aspirin therapy serves to ameliorate the consequences of chronic hepatitis including fibrosis and the development of hepatocellular cancer …”

Section: Disease‐specific Platelet Contributionmentioning

confidence: 99%

Platelets: No longer bystanders in liver disease

et al. 2016

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Growing lines of evidence recognize that platelets play a central role in liver homeostasis and pathobiology. Platelets have important roles at every stage during the continuum of liver injury and healing. These cells contribute to the initiation of liver inflammation by promoting leukocyte recruitment through sinusoidal endothelium. They can activate effector cells, thus amplifying liver damage, and by modifying the hepatic cellular and cytokine milieu drive both hepatoprotective and hepatotoxic processes. Conclusion: In this review we summarize how platelets drive such pleiotropic actions and attempt to reconcile the paradox of platelets being both deleterious and beneficial to liver function; with increasingly novel methods of manipulating platelet function at our disposal, we highlight avenues for future therapeutic intervention in liver disease. (Hepatology 2016;64:1774‐1784)

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“…Based on recent pre-clinical studies, the inhibition of platelet activation pathways may represent an alternative therapeutic tool to decrease chronic inflammation, liver fibrosis and even HCC [10,11]. In this context, it is worth to note that activated platelets release a wide range of mediators, including growth factors and pro-angiogenic cytokines.…”

Section: Thrombosis Research J O U R N a L H O M E P A G E : W W W mentioning

confidence: 99%