Chronic headache and pituitary tumors

Levy, Miles; Matharu, Manjit; Goadsby, Peter J.

doi:10.1007/s11916-008-0014-5

Cited by 34 publications

(23 citation statements)

References 32 publications

(30 reference statements)

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“…Bone invasion might therefore result in irritation of these pain-sensitive structures with subsequent predisposition to headache. Whether especially an invasion of the cavernous sinus as proposed in other studies (33) is correlated with headache would be of particular interest. As a great part of the imaging studies were non-digital axial CT or MRI, such an assessment was not possible with our raw data, which require additional prospective studies.…”

Section: Discussionmentioning

confidence: 85%

Headache in patients with a meningioma correlates with a bone-invasive growth pattern but not with cytokine expression

Schankin¹,

Krumbholz

Sostak³

et al. 2009

Cephalalgia

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We included 58 patients with meningioma in a prospective study to analyse the prevalence of and risk factors for different types of meningioma-associated headache. Twenty-three patients (40%) had meningioma-associated headache. Of these, the pain was migraine-like in five (22%) and tension-type headache (TTH)-like in 13 (57%). Sixteen of 21 (76%) experienced relief of pain intensity of at least 50% after 18-24 months. Univariate analysis revealed bone-invasive growth pattern (P = 0.007) as a risk factor for headache and intake of antiepileptic drugs (P = 0.04) or large surrounding oedema (P = 0.04) as possible protective parameters. For migraine-like headache, risk factors were a positive history of migraine (P = 0.009) and bone-invasive growth pattern (P = 0.046) and, for TTH-like headache, only bone-invasive growth pattern (P = 0.009). Binary logistic regression analysis added to assess predictability and interaction effects could not identify a single factor predicting the occurrence of headache in the presence of a meningioma (correct prediction in 74% by a model consisting of bone-invasive growth pattern, history of head surgery, intake of antiepileptic drugs, temporal tumour location and moderate and large surrounding oedema). Analysis of 38 tumour specimens could not confirm the hypothesis that the occurrence of headache correlates with the expression magnitude of signal substances known to be present in meningiomas [stroma cell-derived factor 1, interleukin (IL)-1β, IL-6, vascular endothelial growth factor A] or thought to be relevant to headache/pain pathophysiology [prostaglandin-endoperoxide synthase 2, calcitonin-related polypeptide alpha, nitric oxide synthase (NOS) 1, NOS2A, NOS3, transforming growth factor-alpha, tumour necrosis factor, tachykinin, vasoactive intestinal peptide]. The affection of bone integrity and the expression of molecules thought to be relevant to headache pathophysiology might be important for meningioma-associated headache in predisposed individuals.

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Section: Discussionmentioning

confidence: 85%

Headache in patients with a meningioma correlates with a bone-invasive growth pattern but not with cytokine expression

Schankin¹,

Krumbholz

Sostak³

et al. 2009

Cephalalgia

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“…5 More subtle symptoms including headache may manifest, presumably attributed to stretching of the diaphragma sellae and/or dura of the pituitary fossa proper. 10 Enlarging NFPA may cause compression of the normal pituitary gland, resulting in impaired pituitary function and eventually to panhypopituitarism.…”

Section: Discussionmentioning

confidence: 99%

A single centre’s experience of stereotactic radiosurgery and radiotherapy for non-functioning pituitary adenomas with the Linear Accelerator (Linac)

Wilson

De-loyde

et al. 2012

Journal of Clinical Neuroscience

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“…Pituitary tumors come to clinical attention due to endocrine dysfunction, distortion of local structures surrounding the pituitary fossa, or as an incidental finding during neuroimaging for headache. 23 Evidence indicates that David performed a right-sided craniotomy on Haskil. 24 Headaches and increasing visual impairment clearly suggest a pituitary ademoma with suprasellar extension or a tuberculum sellae meningioma pressing on the chiasma opticum.…”

Section: Pituitary Tumorsmentioning

confidence: 99%

First Report of Awake Craniotomy of a Famous Musician: Suprasellar Tumor Surgery of Pianist Clara Haskil in 1942

Gasenzer

Kanat

Neugebauer

2017

J Neurol Surg A Cent Eur Neurosurg

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Clara Haskil (January 7, 1895-December 7, 1960) was one of the most famous female pianists of the 20th century. In her life and work she set new standards in piano playing. However, her career was beset by poor health and the adversities of two world wars. In her lifetime Haskil had three major disorders: juvenile scoliosis requiring treatment in her adolescence, a tumor of the sellar region requiring surgery at age 47 years, and a traumatic brain injury causing her death at the age of 65. Her medical history illustrates the development of surgical methods and rehabilitation in medicine before and after World War II. At an early age, she spent a year in a nursing home for orthopedic diseases due to scoliosis. In 1942, when she was 47 years old, she displayed the first symptoms of a suprasellar brain tumor: headache and hemianopsia. The famous surgeon Marcel David performed surgery on her without general anesthesia while Haskil mentally played a Mozart piano concerto as a neuronal representation to control her memory and mental abilities. Only 3 months after that operation she played a Mozart piano concerto at a concert that began her career as a great interpreter of Mozart. Her neurologic rehabilitation was remarkable and highlighted new methods in the field. In 1960, she traveled to Brussels for a concert. In the train station she stumbled on the stairs and hit her head on one of the steps. Skull fracture and intracranial hematoma were diagnosed. Doctors tried to operate on her but she lost consciousness and died. Haskil created new styles in piano playing, and her medical history offers indications of new concepts in neurosurgery.

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Chronic headache and pituitary tumors

Cited by 34 publications

References 32 publications

Headache in patients with a meningioma correlates with a bone-invasive growth pattern but not with cytokine expression

Headache in patients with a meningioma correlates with a bone-invasive growth pattern but not with cytokine expression

A single centre’s experience of stereotactic radiosurgery and radiotherapy for non-functioning pituitary adenomas with the Linear Accelerator (Linac)

First Report of Awake Craniotomy of a Famous Musician: Suprasellar Tumor Surgery of Pianist Clara Haskil in 1942

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