Chronic hand eczema: A prospective analysis of the Swiss CARPE registry focusing on factors associated with clinical and quality of life improvement

Cazzaniga, Simone; Ballmer‐Weber, Barbara; Gräni, N.; Spring, Philipp; Bircher, Andreas J.; Anliker, Mark; Sonntag, Anne-Katharina; Piletta, Pierre; Huber, Caroline; Diepgen, Thomas L.; Apfelbacher, Christian; Naldi, Luigi; Borradori, Luca; Simon, Dagmar

doi:10.1111/cod.13041

Cited by 16 publications

(36 citation statements)

References 35 publications

(95 reference statements)

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“…Overall, vesicular hand eczema patients showed a moderately impaired HRQoL, with the highest impairment noted in the QOLHEQ subdomain “symptoms.” We demonstrated that more severe hand eczema was associated with more impairment in HRQoL. The association between severity and HRQoL is in line with previous studies that used the Dermatology Life Quality Index to assess HRQoL and included all types of hand eczema . Female sex was associated with more impairment in HRQoL.…”

Section: Discussionsupporting

confidence: 90%

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Quality of life, treatment satisfaction, and adherence to treatment in patients with vesicular hand eczema: A cross‐sectional study

et al. 2020

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Background Recurrent vesicular hand eczema frequently has a chronic course and needs long‐term treatment. Objectives To evaluate health‐related quality of life (HRQoL), treatment satisfaction, and adherence in patients with vesicular hand eczema. Methods Patients using one main treatment for at least three months were included. Data on HRQoL (Quality of Life in Hand Eczema Questionnaire [QOLHEQ]), treatment satisfaction (Treatment Satisfaction Questionnaire for Medication, version II), and treatment adherence (4‐item Morisky Medication Adherence Scale) were collected. Univariate and multivariate regression analysis were used to predict variables associated with HRQoL. Results HRQoL was moderately impaired, with the highest impact in the QOLHEQ subdomain symptoms. Female sex, more severe hand eczema, and lower treatment satisfaction were associated with more impairment in HRQoL. Patients with severe/very severe hand eczema had significant lower “global satisfaction” scores compared with the other severity groups. The “global satisfaction” and treatment adherence in patients using systemic treatment were significantly higher compared with those with only topical treatment. Conclusions In patients with vesicular hand eczema disease severity affects both HRQoL and treatment satisfaction. Systemic treatment of severe hand eczema could improve the severity and as a result also HRQoL, treatment satisfaction, and medication adherence.

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Section: Discussionsupporting

confidence: 90%

“…The association between severity and HRQoL is in line with previous studies that used the Dermatology Life Quality Index to assess HRQoL and included all types of hand eczema. 6,18 Female sex was associated with more impairment in HRQoL. Female sex is a well-known demographic factor affecting HRQoL.…”

Section: Discussionmentioning

confidence: 99%

Quality of life, treatment satisfaction, and adherence to treatment in patients with vesicular hand eczema: A cross‐sectional study

et al. 2020

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“…The gender impact on development of hand eczema is still under discussion. There are studies which indicate to a higher risk for women, but others did not . In this study, women showed significant lower HEROS values, representing a better skin condition, probably due to a more frequent use of skin care products.…”

Section: Discussioncontrasting

confidence: 48%

“…There are studies which indicate to a higher risk for women, but others did not. 33 In this study, women showed significant lower HEROS values, representing a better skin condition, probably due to a more frequent use of skin care products. Change of skin perfusion with increasing age is discussed controversially.…”

Section: Discussionmentioning

confidence: 49%

The tissue viability imaging system—Suitable method for discovering minimal skin changes in occupational screenings? Results of a cross‐sectional field study

Weistenhöfer

Uter

Bernet

et al. 2019

Skin Research and Technology

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Background For early detection of initial skin changes in occupational screenings, only few objective assessment systems are available. Objectives With the aim of assessing an objective measurement method for hand eczema, we trialed the application of the tissue viability imaging (TiVi) system, quantifying erythema non‐invasively by polarized light spectroscopy. Materials and Methods In a field study with 625 employees of a semiconductor production company, 411 were exposed to prolonged wearing of occlusive gloves in the clean room. TiVi system and Hand Eczema Score for Occupational Screenings (HEROS), a quantitative skin score for the hands, were used, supplemented by a standardized personal interview. Results TiVi values of 65 up to 246 for each hand (palm or back), for each participant summed to overall 289 up to 848 (median 389), were measured. Higher TiVi values were noted for men, smokers, and with increasing age. Correlation between TiVi and HEROS was only weak. Several factors like skin pigmentation, thickness of the skin, or tattoos seem to influence TiVi results. Conclusions The practical relevance of one‐time measurements with the TiVi system in occupational screenings seems to be limited. Specifically, the TiVi system cannot replace dermatological examinations at the workplace. Notwithstanding, the application for other scientific purposes might be useful.

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“…Register studies that allow the analysis of treatments under reallife conditions may identify shortcomings and help to optimize health services. Currently, data on only one register on patients with chronic hand eczema are available (CARPE 80 and a Swiss "sister-registry" 81 ). Patients are prospectively assessed by dermatological examination and patient questionnaire, and socio-economic data and data on diagnostics, skin status, severity and treatment of chronic hand eczema and atopy criteria are repeatedly evaluated.…”

Section: Real-life Management Of Patients With Chronic and Severe Hanmentioning

confidence: 99%

Hand eczema: treatment

Elsner

Agner

2019

Acad Dermatol Venereol

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Hand eczema is a highly prevalent, multietiological disease with a wide spectrum of severity and chronicity. The treatment of hand eczema, especially in severe and chronic cases, is a challenge to the dermatologist requiring not only diagnostic and therapeutic, but also excellent patient communication skills. This review discusses the spectrum of therapeutic options for hand eczema, the evidence for their efficacy and safety, and proposes a stepwise approach of intensity of treatment depending on disease severity and chronicity. In the near future, hand eczema patients may benefit from new therapeutic principles such as biologics for the treatment of atopic eczema and topical Janus Kinase inhibitors.

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Chronic hand eczema: A prospective analysis of the Swiss CARPE registry focusing on factors associated with clinical and quality of life improvement

Abstract: Analysis of prospective data from CARPE-CH shows a complex pattern of associations among variables as shown by semantic map and classic statistical analyses. Factors related to occupational exposure had the highest impact on CHE.

Cited by 16 publications

References 35 publications

Quality of life, treatment satisfaction, and adherence to treatment in patients with vesicular hand eczema: A cross‐sectional study

Quality of life, treatment satisfaction, and adherence to treatment in patients with vesicular hand eczema: A cross‐sectional study

The tissue viability imaging system—Suitable method for discovering minimal skin changes in occupational screenings? Results of a cross‐sectional field study

Hand eczema: treatment

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