Chronic haemolysis following insertion of ball valve prostheses.

Yacoub, Magdi H.; Keeling, D. H.

doi:10.1136/hrt.30.5.676

Cited by 43 publications

(15 citation statements)

References 16 publications

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“…[1][2][3][4] In this study, we found a significant increase in erythrocyte creatine which was associated with slightly but significantly lower erythrocyte count, hemoglobin, and hematocrit levels in patients with aortic stenosis as compared with control subjects. These data indicate that bone marrow reserve failed to match erythrocyte output in the presence of intravascular hemolysis due to abnormal erythrocyte destruction in patients with aortic stenosis.…”

Section: Discussionmentioning

confidence: 63%

“…2,6,7,10) On the other hand, several markers including increased reticulocyte count, schistocyte count, and serum lactate dehydrogenase, or reduced haptoglobin have been applied to estimate the severity of intravascular hemolysis. 1,2,6,7,[18][19][20][21][22][23][24] Among these markers, serum lactate dehydrogenase has been widely used to estimate the severity of intravascular hemolysis in patients with cardiac valve prostheses, because a close relation between serum lactate dehydrogenase and half-life of 51 Crlabeled erythrocytes was demonstrated in patients with cardiac valve prostheses.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] Erythrocyte survival with a 51 Cr-labeling method has been utilized to estimate the severity of intravascular hemolysis in patients with prosthetic valves and valvular heart disease, and shortened erythrocyte survival was demonstrated in these patients. 2,6,7) However, the 51 Cr-labeling method requires exclusive equipment for radioactive materials and a prolonged examination period with a series of blood withdrawals from the patient. In contrast, erythrocyte creatine is regarded as a sensitive and quantitative marker of mean age of the erythrocytes, because creatine contents in erythrocytes decrease gradually with advancing cell age and an increase in erythrocyte creatine quantitatively reflects the degree of shortened erythrocyte survival.…”

Section: Ntravascular Hemolysis Has Been Identified In Patients Withmentioning

confidence: 99%

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Evaluation of Intravascular Hemolysis With Erythrocyte Creatine in Patients With Aortic Stenosis

et al. 2016

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SummaryChronic intravascular hemolysis has been identified in patients with cardiac valve prostheses, but only a few case reports have evaluated intravascular hemolysis in patients with native valvular heart disease. To detect intravascular hemolysis in patients with aortic stenosis, erythrocyte creatine was evaluated with hemodynamic indices obtained by echocardiography.Erythrocyte creatine, a marker of erythrocyte age, was assayed in 30 patients with aortic stenosis and 10 aged matched healthy volunteers. Peak flow velocity of the aortic valve was determined by continuous-wave Doppler echocardiography. Twenty of 30 patients with aortic stenosis had high erythrocyte creatine levels (> 1.8 µmol/g Hb) and erythrocyte creatine was significantly higher as compared with control subjects (1.98 ± 0.49 versus 1.52 ± 0.19 µmol/g Hb, P = 0.007). Peak transvalvular pressure gradient ranged from 46 to 142 mmHg and peak flow velocity ranged from 3.40 to 5.95 m/second. Patients with aortic stenosis had a significantly lower erythrocyte count (387 ± 40 versus 436 ± 42 × 10 4 µL, P = 0.002) and hemoglobin (119 ± 11 versus 135 ± 11 g/L, P < 0.001) as compared with control subjects. Erythrocyte creatine had a fair correlation with peak flow velocity (r = 0.55, P = 0.002).In conclusion, intravascular hemolysis due to destruction of erythrocytes was detected in patients with moderate to severe aortic stenosis and the severity of intravascular hemolysis was related to valvular flow velocity of the aortic valve. (Int Heart J 2016; 57: 430-433)

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Ntravascular Hemolysis Has Been Identified In Patients Withmentioning

confidence: 99%

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Evaluation of Intravascular Hemolysis With Erythrocyte Creatine in Patients With Aortic Stenosis

et al. 2016

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“…Previous studies (Andersen et al, 1965;Yacoub and Keeling, 1968) have shown that aortic ball valves will produce a chronic intravascular haemolysis even if functioning normally, but this is not severe and usually does not produce a significant anaemia. It does, 'however, increase the rate of clearance of the haptoglobin/haemoglobin complex from the serum and leads to deposition of haemosideri'n in the liver and kidneys.…”

Section: Resultsmentioning

confidence: 97%

“…haemolysis depends on the type of prosthetic valve and its competence (Schade et al, 1967;Yacoub and Keeling, 1968). Homograft aortic valves have established themselves as alternatives to mechanical prostheses (Ross, 1962;Barrett-Boyes, Lowe, Cole, and Kelly, 1965;Hocksema, Titus, Giuliani, and Kirklin, 1966;Ross and Yacoub, 1969).…”

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confidence: 99%

Red cell survival after homograft replacement of the aortic valve

Yacoub¹,

Kothari²,

Keeling³

et al. 1969

Thorax

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Red cell survival was studied in 21 patients following homograft replacement of the aortic valve. Autologous cells labelled with t1Cr were used. The T+ TtCr varied between 24 and 34 days, with only one patient below the normal limit of normal variations. The absence of haemolysis was confirmed by other haematological studies, including estimation of reticulocytes, serum lactic dehydrogenase, and urinary haemosiderin. Haptoglobin levels were low in most of the patients studied. In contrast to prosthetic valves there was no haemolysis in patients with regurgitation around or through the homograft valve. Intravascular haemolysis has been described after aortic valve replacement using a mechanical prosthesis. This applies to ball valves (Marsh, 1964;

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Replacement of Cardiac Valves in Children

Stanton¹

1970

Arch Pediatr Adolesc Med

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Chronic haemolysis following insertion of ball valve prostheses.

Cited by 43 publications

References 16 publications

Evaluation of Intravascular Hemolysis With Erythrocyte Creatine in Patients With Aortic Stenosis

Evaluation of Intravascular Hemolysis With Erythrocyte Creatine in Patients With Aortic Stenosis

Red cell survival after homograft replacement of the aortic valve

Replacement of Cardiac Valves in Children

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