Chronic granulomatous disease of childhood: Gastric manifestation and response to salazosulfapyridine therapy

Abstract

The case history of a 10-year-old boy with chronic granulomatous disease (CGD) and gastric obstruction is presented. First abdominal symptoms occurred at 4 years of age when antral narrowing was detected. Due to unresponsiveness to antibiotic and steroid treatment, salazosulfapyridine therapy was initiated. Objective remission was observed within 3 months and salazosulfapyridine was withdrawn after a further 6 months of therapy. At 6 years of age clinical and radiological recurrence of gastric obstruction was observed. Salazosulfapyridine was reinstated and continued as maintenance therapy. The child has been well for more than 4 years. Salazosulfapyridine therapy can be recommended as safe conservative treatment of gastric obstruction in CGD.

Chronic granulomatous disease with gastric antral narrowing: a study and follow-up by MRI

“…Narrowing of the gastric antrum is a rare but distinctive manifestation of chronic septic granulomatosis, as reported in the literature [4,5,6,7,8,9,10,11].…”

Corticosteroid therapy reversed progressive chronic granulomatous lung disease following deterioration on interferon‐γ treatment

“…Salazosulfapyridine has been successfully used in the management of gastric lesions in CGD patients. 7 TMP-SMZ was recently reported to have anti-in¯ammatory activity, which is probably the reason for its success in the treatment of Wegener's granulomatosis. 8 This property, together with its antimicrobial activity, could explain its unique, well-recognized bene®ts on the longterm survival of CGD patients.…”

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