Chronic Granulomatous Disease Carrier With Recurrent Poor Obstetric Outcome

Abstract

Carriers of chronic granulomatous disease should be monitored closely during pregnancy, as if they have the disease. To decrease the risk of infectious morbidity and mortality, obstetricians should have a low threshold for starting prophylactic antibiotics early during pregnancy, even if the patient is asymptomatic.

Treatment of Chronic Granulomatous Disease–Related Pulmonary Aspergillus Infection in Late Pregnancy

“…There are few published data on pregnancy in patients with CGD. A case report described an X-linked carrier of CGD who had serial episodes of chorioamnionitis resulting in early delivery in 3 pregnancies, 1 of which resulted in neonatal death due to sepsis [ 5 ]. Another report documented an uncomplicated pregnancy of a woman with CGD, but the patient developed Aspergillus fumigatus lumbosacral osteomyelitis in the early postpartum period [ 6 ].…”

“…Another report documented an uncomplicated pregnancy of a woman with CGD, but the patient developed Aspergillus fumigatus lumbosacral osteomyelitis in the early postpartum period [ 6 ]. At least 2 older case reports have described uneventful pregnancies in patients with CGD [ 5 ]. Hisano et al described successful completion of pregnancy with term delivery in a woman with CGD who had been carefully monitored and treated with TMP/SMX 160/800 mg daily (with augmented folate supplementation) during conception and throughout pregnancy [ 7 ].…”