Chronic glucocorticoid treatment induced circadian clock disorder leads to lipid metabolism and gut microbiota alterations in rats

Wu, Tao; Yang, Luna; Jiang, Jianguo; Ota, Tsuguhito; Zhu, Jiawei; Zheng, Xiaojun; Wang, Qi; Lu, Xin; Fu, Zhengwei

doi:10.1016/j.lfs.2017.11.049

Cited by 95 publications

(72 citation statements)

References 51 publications

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“…Our results demonstrate how an increase in cortisol can affect the diversity and structure of the salmon gut microbiome, which may in turn contribute to the adverse effects of stress on fish health. This is consistent with the results of previous studies that experimentally administered glucocorticoids to rats, mice and pigs (Huang et al 2015; Petrosus et al 2018; Wu et al 2018). However, it is not clear exactly how cortisol may affect different taxa within complex host-associated microbial communities.…”

Section: Discussionsupporting

confidence: 93%

“…These genera include a range of opportunistic fish pathogens (Austin & Austin 2007), and tend to increase following exposure to different types of environmental stress in fish (Boutin et al 2013; Uren Webster et al 2019), suggesting they may represent a common signature of stress exposure. In mammals, experimental administration of cortisol results in a similar reduction in probiotic lactic acid-producing bacteria and an increase in pro-inflammatory microbiota (Huang et al 2015; Petrosus et al 2018; Wu et al 2018), suggesting that these bacteria taxa could represent useful biomarkers of stress across vertebrates.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated plasma cortisol, resulting from social or psychological stress, has been associated with alterations in the structure and/or diversity of the mammalian faecal or oral microbiome, including the abundance of lactic acid bacteria and opportunistic pathogens (Galley et al 2014; Jasarevic et al 2015; Mudd et al 2017). Direct administration of glucocorticoids has also been shown to exert stimulatory and inhibitory effects on specific microbial taxa, together with wider effects on host metabolism in some cases (Huang et al 2015; Jentsch et al 2013; Petrosus et al 2018; Wu et al 2018). Additionally, while host stress response influences the microbiome, the microbiome can also influence host stress response.…”

Section: Introductionmentioning

confidence: 99%

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Cortisol-induced signatures of stress in the fish microbiome

Webster

Rodríguez‐Barreto

Consuegra

et al. 2019

Preprint

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Stress experienced in intensive aquaculture can compromise fish growth, condition and immunity. Microbiome disruption may contribute to these adverse health effects, but little is known about how stress affects fish microbial communities. Here, we specifically examined the effects of stress-induced cortisol production on the fish microbiome. We exposed juvenile Atlantic salmon to a mild confinement stressor for two weeks. We then measured cortisol in the plasma, skin-mucus and faeces, and characterised the skin and faecal microbiome. Faecal and skin cortisol concentrations increased in fish exposed to confinement stress, and were positively correlated with plasma cortisol. Elevated faecal cortisol was associated with pronounced changes in the diversity and structure of the faecal microbiome. In particular, we identified a marked decline in probiotic Lactobacillales (Carnobacterium sp.) and an increase in pro-inflammatory and pathogenic taxa within the classes Clostridia and Gammaproteobacteria. In contrast, skin-mucus cortisol concentrations were lower and not associated with any detectable changes in the skin microbiome. Our results demonstrate that cortisol disrupts the gut microbiome, which may, in turn, contribute to the adverse effects of stress on fish health. They also highlight the value of using non-invasive faecal samples to monitor stress, including simultaneous determination of cortisol and stress-responsive bacteria.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cortisol-induced signatures of stress in the fish microbiome

Webster

Rodríguez‐Barreto

Consuegra

et al. 2019

Preprint

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“…Similar to the observations in mouse gut microbiota, an altered feeding schedule in humans impacts the diurnal fluctuation in microbiota abundance . Nevertheless, in both species circadian clock regulated endocrine factors like melatonin or corticosteroids could also play a role.…”

Section: Diurnal Oscillations In Microbiotasupporting

confidence: 64%

At the Intersection of Microbiota and Circadian Clock: Are Sexual Dimorphism and Growth Hormones the Missing Link to Pathology?

2019

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Reciprocal interactions between the host circadian clock and the microbiota are evidenced by recent literature. Interestingly, dysregulation of either the circadian clock or microbiota is associated with common human pathologies such as obesity, type 2 diabetes, or neurological disorders. However, it is unclear to what extent a perturbation of pathways regulated by both the circadian clock and microbiota is involved in the development of these disorders. It is speculated that these perturbations are associated with impaired growth hormone (GH) secretion and sexual development. The GH axis is a broadly neglected pathway and could be the main converging point for the interaction of both circadian clock and microbiota. Here, the links between the circadian clock and microbiota are reviewed. Finally, the effects of chronodisruption and dysbiosis on physiology and pathology are discussed and it is speculated whether a common deregulation of the GH pathway could mediates those effects.

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“…There is a complex role of the gut microbiota in the maintenance of bone health. As previously reported, GC treatment reduced the microbial richness and diversity, whereas it re‐increased after TBP treatments. However, CC treatment showed less impact on the gut microbiota, in terms of richness, diversity, and overall structure.…”

Section: Discussionmentioning

confidence: 99%

Tuna Bone Powder Alleviates Glucocorticoid‐Induced Osteoporosis via Coregulation of the NF‐κB and Wnt/β‐Catenin Signaling Pathways and Modulation of Gut Microbiota Composition and Metabolism

Yang

et al. 2020

Molecular Nutrition Food Res

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Scope The effects and mechanism of tuna bone powder (TBP) on glucocorticoid‐induced osteoporosis (GIOP) alleviation in terms of signaling pathway coregulation and gut microbiota modulation are investigated. Methods and results The powder size distribution and composition of TBP are measured. The GIOP female mice induced by dexamethasone intramuscular injection are used to examine the anti‐osteoporosis effects of TBP in a 10 week experiment, and improved bone mineral density and bone microarchitecture are observed via micro‐CT. In addition, qRT‐PCR results show that the NF‐κB pathway is inhibited to reduce bone resorption, whereas the Wnt/β‐catenin pathway is activated to enhance bone formation after treatment. Moreover, TBP treatments suppress the release of pro‐inflammatory cytokines, repair dysfunction of the intestinal epithelial barrier, and prevent aggravated systemic inflammation in mRNA levels. Additionally, 16S rRNA gene sequencing indicate that TBP treatments enhance the abundance of anti‐inflammatory bacteria and short‐chain fatty acid (SCFA) producers, which is consistent with increased SCFA contents in feces measured via GC–MS. Conclusion These data show that TBP ameliorates GIOP in mice through four aspects, including coregulating signaling pathways, blocking proinflammatory cytokines, repairing the intestinal epithelial barrier, and modulating gut microbiota. Therefore, TBP may be a potential prebiotic agent to alleviate osteoporosis in humans.

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Chronic glucocorticoid treatment induced circadian clock disorder leads to lipid metabolism and gut microbiota alterations in rats

Cited by 95 publications

References 51 publications

Cortisol-induced signatures of stress in the fish microbiome

Cortisol-induced signatures of stress in the fish microbiome

At the Intersection of Microbiota and Circadian Clock: Are Sexual Dimorphism and Growth Hormones the Missing Link to Pathology?

Tuna Bone Powder Alleviates Glucocorticoid‐Induced Osteoporosis via Coregulation of the NF‐κB and Wnt/β‐Catenin Signaling Pathways and Modulation of Gut Microbiota Composition and Metabolism

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