Chronic Glomerulonephritis Associated With Low Serum Complement Activity (Chronic Hypocomplementemic Glomerulonephritis)

Glomerular deposition of properdin in acute and chronic glomerulonephritis with hypocomplementemia

“…In other diseases, even with intense immunofluorescence for PiC and/or IgG, properdin was, as a rule, not found (Table II) found deposited in the glomeruli in AGN and HCGN (5,6,18). Although this phenomenon can be observed late in "one shot" serum sickness in rabbits (19), it is not seen acutely or in the chronic disease model.…”

“…The diagnosis of specific renal diseases was made on the basis of clinical history, physical findings, laboratory analysis, and renal histopathology as outlined in previous publications (5,6). Tissue obtained by kidney biopsy and nephrectomy over a 4 month period of time was studied by immunofluorescent and light microscopy.…”

Evidence for Complement Activation via the Alternate Pathway in Skin Diseases I HERPES GESTATIONIS, SYSTEMIC LUPUS ERYTHEMATOSUS, AND BULLOUS PEMPHIGOID

“…Fresh blister fluid from three of these bullous pemphigoid patients, stored at -700 until used, however, demonstrated on immunoelectrophoresis the presence of the a-migrating C3A as wvell as the P-migrating C3PA. Jordon (27,28). Patient F. L. with herpes gestationis had normal complement levels (CH50 and C3) before and during therapy.…”

Metabolic Studies of the Third Component of Complement and the Glycine-Rich Beta Glycoprotein in Patients with Hypocomplementemia

“…No studies of GBG metabolism in health or disease have yet been reported but previous studies of C3 metabolism in patients with hypocomplementemic MCGN have given variable results. Some workers (13,3) have found reducd C3 synthesis, while others (14,15) have found accelerated C3 catabolism to be the major immediate cause of hypocomplementemia. METHODS…”