Chronic Gastrointestinal and Joint-Related Sequelae Associated with Common Foodborne Illnesses: A Scoping Review

Pogreba-Brown, Kristen; Austhof, Erika; Armstrong, A S; Schaefer, K.; Villa‐Zapata, Lorenzo; McClelland, Deborah Jean; Batz, Michael; Kuecken, Maria; Riddle, Mark S.; Porter, Chad K.; Bazaco, Michael C.

doi:10.1089/fpd.2019.2692

Cited by 28 publications

(14 citation statements)

References 167 publications

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“…In 2020, the reported EU-wide incidence of campylobacteriosis was 40.3 cases per 100 000 population, with one of the highest rates of 116.4 recorded in Luxembourg [1]. Beyond gastroenteritis, Campylobacter infection may occasionally trigger the development of sequelae, such as reactive arthritis, Guillain-Barré syndrome and irritable bowel syndrome [2]. In human cases, Campylobacter jejuni is predominant (83.1 %), followed by Campylobacter coli (10.8%) [3].…”

Section: Introductionmentioning

confidence: 99%

Environmental dynamics of Campylobacter jejuni genotypes circulating in Luxembourg: what is the role of wild birds?

et al. 2023

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Campylobacter jejuni is the leading cause of bacterial gastroenteritis worldwide, but, unlike other foodborne pathogens, is not commonly reported as causing outbreaks. The population structure of the species is characterized by a high degree of genetic diversity, but the presence of stable clonally derived genotypes persisting in space and time, and potentially leading to diffuse outbreaks, has recently been identified. The spread of these recurring genotypes could be enhanced by wild birds, suspected to act as vectors for a wide range of microorganisms that can be transmissible to other animals or humans. This study assessed the genetic diversity of C. jejuni carriage in wild birds and surface waters to explore a potential link between these environments and the persistence over years of recurring lineages infecting humans in Luxembourg. These lineages corresponded to over 40 % of clinical isolates over a 4 year period from 2018 to 2021. While mainly exotic genotypes were recovered from environmental samples, 4 % of C. jejuni from wild birds corresponded to human recurring genotypes. Among them, a human clinical endemic lineage, occurring for over a decade in Luxembourg, was detected in one bird species, suggesting a possible contribution to the persistence of this clone and its multi-host feature. Whereas 27 % of wild birds were carriers of C. jejuni, confirming their role as spreader or reservoir, only three out of 59 genotypes overlapped with recurring human strains. While direct transmission of C. jejuni infection through wild birds remains questionable, they may play a key role in the environmental spreading of stable clones to livestock, and this issue merits further investigation.

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Section: Introductionmentioning

confidence: 99%

Environmental dynamics of Campylobacter jejuni genotypes circulating in Luxembourg: what is the role of wild birds?

et al. 2023

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“…[1] Post-infectious IBS (PI-IBS), has been linked to acute bacterial, protozoal and viral infections. [2] However, little is known about PI-IBS following acute COVID-19 infection. Infection with SARS-CoV-2 includes a wide range of symptoms including fever, cough, shortness of breath, fatigue, and in some cases gastrointestinal symptoms.…”

Section: Introductionmentioning

confidence: 99%

“…Prevalence within the U.S. has been estimated to be 10–15% within adults [ 1 ]. Post-infectious IBS (PI-IBS), has been linked to acute bacterial, protozoal and viral infections [ 2 ]. However, little is known about PI-IBS following acute coronavirus disease 2019 (COVID-19) infection.…”

Section: Introductionmentioning

confidence: 99%

Persisting gastrointestinal symptoms and post-infectious irritable bowel syndrome following SARS-CoV-2 infection: results from the Arizona CoVHORT

et al. 2022

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In this study, we aimed to examine the association between gastrointestinal (GI) symptom presence during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the prevalence of GI symptoms and the development of post-infectious irritable bowel syndrome (PI-IBS). We used data from a prospective cohort and logistic regression to examine the association between GI symptom status during confirmed SARS-CoV-2 infection and prevalence of persistent GI symptoms at ≥45 days. We also report the incidence of PI-IBS following SARS-CoV-2 infection. Of the 1475 participants in this study, 33.8% (n = 499) had GI symptoms during acute infection. Cases with acute GI symptoms had an odds of persisting GI symptoms 4 times higher than cases without acute GI symptoms (odds ratio (OR) 4.29, 95% confidence interval (CI) 2.45–7.53); symptoms lasted on average 8 months following infection. Of those with persisting GI symptoms, 67% sought care for their symptoms and incident PI-IBS occurred in 3.0% (n = 15) of participants. Those with acute GI symptoms after SARS-CoV-2 infection are likely to have similar persistent symptoms 45 days and greater. These data indicate that attention to a potential increase in related healthcare needs is warranted.

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“…However, severe courses of disease can lead to hospitalizations and different long-term complications weeks or even years after an infection. Among reported post-infectious sequelae of CE are reactive arthritis (REA), Guillain-Barre ´syndrome (GBS), inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Health care utilizations and costs of Campylobacter enteritis in Germany: A claims data analysis

et al. 2023

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Objective The number of reported cases of Campylobacter enteritis (CE) remains on a high level in many parts of the world. The aim of this study was to analyze the health care utilizations and direct and indirect costs of CE and sequelae of patients insured by a large health insurance with 26 million members in Germany. Methods Claims data of insurants with at least one CE diagnosis in 2017 (n = 13,150) were provided, of which 9,945 were included in the analysis of health care utilizations and costs. If medical services were not diagnosis-linked, CE-associated costs were estimated in comparison to up to three healthy controls per CE patient. Indirect costs were calculated by multiplying the work incapacities by the average labor costs. Total costs of CE in Germany were extrapolated by including all officially reported CE cases in 2017 using Monte Carlo simulations. Results Insurants showed a lower rate of 56 CE diagnoses per 100,000 than German surveillance data for 2017, but with a similar age, gender and regional distribution. Of those CE cases, 6.3% developed post-infectious reactive arthritis, Guillain-Barré syndrome (GBS), inflammatory bowel disease (IBD) and/or irritable bowel syndrome (IBS). Health care utilizations differed depending on CE severity, age and gender. Average CE-specific costs per patient receiving outpatient care were € 524 (95% CI 495–560) over a 12-month period, whereas costs per hospitalized CE case amounted to € 2,830 (2,769–2,905). The analyzed partial costs of sequelae ranged between € 221 (IBS) and € 22,721 (GBS) per patient per 12 months. Total costs of CE and sequelae extrapolated to Germany 2017 ranged between € 74.25 and € 95.19 million, of which 10–30% were due to sequelae. Conclusion CE is associated with a substantial economic burden in Germany, also due to care-intensive long-lasting sequelae. However, uncertainties remain as to the causal relationship of IBD and IBS after CE.

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Chronic Gastrointestinal and Joint-Related Sequelae Associated with Common Foodborne Illnesses: A Scoping Review

Cited by 28 publications

References 167 publications

Environmental dynamics of Campylobacter jejuni genotypes circulating in Luxembourg: what is the role of wild birds?

Environmental dynamics of Campylobacter jejuni genotypes circulating in Luxembourg: what is the role of wild birds?

Persisting gastrointestinal symptoms and post-infectious irritable bowel syndrome following SARS-CoV-2 infection: results from the Arizona CoVHORT

Health care utilizations and costs of Campylobacter enteritis in Germany: A claims data analysis

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